Abstract：
OBJECTIVE:Literature suggests that childhood trauma increases vulnerability for schizophrenia-spectrum disorders, including schizotypal personality disorder (SPD). Yet, it remains unexplored whether childhood trauma predicts symptom load and the level of neurocognitive functioning in SPD. METHOD:We included 225 individuals with SPD and 127 healthy controls. Childhood trauma was evaluated using the Childhood Trauma Questionnaire, and schizotypal traits were assessed using the Schizotypal Personality Questionnaire. Standard neurocognitive assessments covered six cognitive domains. RESULTS:All types of reported childhood trauma were significantly associated with SPD, in a linear fashion. Severe sexual abuse showed the greatest magnitude of association with higher cognitive-perceptual load (e.g., ideas of reference, odd belief or magical thinking); severe emotional neglect was associated with interpersonal scores (e.g., excessive social anxiety, constricted affect) within the SPD group. SPD individuals who reported severe trauma showed worse cognitive functioning (i.e., working memory, verbal/visual learning and memory, as well as verbal fluency). CONCLUSIONS:Particular severe childhood trauma types were associated with higher cognitive-perceptual and interpersonal symptoms in SPD, along with worse cognitive functioning. These findings highlight the need for clinicians to enquire about childhood trauma in SPD patients, since unaddressed early adverse experiences may carry long-term negative consequences.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Velikonja T,Velthorst E,McClure MM,Rutter S,Calabrese WR,Rosell D,Koenigsberg HW,Goodman M,New AS,Hazlett EA,Perez-Rodriguez MMdoi
10.1111/acps.13032subject
Has Abstractpub_date
2019-07-01 00:00:00pages
50-64issue
1eissn
0001-690Xissn
1600-0447journal_volume
140pub_type
杂志文章abstract：OBJECTIVE:Electroconvulsive therapy (ECT)-induced hippocampal volume change (HVC) has been repeatedly described in recent years. The similar time course of HVC and ECT-related cognitive effects suggest a relation, that is to date, understudied. This study investigates whether HVC following ECT predicts the change in me...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.13086
更新日期：2019-11-01 00:00:00
abstract：:Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were foun...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1984.tb01210.x
更新日期：1984-09-01 00:00:00
abstract：:The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separa...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1975.tb00001.x
更新日期：1975-03-01 00:00:00
abstract：:This article reports a true prevalence study of demoralization conducted in a kibbutz. This commune, which assures its members all their instrumental needs throughout the individual life span, is probably one of the few of its kind in the world. All adult members (n = 353) of a kibbutz affiliated with the most orthodo...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1990.tb01356.x
更新日期：1990-07-01 00:00:00
abstract：:In a review article parental losses (PL) of children in different age and sex groups are psycho-analytically examined from the view point of the triangular family relationship, cognitive development of the children and their ability to mourn, delinquency, schizophrenia and affective illnesses, and lastly the controver...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0447.1984.tb04511.x
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:This study assessed the manner in which insight influenced schizophrenic patients' evaluation of their objective life conditions and the concurrent validity between patients' and clinicians' assessments of patients' global quality of life. METHOD:Forty out-patients who fulfilled DSM-III-R criteria for schizo...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1999.tb00994.x
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVE:Autism appears to have a strong genetic component. The product of the NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5 (NDUFA5) gene is included in the mitochondrial electron transport chain. METHOD:We performed a case-control study of 235 patients with autism and 214 controls and examined three single-nu...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2010.01600.x
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:The aim of this review is to summarize all data on suicidal behaviour reported in the Bible and to discuss basic implications for medical ethical positions. METHOD:All books of the Jerusalem Bible, including the apocrypha accepted in the Catholic canon, were searched for all cases of suicide, attempted suici...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.2005.00567.x
更新日期：2005-09-01 00:00:00
abstract：:Cerebrospinal fluid levels of radioreceptor assayable insulin-like growth factors (RRA-IGFs) and immunoreactive somatomedin B (SMB) (RIA-B) were determined in apparently healthy individuals and in patients with dementia of the Alzheimer type (AD). The CSF levels of RIA-B and RRA-IGFs did not alter from the healthy con...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1988.tb05193.x
更新日期：1988-06-01 00:00:00
abstract：OBJECTIVE:To investigate all published case reports of torsade de pointes (TdP) induced by psychotropic drugs (PDs) in order to examine the prevalence of risk factors for TdP prior to the drug initiation. METHOD:We found 45 reports on 70 patients with TdP induced by PDs. Each report was analyzed for the presence of ri...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/j.1600-0447.2004.00469.x
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To examine whether the development of tardive dyskinesia (TD) is accompanied by a parallel process of worsening negative symptoms in a longitudinal study. METHOD:A sample of 708 psychotic patients were followed over a period of 2 years, using the Abnormal Involuntary Movement Scale and the Scale for the Asse...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:302 mentally retarded adults, sampled by epidemiological criteria, were examined with regard to epilepsy and psychiatric disorder. Each of the complications was frequent and related to degree and origin of mental retardation. In 55 (18.2%) epilepsy had occurred at some time during their lives, in 25 (8.3%) of these in...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1985.tb02654.x
更新日期：1985-12-01 00:00:00
abstract：:The aim of the study was to differentiate bipolar II, bipolar I and recurrent unipolar depression by their familial load for affective disorders. Eighty bipolar, 108 unipolar, 80 control subjects and interviewed first-degree relatives were diagnosed according to Research Diagnostic Criteria using the Schedule for Affe...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1993.tb03372.x
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVE:There has been increasing concern about extensions to the definition of 'clinical' depression, but little evident investigation as to how clinical and non-clinical depressive states might best be differentiated. This review considers the potential of many candidate symptom and non-symptom parameters. METHOD:...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章,评审
doi：10.1111/acps.12385
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To examine the association between different levels of childhood attention deficit hyperactivity disorder (ADHD) symptoms and sex differences in psychosocial outcomes during adolescence. METHOD:Swedish children (n = 4635) were screened for neuropsychiatric symptoms at age 9 or 12. ADHD symptoms were divided ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.12655
更新日期：2016-12-01 00:00:00
abstract：:This is a prospective study of 150 consecutive outpatients who were either married or divorced. Marriage custom in Saudi Arabia is unique to the culture of that country and several different kinds of marriage are identified: arranged marriage of cousins; marriage of a couple who have not met before consummation; marri...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1988.tb05090.x
更新日期：1988-02-01 00:00:00
abstract：:In this research we investigated the effects of 4 antipsychotic drugs with different anticholinergic components on different memory functions of schizophrenic patients. Drugs were administered in cumulative doses and memory was tested 90 min after each drug was administered. The results show that chlorpromazine and th...
