Abstract:
OBJECTIVE:Examine the effects of obesity and metabolic syndrome on outcome in bipolar disorder. METHOD:The Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer and a Classic Mood Stabilizer for Bipolar Disorder (Bipolar CHOICE) study randomized 482 participants with bipolar disorder in a 6-month trial comparing lithium- and quetiapine-based treatment. Baseline variables were compared between groups with and without obesity, with and without abdominal obesity, and with and without metabolic syndrome respectively. The effects of baseline obesity, abdominal obesity, and metabolic syndrome on outcomes were examined using mixed effects linear regression models. RESULTS:At baseline, 44.4% of participants had obesity, 48.0% had abdominal obesity, and 27.3% had metabolic syndrome; neither obesity, nor abdominal obesity, nor metabolic syndrome were associated with increased global severity, mood symptoms, or suicidality, or with poorer functioning or life satisfaction. Treatment groups did not differ on prevalence of obesity, abdominal obesity, or metabolic syndrome. By contrast, among the entire cohort, obesity was associated with less global improvement and less improvement in total mood and depressive symptoms, suicidality, functioning, and life satisfaction after 6 months of treatment. Abdominal obesity was associated with similar findings. Metabolic syndrome had no effect on outcome. CONCLUSION:Obesity and abdominal obesity, but not metabolic syndrome, were associated with less improvement after 6 months of lithium- or quetiapine-based treatment.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
McElroy SL,Kemp DE,Friedman ES,Reilly-Harrington NA,Sylvia LG,Calabrese JR,Rabideau DJ,Ketter TA,Thase ME,Singh V,Tohen M,Bowden CL,Bernstein EE,Brody BD,Deckersbach T,Kocsis JH,Kinrys G,Bobo WV,Kamali M,McInnis MGdoi
10.1111/acps.12460subject
Has Abstractpub_date
2016-02-01 00:00:00pages
144-153issue
2eissn
0001-690Xissn
1600-0447journal_volume
133pub_type
杂志文章abstract::The platelet levels of serotonin and the amino acids aspartic acid, glutamine, glutamic acid and gamma-aminobutyric acid were measured in 18 drug-free autistic (DSM-III criteria) and 14 age-matched healthy children. Serotonin was significantly increased while the amino acids aspartic acid, glutamine, glutamic acid and...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1993.tb03378.x
更新日期:1993-05-01 00:00:00
abstract::Clonidine (0.15 mg intravenously), an alpha-adrenergic receptor agonist, was administered to 13 male chronic schizophrenics, who had been withdrawn from chronic neuroleptic therapy, and to 18 normal male controls. There was no significant difference in growth hormone (GH) response between the two groups. There was no ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb06985.x
更新日期:1983-08-01 00:00:00
abstract::In a double-blind study the effects of a 14-day lithium medication (dosage: 24 mval/day to 36 mval/day) were investigated. The subjects were 24 healthy male volunteers. The effect of lithium on their mood, ability to learn nouns, and memory of the words learnt was measured after 2 hours and 14 days. In spite of a rela...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1979.tb06951.x
更新日期:1979-01-01 00:00:00
abstract::This article reviews certified suicide in Fiji during the 2-year period from 1971-1972. The data show the much higher incidence of suicide in Fiji Indians than in other races, the incidence in Fiji Indian females being particularly high. The findings on a more detailed sample survey of 50% of the certified cases are p...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1975.tb00032.x
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVE:Schizophrenia is a severe mental disorder. Its prevalence appears inconsistent in different regions of China; thus, we conducted this meta-analysis to estimate the prevalence of schizophrenia in mainland China. METHOD:Studies on the prevalence of schizophrenia in mainland China were identified from electroni...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1111/acps.12296
更新日期:2014-10-01 00:00:00
abstract::A new method of treatment of vaginismus by using intravenous diazepam abreaction interviews is reported. Four patients between the ages of 19 and 28 were interviewed. The duration of their main complaint varied from 6 months to 3 years. Three to six abreaction interviews were conducted; the maximum dosage of Valium us...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1976.tb00080.x
