Abstract:
:A previous report by our group and results published by other research groups have indicated a dichotomy in MHPG levels in depressed patients. This study attempted to characterize phenomena associated with this dichotomy in plasma MHPG levels. First, we have noted, at least in female patients, that homogeneity of MHPG levels, as tested by fitting with a normal curve, can be ruled out. In contrast, in the total population, a dichotomy was less evident in this study; the 2 subgroups, high and low levels of MHPG, partially overlap, and this results in a gaussian distribution. However, based on the hypothesis of a bimodal distribution, as shown by others and not excluded here, it was possible to find some factors associated with heterogeneity. Thus, polarity of depression, sex and age of the patients, age of disease onset and depression score affect MHPG levels. On the other hand, other elements suspected to modify MHPG values, such as the different lengths of the washout period (minimum 10 days), or some medication (chloralhydrate or levomepromazine) required during the washout period, did not show any effect. The aim of this study was to better characterize this peripheral index for its possible use in clinical application.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Karege F,Bovier P,Gaillard JM,Tissot Rdoi
10.1111/j.1600-0447.1989.tb03012.xsubject
Has Abstractpub_date
1989-11-01 00:00:00pages
499-504issue
5eissn
0001-690Xissn
1600-0447journal_volume
80pub_type
杂志文章abstract::The management of 430 patients treated for depressive illness, at the Neuro-Psychiatric Hospital Aro, Abeokuta, Nigeria, has been reviewed. Psychotherapy particularly with tricyclic antidepressants and electroconvulsive therapy were the main methods of treatment, but neuroleptics and anxiolytics were frequently prescr...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb02908.x
更新日期:1987-11-01 00:00:00
abstract::In 1983-1984 the Swedish Committee for the Prevention and Treatment of Depression launched an educational program on the diagnosis and treatment of depressive disorders for all general practitioners on the island of Gotland. The baseline year chosen was 1982 and the immediate effects were evaluated in 1985. In 1988 th...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb03212.x
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, psychiatric comorbidity and suicidal ideation associated with co-occurring non-affective psychosis and panic attacks, compared with non-affective psychosis without panic attacks, in the general population. METHOD:Data were drawn from the National Comorbidity Survey (n = 8098). St...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2002._10424.x
更新日期:2002-01-01 00:00:00
abstract::The results of a 5-year follow-up study of 76 patients in a crisis intervention ward who were suffering from an adjustment reaction (brief or prolonged depressive reaction) according to ICD-9 criteria indicate a rather favorable course and outcome using standardized instruments. Only 17% developed a chronic or severe ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb01426.x
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:We examined the prevalence and determinants of the reasons given for non-adherence to psychiatric medication in a representative community survey. METHOD:We used data for all participants taking oral psychotropic medication (n = 634) from the 2000 British Survey of National Psychiatric Morbidity. RESULTS:Of...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2006.00974.x
更新日期:2007-07-01 00:00:00
abstract::In a catchment area study of 101 first inceptions of schizophrenia, mania and atypical psychoses, women were significantly more likely to have atypical psychosis and men were more likely to have definite schizophrenia. Negative symptoms such as affective flattening and poverty of speech were already present in many ca...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb03182.x
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To systematically review evidence on the efficacy and safety of sleep deprivation (SD) as a treatment option for patients with unipolar or bipolar depression. METHODS:A systematic review according to PRISMA guidelines was conducted. The certainty of evidence was assessed using the GRADE approach. Controlled ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.13253
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:We examine the safety and efficacy of venlafaxine monotherapy in bipolar type II (BP II) patients with major depressive episode (MDE) who were unresponsive to prior lithium monotherapy. We hypothesized that venlafaxine would be superior to lithium with a low hypomanic conversion rate. METHOD:Seventeen patien...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2009.01462.x
更新日期:2010-03-01 00:00:00
abstract::In a randomized double-blind study with parallel group design involving 60 anxious psychoneurotic outpatients, the anxiolytic activity of alprazolam was compared with that of oxazepam. Following a 4 to 7-day placebo washout period, both groups showed a similar and significant response to treatment during the 4-week ac...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1987.tb02830.x
更新日期:1987-05-01 00:00:00
abstract::Genetic factors have long been implicated in the aetiology of bipolar disorder (BD). During the past two decades several linkage studies have been carried out with the aim of identifying major genes. However, remarkable discrepancies in results both between and within studies have constituted a major problem. In order...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.1996.tb10655.x
更新日期:1996-05-01 00:00:00
abstract::Clonazepam (CLN), a benzodiazepine originally used as an anti-epileptic, was tested in schizophrenia in a double blind comparison in combination with haloperidol (HL). Twenty-four schizophrenic inpatients, diagnosed according to DSM III were treated with HL and CLN (Group 1) or HL and placebo (Group 2) for 4 weeks. Th...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1987.tb02942.x
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVE:Depression in bipolar disorder (BipD) requires a therapeutic approach that is from treating unipolar major depressive disorder (UniD), but to date, no reliable methods could separate these two disorders. The aim of this study was to establish the clinical validity and utility of a non-invasive functional MRI-...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12752
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:There are hardly any randomised-controlled trials of structured family interventions for schizophrenia from India. This study attempted to evaluate the impact of a structured psychoeducational intervention for schizophrenia, compared with standard out-patient treatment, on various patient- and caregiver-relat...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0447.2008.01304.x
