Prospective investigations of the prodromal state of schizophrenia: review of studies.

Abstract:

OBJECTIVE:The paper presents a comprehensive overview of prospective studies monitoring or intervening in the pre-onset phase of first episode psychosis. METHOD:A systematic literature search was conducted and supplemented by a manual search. All relevant studies were ordered and intensively reviewed according to specified criteria. Methodological and conceptual issues are discussed. RESULTS:Reports of 23 prospective studies were found, some describing subsamples of larger samples. Major methodological and conceptual divergences exist. CONCLUSION:Applied criteria detect individuals with a significantly increased risk of psychosis within the schizophrenia spectrum, but these criteria are only validated on clinical populations. The significance of differences in sample-characteristics is unclear. Most study samples are small. Results are preliminary and in need of further research before they constitute a realistic knowledge base. Methodological and conceptual issues should not be underestimated.

journal_name

Acta Psychiatr Scand

authors

Olsen KA,Rosenbaum B

doi

10.1111/j.1600-0447.2005.00697.x

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

247-72

issue

4

eissn

0001-690X

issn

1600-0447

pii

ACP697

journal_volume

113

pub_type

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