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVE:To examine age, period and cohort effects on Australian suicide rates. METHOD:Male suicide rates for successive 5-year periods between 1919 and 1998, and for 1999 were displayed graphically to examine interactions between age, period and cohort effects. RESULTS:There has been a pronounced period effect on m...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2002.1193.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:Lithium-neuroleptics induced encephalopathy is a rare drug interaction. Here I am reporting a patient who developed reversible encepatholopathy with lithium-risperidone combination. METHOD:A single case report. RESULT:A patient of bipolar disorder, who presented with manic symptoms with psychotic feature, s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2008.01165.x
更新日期:2008-05-01 00:00:00
abstract::It is 9 years since the mental health reform was passed by the Italian Parliament. The author presents a data-based evaluation of the effects of the Italian mental health reform. There are still many problems to be resolved: More than 30,000 inpatients are still in psychiatric hospitals and little is known of the fate...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb05163.x
更新日期:1988-05-01 00:00:00
abstract::This paper presents an analysis of the impact of the psychiatric reform in Italy on health care delivery by the general practitioner. In an urban district of the Veneto region a survey was made on the opinions and assessments of the general practitioner about the new status of psychiatric care, on the psychiatric case...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02679.x
更新日期:1986-03-01 00:00:00
abstract::The aim of this study was to find out whether there are any similarities between cannabis psychosis on the one hand and schizophrenia and mania on the other, and to delineate any consistency in the pattern of clinical symptoms of cannabis psychosis. Relevant data were collected from patient's case-notes depicting biog...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb07378.x
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:Evidence based on controlled studies is still limited for treatment strategies that prevent recurrence of suicide attempts. Findings from observational as well as meta-analytic studies strongly suggest that lithium may have suicide-protective properties. METHOD:Patients with a recent suicide attempt in the c...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1600-0447.2008.01266.x
更新日期:2008-12-01 00:00:00
abstract::In a prospective study a number of women and their husbands were interviewed early on in the pregnancy, in the week after delivery and again 4 months later. The couvade syndrome, in which the father-to-be suffers from somatic symptoms of psychogenic origin connected in some way with his wife's pregnancy, was investiga...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb06981.x
更新日期:1983-07-01 00:00:00
abstract::A total of 1070 men and women aged 65 years and over living in the community in Liverpool were interviewed using the Geriatric Mental State. Diagnoses of depression at case and subcase level were made using the GMS-AGECAT package from an initial interview and at follow-up three years later. Data relating to blood pres...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0447.1995.tb09752.x
更新日期:1995-02-01 00:00:00
abstract::The recurrent psychoses, rather than, as Kraepelin supposed, constituting 2 major entities, manic depressive illness and schizophrenia, as separate diseases, may be distributed along a continuum that extends from unipolar depressive illness through bipolar and schizoaffective psychosis to schizophrenia with increasing...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.1990.tb05471.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:Prevalence rates for dissociative disorders among psychiatric in-patients vary widely. The aim of this meta-analysis is to offer an explanation for these differences. METHOD:Prevalence studies using a clinical diagnostic interview among psychiatric in-patients were included. Hypotheses concerning the impact ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1034/j.1600-0447.2000.102006423.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To explore the possibility that autism, catatonia and psychoses in children are different manifestations of a single underlying form of brain pathology - a kind of 'Iron Triangle' of symptomatology - rather than three separate illnesses. METHOD:Systematic evaluation of historical case literature on autism to...
