The heterogeneity of 3-methoxy-4-hydroxyphenylglycol levels among depressed patients.

Abstract:

:A previous report by our group and results published by other research groups have indicated a dichotomy in MHPG levels in depressed patients. This study attempted to characterize phenomena associated with this dichotomy in plasma MHPG levels. First, we have noted, at least in female patients, that homogeneity of MHPG levels, as tested by fitting with a normal curve, can be ruled out. In contrast, in the total population, a dichotomy was less evident in this study; the 2 subgroups, high and low levels of MHPG, partially overlap, and this results in a gaussian distribution. However, based on the hypothesis of a bimodal distribution, as shown by others and not excluded here, it was possible to find some factors associated with heterogeneity. Thus, polarity of depression, sex and age of the patients, age of disease onset and depression score affect MHPG levels. On the other hand, other elements suspected to modify MHPG values, such as the different lengths of the washout period (minimum 10 days), or some medication (chloralhydrate or levomepromazine) required during the washout period, did not show any effect. The aim of this study was to better characterize this peripheral index for its possible use in clinical application.

journal_name

Acta Psychiatr Scand

authors

Karege F,Bovier P,Gaillard JM,Tissot R

doi

10.1111/j.1600-0447.1989.tb03012.x

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

499-504

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

80

pub_type

杂志文章
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    doi:10.1111/j.1600-0447.1992.tb03212.x

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  • Panic attacks in psychosis.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb01426.x

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  • Gender differences in the incidence of definite schizophrenia and atypical psychosis--focus on negative symptoms of schizophrenia.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03182.x

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    更新日期:1991-12-01 00:00:00

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    doi:10.1111/acps.13253

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    更新日期:2021-01-01 00:00:00

  • Venlafaxine monotherapy in bipolar type II depressed patients unresponsive to prior lithium monotherapy.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

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    更新日期:2010-03-01 00:00:00

  • A double-blind study of alprazolam and oxazepam in the treatment of anxiety.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

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  • A systematic evaluation of linkage studies in bipolar disorder.

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    pub_type: 杂志文章,评审

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  • Clonazepam/haloperidol combination therapy in schizophrenia: a double blind study.

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    pub_type: 临床试验,杂志文章

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  • Clinical utility of a short resting-state MRI scan in differentiating bipolar from unipolar depression.

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    pub_type: 杂志文章

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    authors: Li M,Das T,Deng W,Wang Q,Li Y,Zhao L,Ma X,Wang Y,Yu H,Li X,Meng Y,Palaniyappan L,Li T

    更新日期:2017-09-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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  • Psychological climate and countertransference in psychiatric treatment homes.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1996.tb10650.x

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    更新日期:1996-04-01 00:00:00

  • Religiosity and psychological resilience in patients with schizophrenia and bipolar disorder: an international cross-sectional study.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2018-04-01 00:00:00

  • White matter maturation during 12 months in individuals at ultra-high-risk for psychosis.

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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1982.tb06719.x

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    更新日期:1982-11-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    更新日期:2018-04-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1990.tb05482.x

    authors: Holte A,Bjoru E,Sorvig BS,Abrahamsen P

    更新日期:1990-05-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2007-04-01 00:00:00

  • Prevalence of mental disorder in an urban population in central Sweden in relation to social class, marital status and immigration.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1985.tb01262.x

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  • 1910s' brains revisited. Cortical complexity in early 20th century patients with intellectual disability or with dementia praecox.

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    doi:10.1111/j.1600-0447.1978.tb00236.x

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    doi:10.1111/j.1600-0447.1985.tb02654.x

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