A double-blind comparison of raclopride and haloperidol in the acute phase of schizophrenia. The British Isles Raclopride Study Group.

Abstract:

:This is the first comparative double-blind study of raclopride. Ninety-one patients with acute schizophrenia received either raclopride 2-8 mg twice daily or haloperidol 5-20 mg twice daily for 4 weeks. Both neuroleptics produced clinical improvements. There were no significant between-drug differences in overall efficacy measurements as assessed by the schizophrenia change sub-scale of the Comprehensive Psychopathological Rating Scale and the Krawiecka (Manchester) Rating Scale. Assessment by the Clinical Global Impression scale found haloperidol to be more effective. There were significantly fewer extrapyramidal symptoms with raclopride and a significantly lower incidence of acute dystonia. The results suggest that raclopride has an antipsychotic effect with a low incidence of extrapyramidal side effects.

journal_name

Acta Psychiatr Scand

authors

doi

10.1111/j.1600-0447.1992.tb03286.x

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

391-8

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

86

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章,随机对照试验

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