Abstract:
:To explore and to compare hypothalamic-pituitary-somatotropic (HPS), hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenocortical (HPA) axis function in depression, 30 subjects (15 patients with a major depressive episode and individually matched controls) received 50 micrograms growth hormone-releasing hormone-44 amide at 9:00, 200 micrograms thyrotropin-releasing hormone (TRH) at 9:00 and 100 micrograms human corticotropin-releasing hormone (CRH) at 18:00 on consecutive days as an i.v. bolus dose. Compared with controls, depressed patients showed blunted growth hormone (GH) responses to GHRH, decreased TRH-induced thyrotropin (TSH) release and reduced corticotropin (ACTH) but normal cortisol secretion following CRH. ACTH secretion following CRH and TRH-induced TSH release were positively correlated across depressed patients and controls but no significant correlations between GH responses to GHRH and TRH-induced TSH release or ACTH and cortisol secretion following CRH administration were demonstrated. Our findings suggest that altered HPT and HPA axis function associated with depression are triggered by factors that are at least partly different from those that cause HPS system dysfunction. We conclude that the pathophysiological process resulting in aberrant neuroendocrine secretory dynamics associated with depression may primarily occur at a suprapituitary site, and that HPS, HPT and HPA axis dysfunction may be precipitated by complex central and peripheral regulatory mechanisms involving largely independent factors.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Lesch KP,Müller U,Rupprecht R,Kruse K,Schulte HMdoi
10.1111/j.1600-0447.1989.tb10308.xsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
597-602issue
6eissn
0001-690Xissn
1600-0447journal_volume
79pub_type
杂志文章abstract::A study of the extent of homelessness among 1581 psychiatric patients in Copenhagen found that 342 patients (22%) in contact with the psychiatric services had serious housing problems. A total of 112 (7%) were long-stay patients without a home address, 134 (8%) were in an unstable housing situation and 96 (6%) were ac...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb10324.x
更新日期:1992-05-01 00:00:00
abstract::Genetic factors have long been implicated in the aetiology of bipolar disorder (BD). During the past two decades several linkage studies have been carried out with the aim of identifying major genes. However, remarkable discrepancies in results both between and within studies have constituted a major problem. In order...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0447.1996.tb10655.x
更新日期:1996-05-01 00:00:00
abstract::Dexamethasone suppression test (DST) and thyrotropin releasing hormone (TRH) stimulation test were performed in 34 patients with endogenous depression. Compared with 33 psychiatric controls (limit of discrimination for serum cortisol of 275 nmol/l = 10 micrograms/100 ml) the specificity of the DST was 91% and the sens...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb06739.x
更新日期:1983-04-01 00:00:00
abstract::Sleep disturbances commonly occur in the premenstruum in both Premenstrual Syndrome (PMS) patients and in women from the general population. Reports on the Post-Sleep Inventory were obtained from a clinic sample of PMS patients and samples from the general population dichotomized into a non-clinic group with and witho...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06304.x
更新日期:1988-07-01 00:00:00
abstract::Ten patients with manic psychosis were compared with 20 normal subjects with respect to their ratings of emotional meaning in music. As stimulus two pieces of music for a small symphony orchestra were used. These were structurally identical but performed at two different tempos: slow and fast. The change in tempo was ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1982.tb00825.x
更新日期:1982-02-01 00:00:00
abstract:OBJECTIVE:The current study aimed to compare specific cognitive profiles corresponding to auditory verbal hallucinations (AVH) status and elucidate which pattern of cognitive deficits may predict voice-hearing status. METHOD:Clinical participants with schizophrenia spectrum disorders were partitioned into: (i) current...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13169
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To record risk factors for breast cancer in women with schizophrenia and recommend preventive actions. METHOD:A PubMed literature search (from 2005 to 2010) was conducted, using the search terms 'schizophrenia', 'antipsychotics', 'breast cancer' and 'risk factors'. RESULTS:Several risk factors of relevance ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2010.01626.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:The study examined to what degree schizophrenia is characterized by a neuropsychological (NP) test profile specific in shape and level compared with depression and normal functioning. METHOD:Fifty-three patients with schizophrenia, 45 with non-psychotic depression, and 50 normals were assessed with a compreh...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2005.00626.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:While findings are contradictory, many studies report that long Duration of Untreated Psychosis (DUP) correlates with poorer outcome in first episode psychosis. In an outcome study of first-episode psychosis, we compared the patients who refused to participate in a follow-along with those who consented to est...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2004.00381.x
更新日期:2004-10-01 00:00:00
abstract::Abnormal glucose tolerance is often found in patients with anorexia nervosa (AN). We attempted to evaluate pancreatic B-cell functioning after intravenous glucagon administration. Fourteen patients with the restricting type of AN (percentage of ideal body weight 71.5 +/- 1.6%, mean +/- SE) and 6 patients with the buli...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb01433.x
更新日期:1992-01-01 00:00:00
abstract::Thirty-seven, out of a sample of 100 elderly subjects, all suffering from dementia, were found to have delusions. The delusions were more common in women, in patients with a history of psychiatric illness, and amongst those with higher information subscores (Blessed Scale); and were less common in patients suffering f...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb02610.x
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:Employment outcome in bipolar disorder is an under investigated, but important area. The aim of this study was to identify the long-term employment outcomes of people with bipolar disorder. METHOD:A systematic review using the Medline, PsychInfo and Web of Science databases. RESULTS:Of 1962 abstracts retrie...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12087
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between biological rhythms and severity of depressive symptoms in subjects with bipolar disorder and the effects of biological rhythms alterations on functional impairment. METHOD:Bipolar patients (n = 260) and healthy controls (n = 191) were recruited from mood disorders program...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12442
