Long-term effectiveness of risperidone and olanzapine in resistant or intolerant schizophrenic patients. A mirror study.

Abstract:

OBJECTIVE:To evaluate the long-term effectiveness of the second generation antipsychotics, risperidone and olanzapine on hospitalization, clinical response, and adherence to therapy after switching from conventional antipsychotics or clozapine in a naturalistic setting of schizophrenic patients. METHOD:Data were registered for periods of identical duration before and after switching. RESULTS:Fifty-seven patients were included. Mean study period was 3.1 +/- 0.2 years. Mean number of in-patient days after switching declined by 78% of the level before switching (P=0.0002). There was no significant differences in ratio responders/non-responders between the subgroups. The number of patients with extrapyramidal symptoms (EPS) was significantly reduced after switching. However, intolerable weight gain led to a lack of adherence to therapy in 18% of the olanzapine-treated patients. CONCLUSION:Long-term treatment with the second generation antipsychotics, risperidone and olanzapine significantly improved the clinical outcome. However, weight gain may be a significant reason for discontinuation of treatment and reducing the long-term adherence to therapy.

journal_name

Acta Psychiatr Scand

authors

Søholm B,Lublin H

doi

10.1034/j.1600-0447.2003.00063.x

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

344-50

issue

5

eissn

0001-690X

issn

1600-0447

pii

063

journal_volume

107

pub_type

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