A double blind comparison of lofepramine, imipramine and placebo in patients with depression.

Abstract:

:The results of double blind trial in which 139 patients with primary depression were randomly assigned to either lofepramine (46), imipramine (48), or placebo (45) are discussed. After treatment with either active drug, lofepramine or imipramine, the clinical outcome was significantly greater than with placebo. No significant differences were found in clinical responses between lofepramine and imipramine. With regard to reported side effects, however, a statistically significant lower number of severe and/or moderate side effects were reported for the lofepramine group than for the imipramine group. In particular, for severe and/or moderate occurrences of dry mouth, the statistically significant lower incidence in favor of lofepramine is by almost a factor of 3 (8 lofepramine vs 21 imipramine patients).

journal_name

Acta Psychiatr Scand

authors

Feighner JP,Meridith CH,Dutt JE,Hendrickson GG

doi

10.1111/j.1600-0447.1982.tb00918.x

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

100-8

issue

2

eissn

0001-690X

issn

1600-0447

journal_volume

66

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1111/j.1600-0447.1985.tb02591.x

    authors: Perris C,Maj M,Perris H,Eisemann M

    更新日期:1985-08-01 00:00:00

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    doi:10.1111/j.1600-0447.1991.tb05558.x

    authors: Keks NA,Copolov DL,Mackie B,Stuart GW,Singh BS,McGorry PD,Coffey C

    更新日期:1991-05-01 00:00:00

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    doi:10.1111/j.1600-0447.2008.01252.x

    authors: Braakman MH,Kortmann FA,van den Brink W

    更新日期:2009-01-01 00:00:00

  • Comorbidity of physical and mental disorders and the effect on work-loss days.

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    doi:10.1111/j.1600-0447.2005.00513.x

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  • Incidence of medically treated depression in Denmark among individuals 15-44 years old: a comprehensive overview based on population registers.

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    pub_type: 杂志文章

    doi:10.1111/acps.13028

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12835

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    更新日期:2018-01-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0447.1989.tb10262.x

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    更新日期:1989-04-01 00:00:00

  • Outcomes of involuntary hospital admission--a review.

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    pub_type: 杂志文章,评审

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  • Moroccan national study on prevalence of mental disorders: a community-based epidemiological study.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1600-0447.2008.01270.x

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb01426.x

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    更新日期:1991-07-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2009-05-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章

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  • Subjective and external assessments of quality of life in schizophrenia: relationship to insight.

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    pub_type: 杂志文章

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    更新日期:1999-06-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1991-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

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    更新日期:2010-06-01 00:00:00

  • Diagnosis of killers seen for psychiatric assessment. A controlled study.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1982.tb00930.x

    authors: Langevin R,Paitich D,Orchard B,Handy L,Russon A

    更新日期:1982-09-01 00:00:00

  • Service utilization and costs of first-onset schizophrenia in two widely differing health service areas in North-East Spain. PSICOST Group.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1999.tb10876.x

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05136.x

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    更新日期:1988-03-01 00:00:00

  • Beck's Depression Inventory as a screening instrument for adolescent depression in Sweden: gender differences.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1987.tb05628.x

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