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To provide a clinically useful analysis of the relationship between selective serotonin reuptake inhibitors (SSRIs), in particular fluoxetine and violent or suicidal behaviour. METHOD:All published papers on Medline and other databases linking serotonin, SSRIs and aggression were reviewed. RESULTS:A small p...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1034/j.1600-0447.2001.00357.x
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:Research suggests that group psychotherapy for adults with a history of child sexual abuse (CSA) is generally beneficial. Only few studies have included random assignment. This study compared the effects of analytic (A) and systemic group psychotherapy (S) on CSA. METHOD:One hundred and fifty-one women with ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0447.2006.00977.x
更新日期:2007-08-01 00:00:00
abstract::A total of 289 Greenlanders admitted for the first time to a mental hospital from 1980 to 1983, were followed for 7 years. Thirty-seven patients, 24 men and 13 women, were diagnosed with schizophrenia at least once during the follow-up period. The annual first admission rate per 100,000 was 41 for men and 23 for women...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1995.tb09802.x
更新日期:1995-06-01 00:00:00
abstract::It is 9 years since the mental health reform was passed by the Italian Parliament. The author presents a data-based evaluation of the effects of the Italian mental health reform. There are still many problems to be resolved: More than 30,000 inpatients are still in psychiatric hospitals and little is known of the fate...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb05163.x
更新日期:1988-05-01 00:00:00
abstract::In this study a newly developed Self-rating Inventory for Posttraumatic Stress Disorder (PTSD) is presented. The instrument consists of 47 items, reflecting DSM-III-R criteria, associated features and items corresponding to the disorder of extreme stress not otherwise specified. All items are phrased in a trauma-indep...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1994.tb01574.x
更新日期:1994-09-01 00:00:00
abstract::Despite the atheoretical approach of the DSM-III-R, the personality disorders have their roots in specific theoretical schools. Due to clinical tradition, analogies with Axis I and the tradition in psychiatry and medicine, the personality disorders are presented as categories although there is more empirical support f...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1993.tb03436.x
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:There has been increasing concern about extensions to the definition of 'clinical' depression, but little evident investigation as to how clinical and non-clinical depressive states might best be differentiated. This review considers the potential of many candidate symptom and non-symptom parameters. METHOD:...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12385
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Prevalence rates for dissociative disorders among psychiatric in-patients vary widely. The aim of this meta-analysis is to offer an explanation for these differences. METHOD:Prevalence studies using a clinical diagnostic interview among psychiatric in-patients were included. Hypotheses concerning the impact ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析
doi:10.1034/j.1600-0447.2000.102006423.x
更新日期:2000-12-01 00:00:00
abstract::We conducted a 25-year follow-up study of 50 children of schizophrenic mothers, consisting of 25 children reared by their mothers and 25 children reared apart. The children's adult psychiatric status was evaluated in a 3-h structured interview employing a battery of syndrome check-lists and scales. A slightly higher i...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1997.tb09936.x
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:To examine the psychological substrate of catatonia. METHOD:Reviewing the historical descriptions and explanations of catatonic behaviours by clinicians from its delineation in the 19th century to the present. RESULTS:Patients with catatonia are often haunted by fears and terrors; this has not been widely a...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12796
更新日期:2017-11-01 00:00:00
abstract::The case of an autopsied patient with hypophyseal prolactinoma and dermatozoic delusions is reported, and the mechanism of onset of this special form of delusion is discussed from the neuroendocrinological view point, including response to medications, and neuropathological and pituitary hormonal studies. The subject ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb02641.x
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To study the outcome of a sequential treatment protocol in elderly, severely depressed in-patients. METHOD:All 81 patients from a 12-week double-blind randomized controlled trial (RCT) comparing venlafaxine with nortriptyline were asked to participate in a 3 year follow-up study. Thirty-two patients who did ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0447.2008.01295.x
更新日期:2009-04-01 00:00:00
abstract::The availability of confiding persons both within and outside the household has been investigated in a series of 110 depressed patients and of 98 non-psychiatric controls. The depressive sample has been classified into diagnostic subgroups of unipolar, bipolar, reactive-neurotic and unspecified type of depression. The...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1984.tb01194.x
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:To combine the results of earlier comparison studies of in-patient aggression to quantitatively assess the strength of the association between patient factors and i) aggressive behaviour,ii) repetitive aggressive behaviour. METHOD:A systematic review and meta-analysis of empirical articles and reports of com...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/acps.12053
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Lithium-neuroleptics induced encephalopathy is a rare drug interaction. Here I am reporting a patient who developed reversible encepatholopathy with lithium-risperidone combination. METHOD:A single case report. RESULT:A patient of bipolar disorder, who presented with manic symptoms with psychotic feature, s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2008.01165.x
更新日期:2008-05-01 00:00:00
abstract::This report examines the comorbidity among three key symptoms associated with suicidal intent, namely hopelessness, depression and unusual thinking. A total of 97 out-patients with suicidal thoughts were assessed using the Beck Hopelessness Scale, the anxious depression and unusual thinking factor scales of the Deroga...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1998.tb09978.x
更新日期:1998-02-01 00:00:00
abstract::Renal function was examined in 153 manic-depressive patients treated with lithium for more than 5 years, mean 10 years. No significant change was detectable in plasma creatinine. Glomerular filtration rate (GFR) decreased slightly, but significantly, and not until after 17 years of treatment did the regression line re...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb02534.x
更新日期:1985-04-01 00:00:00