A double-blind study of alprazolam and oxazepam in the treatment of anxiety.

Abstract:

:In a randomized double-blind study with parallel group design involving 60 anxious psychoneurotic outpatients, the anxiolytic activity of alprazolam was compared with that of oxazepam. Following a 4 to 7-day placebo washout period, both groups showed a similar and significant response to treatment during the 4-week active treatment phase. An important intergroup difference emerged in the fear/anxiety component of the Lipman SRSS with the alprazolam groups showing a significantly greater mean reduction from the baseline score. During alprazolam treatment there was also a significant reduction in the depression factor score of the Lipman SRSS by the termination of the study and for all 4 weeks combined. Furthermore, the global impression of treatment was judged by patients as more favourable towards alprazolam than towards oxazepam. Only one person in each group reported a serious side effect. The results indicate that the anxiolytic activity of alprazolam is at least as good as that of oxazepam.

journal_name

Acta Psychiatr Scand

authors

Väisänen E,Jalkanen E

doi

10.1111/j.1600-0447.1987.tb02830.x

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

536-41

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

75

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2004-02-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    更新日期:1985-03-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb06330.x

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    更新日期:1988-08-01 00:00:00

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    更新日期:1983-02-01 00:00:00

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    pub_type: 杂志文章

    doi:

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    更新日期:1988-04-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: von Knorring L,Lindström E

    更新日期:1992-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06252.x

    authors: McNeil TF,Thelin T,Aspegren-Jansson E,Sveger T

    更新日期:1986-10-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0447.1998.tb10106.x

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb06410.x

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    更新日期:1988-12-01 00:00:00

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