journal_title：Acta psychiatrica Scandinavica
pub_type： 临床试验,杂志文章
doi：10.1111/j.1600-0447.1992.tb01446.x
更新日期：1992-01-01 00:00:00
abstract：:Hopelessness has not been adequately studied in first-episode psychotic patients, although it is already present at the early stages, especially in schizophrenic patients. We have studied 96 neuroleptic-naive psychotic patients (49 schizophrenic patients and 47 other non-affective psychotic patients) over a period of ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1997.tb09900.x
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:The COVID-19 pandemic in Ireland resulted in a nationwide quarantine on March 27, 2020. This study represents the first assessment of rates of anxiety and depression in the general population of Ireland during the pandemic. AIMS:Our first aim was to estimate the probable prevalence rates of generalized anxi...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.13219
更新日期：2020-09-01 00:00:00
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journal_title：Acta psychiatrica Scandinavica
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1600-0447.2004.00350.x
更新日期：2004-09-01 00:00:00
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journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1984.tb01222.x
更新日期：1984-10-01 00:00:00
abstract：:The purpose of this study was to test the transferability of the Marke-Nymann Temperament Scale (MNTS) using the Rasch item analysis. The results showed that the three Sjöbring personality dimensions Validity, Stability, and Solidity measured by the MNTS were without transferability. However, the item analysis demonst...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1978.tb06873.x
更新日期：1978-01-01 00:00:00
abstract：:A previous report by our group and results published by other research groups have indicated a dichotomy in MHPG levels in depressed patients. This study attempted to characterize phenomena associated with this dichotomy in plasma MHPG levels. First, we have noted, at least in female patients, that homogeneity of MHPG...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1989.tb03012.x
更新日期：1989-11-01 00:00:00
abstract：:Time trends for suicide, homicide and accident mortality among the Finnish population 65 years or over in 1951-1979 are presented. From 1951 to 1967 suicide, motor-vehicle accident mortality and overall accident mortality among elderly males tended to follow more or less similar patterns. In 1951-1979 male suicide rat...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1985.tb02588.x
更新日期：1985-08-01 00:00:00
abstract：OBJECTIVE:To evaluate morbidity during long-term follow-up with clinical treatment of affective and schizoaffective disorder subjects followed from hospitalization for first major psychotic episodes. METHODS:We followed adult subjects systematically at regular intervals from hospitalization for first-lifetime episodes...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/acps.13243
更新日期：2021-01-01 00:00:00
abstract：:This article reviews certified suicide in Fiji during the 2-year period from 1971-1972. The data show the much higher incidence of suicide in Fiji Indians than in other races, the incidence in Fiji Indian females being particularly high. The findings on a more detailed sample survey of 50% of the certified cases are p...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1975.tb00032.x
更新日期：1975-09-01 00:00:00
abstract：:Neuroleptic side-effects adversely affect clinical outcome in schizophrenic patients. Clinicians therefore require an understanding of the impact of such side-effects. This study compared psychiatrists' estimates of the prevalence of neuroleptic side-effects and associated distress with schizophrenic patients' reports...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1998.tb09969.x
更新日期：1998-01-01 00:00:00
abstract：:We studied whether regular treatment with tranquilizing and hypnotic drugs among 30,344 twins in Sweden 15-47 years old was associated with robust indicators of poor health. Longitudinal psychiatric diagnoses and subsequent suicides were analyzed with data from cross-sectional health questionnaires. Women were almost ...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1990.tb03072.x
更新日期：1990-12-01 00:00:00
abstract：:Low levels of platelet monoamine oxidase have been found in schizophrenic and bipolar depressive patients. The enzyme activity seems to correlate negatively with certain personality traits (social activity, sensation seeking, hypomania, positive affect and monotony avoidance) which are correlated to some extent with t...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1981.tb00697.x
更新日期：1981-05-01 00:00:00
abstract：:Regional brain glucose metabolism was investigated in healthy volunteers (n = 10) and in drug free schizophrenic patients (n = 20). The metabolism was determined by positron emission tomography (PET) with 11C-glucose as the tracer. Diagnosis of schizophrenia was made according to RDC and DSM III. Eight patients had th...
journal_title：Acta psychiatrica Scandinavica
pub_type： 杂志文章
doi：10.1111/j.1600-0447.1987.tb02933.x
更新日期：1987-12-01 00:00:00
