Abstract:
OBJECTIVE:The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs). METHOD:Thirty UHR individuals and 23 HCs underwent MR diffusion tensor imaging before and after 12 months of non-manualized standard care. Positive and negative symptoms and level of functioning were assessed. Tract-based spatial statistics were employed. RESULTS:During 12 months, none of the UHR individuals transitioned to psychosis. Both UHR individuals and HCs increased significantly in fractional anisotropy (FA). UHR individuals showed significant FA increases predominantly in the left superior longitudinal fasciculus (SLF) (P = 0.01), and HCs showed significant FA increases in the left uncinate fasciculus (P = 0.03). Within UHR individuals, a significant positive correlation between FA change and age was observed predominantly in the left SLF (P = 0.02). Within HCs, no significant correlation between FA change and age was observed. No significant correlations between baseline FA and clinical outcomes were observed; however, FA changes were significantly positively correlated to changes in negative symptoms (P = 0.04). CONCLUSION:As normal brain maturation occurs in a posterior to frontal direction, our findings could suggest disturbed WM maturation in UHR individuals.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Krakauer K,Nordentoft M,Glenthøj BY,Raghava JM,Nordholm D,Randers L,Glenthøj LB,Ebdrup BH,Rostrup Edoi
10.1111/acps.12835subject
Has Abstractpub_date
2018-01-01 00:00:00pages
65-78issue
1eissn
0001-690Xissn
1600-0447journal_volume
137pub_type
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journal_title:Acta psychiatrica Scandinavica
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journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
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journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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