Polyneuropathy caused by chlorprothixene.

Abstract:

:Seven chronic psychiatric patients developed signs of polyneuropathy mainly in the lower limbs after receiving chlorprothixene (500-1800 mg/d) from 3 to more than 24 months. The most prominent electroneuromyographic findings were decreased or not measurable motor conduction velocities of the peroneal nerves. Electromyography showed signs of denervation in the leg muscles in all the patients, and also in the upper limbs in 4 of them. The signs of polyneuropathy gradually subsided after withdrawal of chlorprothixene. Thus, chlorprothixene may cause a toxic, dose-dependent, reversible polyneuropathy.

journal_name

Acta Psychiatr Scand

authors

Luisto M

doi

10.1111/j.1600-0447.1992.tb08604.x

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

246-8

issue

3

eissn

0001-690X

issn

1600-0447

journal_volume

85

pub_type

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