White matter maturation during 12 months in individuals at ultra-high-risk for psychosis.

Abstract:

OBJECTIVE:The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs). METHOD:Thirty UHR individuals and 23 HCs underwent MR diffusion tensor imaging before and after 12 months of non-manualized standard care. Positive and negative symptoms and level of functioning were assessed. Tract-based spatial statistics were employed. RESULTS:During 12 months, none of the UHR individuals transitioned to psychosis. Both UHR individuals and HCs increased significantly in fractional anisotropy (FA). UHR individuals showed significant FA increases predominantly in the left superior longitudinal fasciculus (SLF) (P = 0.01), and HCs showed significant FA increases in the left uncinate fasciculus (P = 0.03). Within UHR individuals, a significant positive correlation between FA change and age was observed predominantly in the left SLF (P = 0.02). Within HCs, no significant correlation between FA change and age was observed. No significant correlations between baseline FA and clinical outcomes were observed; however, FA changes were significantly positively correlated to changes in negative symptoms (P = 0.04). CONCLUSION:As normal brain maturation occurs in a posterior to frontal direction, our findings could suggest disturbed WM maturation in UHR individuals.

journal_name

Acta Psychiatr Scand

authors

Krakauer K,Nordentoft M,Glenthøj BY,Raghava JM,Nordholm D,Randers L,Glenthøj LB,Ebdrup BH,Rostrup E

doi

10.1111/acps.12835

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

65-78

issue

1

eissn

0001-690X

issn

1600-0447

journal_volume

137

pub_type

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