journal_title:Acta psychiatrica Scandinavica
pub_type: 历史文章,杂志文章
doi:10.1111/acps.12082
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To examine the association between preeclampsia and attention-deficit hyperactivity disorder (ADHD), using a large Swedish-based registry cohort. METHODS:This study comprised 2 047 619 children, with 114 934 (5.6%) cases of ADHD. Preeclampsia was based on two alternate definitions: (i) preeclampsia (using IC...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13162
更新日期:2020-10-01 00:00:00
abstract::Interviews were conducted with 21 patients classified as neurotic or prepsychotic/psychotic, consecutively admitted to an intensive care unit (ICU) owing to suicide attempts by means of drug intoxication, with their 37 significant others and with care personnel concerning the patients' contacts with psychiatric, somat...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1987.tb02803.x
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:The relationship between insight and neurocognition in bipolar disorder has not been clearly established. METHOD:A neuropsychological battery assessing attention, mental control, perceptual-motor skills, executive functions, verbal fluency and abstraction, and visuo-spatial attention was administered to 50 b...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2007.01110.x
更新日期:2008-01-01 00:00:00
abstract::A study of suicide among the nonnomadic Gypsies in three counties in Hungary revealed that they had a lower completed suicide rate but a higher attempted suicide rate than ethnic Hungarians. The rate of attempted suicide appeared to be higher in the younger, partially assimilated Gypsies as a result of the conflict be...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb01405.x
更新日期:1990-11-01 00:00:00
abstract::This article reports a true prevalence study of demoralization conducted in a kibbutz. This commune, which assures its members all their instrumental needs throughout the individual life span, is probably one of the few of its kind in the world. All adult members (n = 353) of a kibbutz affiliated with the most orthodo...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb01356.x
更新日期:1990-07-01 00:00:00
abstract::The aim of this study was to elucidate the influence of various events in childhood on suicidal behavior in adult age. For this purpose, 99 patients admitted to the Department of Psychiatry of Odense University Hospital after making a suicide attempt were followed for 5 years, to register repeated suicidal behavior. T...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1991.tb05505.x
更新日期:1991-01-01 00:00:00
abstract::Eleven children who had received a diagnosis of elective mutism upon admission to the children's psychiatric clinic, were followed up 8--18 years later. The average age upon admission was 9 1/2 years, and at the time of follow-up, 23 years. Nine of the children came from homes with a strong familial shyness and reserv...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1979.tb06962.x
更新日期:1979-02-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the treatment incidence, diagnostic stability and clinical and social outcome of affective disorders in the Greenlandic population. METHODS:A cohort of Greenlanders first hospitalized in 1980-1983 and diagnosed with an affective disorder at least once during the period ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1999.tb10892.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To compare the prevalence of Toxoplasma infection between the first-episode schizophrenia and the controls and to compare the clinical features between the Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia. METHOD:The rate of serum reactivity to Toxoplasma in 600 schizophrenia, ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2006.00780.x
更新日期:2006-07-01 00:00:00
abstract::A hypothesis of selective predisposition for drepression, neurasthenic syndrome and anxiety states has been tested in a prospective study. The primary material for the investigation consisted of 4,000 city inhabitants who had registered a private car. Almost all of these could be invited to a group investigation by qu...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1975.tb00214.x
更新日期:1975-02-01 00:00:00
abstract:OBJECTIVE:Subthreshold perceptual abnormalities are commonly used to identify individuals at clinical high risk (CHR) for developing a psychotic disorder. Predictive validity for modality-specific perceptual abnormality severity on psychosis risk is unknown. METHODS:We examined prospectively collected data from 164 in...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13078
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:Schizophrenia is associated with alterations in blood inflammatory markers, including cytokines. Total white blood cell (WBC) count is a marker of low-grade inflammation. We conducted a meta-analysis of total and differential WBC counts in patients with schizophrenia. METHOD:Articles were identified through ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13140
更新日期:2020-07-01 00:00:00
abstract::Salivary secretion was measured in 54 psychiatric patients comprising four diagnostic groups: schizophrenia, mania, depression and anxiety state. Detailed psychometric assessment was carried out at the time of measurement. Although salivary flow failed to show an association with either diagnostic category or mental s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1979.tb00253.x
更新日期:1979-05-01 00:00:00