Evaluation of the combination of tryptophan and ECT in the treatment of depression. I. Clinical analysis.

Abstract:

:A double-blind evaluation of the antidepressant efficacy of treatment with a combination of orally administered L-tryptophan (L-TP) and electroconvulsive therapy (ECT) was made in patients suffering from endogenous depression. The patients were randomly assigned to two groups, one treated with L-TP (6 g daily) and unilateral ECT, the other with placebo and unilateral ECT. L-TP treatment was initiated at least 1 day before the first ECT and terminated 4 days after the last ECT. There was a good agreement between the two groups in several measures of antidepressant efficacy: doctors' and patients' ratings of depressive symptoms, and doctors' global rating of therapeutic effect 4 days and 1 month after the last ECT. In the L-TP group, however, there was a significantly better effect on retardation symptoms in the nurses' rating scale. This difference, which is not consistent with other measures of amelioration, contributes, at most, to a marginal therapeutic addition to the antidepressant effect of ECT. It is concluded that oral administration of L-TP, in the dose of 6 g daily, is not of practical value for potentiating the antidepressant efficacy of ECT.

journal_name

Acta Psychiatr Scand

authors

D'Elia G,Lehmann J,Raotma H

doi

10.1111/j.1600-0447.1977.tb00231.x

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

303-18

issue

4

eissn

0001-690X

issn

1600-0447

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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    更新日期:1988-04-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03179.x

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    更新日期:1991-11-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05073.x

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    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1985.tb02547.x

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    更新日期:1985-06-01 00:00:00

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    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1977.tb06676.x

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    更新日期:1977-11-01 00:00:00

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    doi:10.1111/j.1600-0447.1991.tb05534.x

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  • Sexual adjustment of male alcoholics.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1978.tb00236.x

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    更新日期:1978-10-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1992-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1985.tb01269.x

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    更新日期:1985-02-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1984.tb04515.x

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    更新日期:1984-01-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1995.tb09557.x

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1979.tb00550.x

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    更新日期:1979-11-01 00:00:00

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