更新日期:2009-06-01 00:00:00
abstract::The associations between milieu therapists' feelings towards patients and the unit's psychological climate were studied at 21 small treatment homes for severely disturbed psychiatric patients. The milieu therapists filled out self-report instruments where they rated their feelings towards patients on a feeling-word ch...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1996.tb10650.x
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. METHOD:Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/acps.12838
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The neurodevelopmental hypothesis of psychosis suggests that disrupted white matter (WM) maturation underlies disease onset. In this longitudinal study, we investigated WM connectivity and compared WM changes between individuals at ultra-high-risk for psychosis (UHR) and healthy controls (HCs). METHOD:Thirty...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12835
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:In this paper we review critically the current status of neurocognitive studies in patients with chronic fatigue syndrome (CFS). METHOD:CFS literature was monitored as part of a large research project which involved several neuropsychological and psychopathological studies. The literature survey was the resu...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0447.2001.00017.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:Cognitive reserve (CR) refers to the brain's capacity to cope with pathology in order to minimize the symptoms. CR is associated with different outcomes in severe mental illness. This study aimed to analyze the impact of CR according to the diagnosis of first-episode affective or non-affective psychosis (FEP)...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1111/acps.12949
更新日期:2018-11-01 00:00:00
abstract::Combined data from double-blind risperidone studies were used to analyse the severity of extrapyramidal symptoms (EPS) associated with treatment in patients with chronic schizophrenia. Factors associated with maximum EPS severity were increasing risperidone dose (< or = 8 mg/day was similar to placebo), lower baseline...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1999.tb00972.x
更新日期:1999-03-01 00:00:00
abstract::Pneumoencephalography (PEG) was carried out in 50 patients of both sexes consecutively discharged from a psychiatric department with a diagnosis of acute schizophrenia. At clinical follow-up with a mean observation time of 8 years the diagnosis was verified in 38 patients, while 12 were considered to have had a reacti...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1982.tb06719.x
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To examine the association between physical and mental disorders and the separate and joint effect of physical and mental disorders on work-loss. METHOD:Data was derived from the Netherlands Mental Health Survey and Incidence Study. This was a general population study in which 7076 adults, aged between 18 an...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00513.x
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:Academic performance in youth, measured by grade point average (GPA), predicts suicide attempt, but the mechanisms are not known. It has been suggested that general intelligence might underlie the association. METHODS:We followed 26 315 Swedish girls and boys in population-representative cohorts, up to maxim...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12817
更新日期:2018-04-01 00:00:00
abstract::Five different strategies were used to detect cases in which depressed behaviour occurred in both spouses within the same time period (simultaneous depression). Among 7068 references on depression in the literature, only one referred to a case of simultaneous depression. Of 8008 registered individuals hospitalized in ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb05482.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To compare neurological soft signs (NSS) in patients of schizophrenia with onset in childhood (COS), adolescence (AdOS) and adulthood (AOS). METHOD:Assessment of NSS in 15 patients of COS and 20 patients each of AdOS and AOS was made using condensed neuropsychiatric examination for NSS. RESULTS:NSS were sig...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2006.00901.x
更新日期:2007-04-01 00:00:00
abstract::A representative selection of 2,283 persons, 18-65 years old in "former" Stockholm County were examined by psychiatrists in 1970-71. The total non-response was 12%. The 12-month prevalence of mental disorders in relation to social class (I-III), marital status and immigration was estimated. The "psychiatric diagnoses ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb01262.x
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVE:The idea of cortical surface anomalies in subjects with intellectual disability (mental retardation) and schizophrenia can be traced back to early 20th century qualitative observations. Since it is unknown whether modern quantitative measures of cortical complexity and folding would retrieve those early empir...
journal_title:Acta psychiatrica Scandinavica
pub_type: 历史文章,杂志文章
doi:10.1111/acps.12243
更新日期:2014-09-01 00:00:00
abstract::Based on the theory of Henry & Short, it was predicted that suicide rates should be higher and homicide rates lower in countries where the quality of life is better. In 1980, for a sample of 43 countries, this prediction was confirmed for some components of the quality of life (psychological well-being) but not for ot...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb05459.x
更新日期:1990-04-01 00:00:00
abstract::This study set out to describe the sexual attitudes and behaviour of 50 hospitalized alcoholic men by comparing them with a sample of the general population, matched in age and social class. This control sample was identified by random selection from a company register, and subjects were recruited into the study with ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1978.tb00236.x
更新日期:1978-10-01 00:00:00
abstract::Australian death certificate data were analysed to determine whether they can provide useful information on regional differences in the prevalence of dementia. Strong differences between the Australian states were found in the prevalence of dementing disorders at death. However, evidence indicated that death certifica...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1989.tb08585.x
更新日期:1989-02-01 00:00:00
abstract::302 mentally retarded adults, sampled by epidemiological criteria, were examined with regard to epilepsy and psychiatric disorder. Each of the complications was frequent and related to degree and origin of mental retardation. In 55 (18.2%) epilepsy had occurred at some time during their lives, in 25 (8.3%) of these in...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb02654.x
更新日期:1985-12-01 00:00:00