The effects of lithium on neuroendocrine function in affectively ill patients.

Abstract:

:Lithium is the primary treatment for manic-depressive illness. The mechanism of action of lithium and its endocrine effects remain unclear. Therefore, the hormone responses to sequential stimuli, namely arginine, TRH, and LHRH, were studied in eight patients with major depression before and during treatment with lithium. The drug was found to elevate baseline TSH and prolactin and to augment both their responses to TRH. No clinically significant effect on sex hormones was noted. The advantages of the experimental design and the implications of the findings for lithium's mechanism of action are discussed.

journal_name

Acta Psychiatr Scand

authors

Joffe RT,Post RM,Ballenger JC,Rebar R,Gold PW

doi

10.1111/j.1600-0447.1986.tb02720.x

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

524-8

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

73

pub_type

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