Changes in negative symptoms and the risk of tardive dyskinesia: a longitudinal study. UK700 Group.

Abstract:

OBJECTIVE:To examine whether the development of tardive dyskinesia (TD) is accompanied by a parallel process of worsening negative symptoms in a longitudinal study. METHOD:A sample of 708 psychotic patients were followed over a period of 2 years, using the Abnormal Involuntary Movement Scale and the Scale for the Assessment of Negative Symptoms (SANS). RESULTS:Of 361 individuals with no prior evidence of dyskinesia, 46 (13%) developed TD by year 2. Independent of the effects of male sex (odds ratio (OR)=2.18, 95% confidence interval: 1.00-4.74), age (OR per quartile group = 1.39, 95% CI: 1.01-1.90), duration of exposure to antipsychotic medication (OR = 2.35 per 8 months, 95% CI: 1.17-4.72) and average SANS score (OR per quartile group = 1.38, 95% CI: 0.99-1.93), worsening of negative symptoms over the 2 previous years was associated with TD onset (OR per quartile group = 1.46, 95% CI: 1.07-2.00). CONCLUSION:The development of TD is linked, independent of the effect of antipsychotics and older age, to an illness-related pathological process, characterized by worsening negative symptoms.

journal_name

Acta Psychiatr Scand

authors

van Os J,Walsh E,van Horn E,Tattan T,Bale R,Thompson SG

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

300-6

issue

4

eissn

0001-690X

issn

1600-0447

journal_volume

101

pub_type

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    pub_type: 杂志文章,多中心研究

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