Polypharmacy among psychiatric patients.

Abstract:

:The purpose of the present study is to determine the frequency of polypharmacy among psychiatric patients in Helsinki, and to ascertain whether this practice is supported by clinical trials. The drugs prescribed in 1 day to a sample of patients (n = 694) in mental hospitals and outpatient clinics in Helsinki were studied. 69% of patients received more than on psychotropic drug in 1 day (61% received "proper" psychotropic drugs). On the average there were 2.1 different psychotropic drugs per patient, and the maximum was 6. A review of controlled clinical trials on the simultaneous use of more than one proper psychotropic drug in psychiatric diseases (excluding fixed combinations) revealed 14 trials. In only three trials was the combination better than its single components or placebo. Thus, there seems to be no evidence from clinical trials defending the frequent polypharmacy. A radical reduction in the number of psychotropic drugs prescribed for psychiatric patients is apparently desirable.

journal_name

Acta Psychiatr Scand

authors

Hemminki E

doi

10.1111/j.1600-0447.1977.tb06676.x

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

347-56

issue

5

eissn

0001-690X

issn

1600-0447

journal_volume

56

pub_type

临床试验,杂志文章
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  • Parental losses.

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    doi:10.1111/j.1600-0447.1984.tb04511.x

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  • Borderline personality disorder in transition age youth with bipolar disorder.

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    pub_type: 杂志文章

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  • Sexual adjustment of male alcoholics.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1978.tb00236.x

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  • Zuclopenthixol decanoate and haloperidol decanoate in chronic schizophrenia: a double-blind multicentre study.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1600-0447.1991.tb01414.x

    authors: Wistedt B,Koskinen T,Thelander S,Nerdrum T,Pedersen V,Mølbjerg C

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  • Pathways to care: help seeking behaviour in first episode psychosis.

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  • Female alcoholics. V: The relationship between family history of alcoholism and outcome 3-10 years after treatment.

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    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1988.tb06402.x

    authors: Nolen WA,van de Putte JJ,Dijken WA,Kamp JS,Blansjaar BA,Kramer HJ,Haffmans J

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    pub_type: 杂志文章

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  • Selection of patients who attempted suicide for psychiatric consultation.

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    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb05520.x

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    更新日期:1991-03-01 00:00:00

  • Attitude of the medical profession to psychiatry.

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0447.1992.tb01432.x

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    更新日期:1992-01-01 00:00:00

  • An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis.

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    journal_title:Acta psychiatrica Scandinavica

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    doi:10.1034/j.1600-0447.2002.01323.x

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  • Co-existence of lycanthropy and Cotard's syndrome in a single case.

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  • Fifty years' development and future perspectives of psychiatric register research.

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    pub_type: 历史文章,杂志文章

    doi:10.1111/acps.12281

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  • Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta-analysis.

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    pub_type: 杂志文章,meta分析,评审

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    pub_type: 杂志文章

    doi:10.1111/acps.12615

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    更新日期:2000-06-01 00:00:00

  • Couvade.

    abstract::In a prospective study a number of women and their husbands were interviewed early on in the pregnancy, in the week after delivery and again 4 months later. The couvade syndrome, in which the father-to-be suffers from somatic symptoms of psychogenic origin connected in some way with his wife's pregnancy, was investiga...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1983.tb06981.x

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    更新日期:1983-07-01 00:00:00

  • Selective serotonin reuptake inhibitors and violence: a review of the available evidence.

    abstract:OBJECTIVE:To provide a clinically useful analysis of the relationship between selective serotonin reuptake inhibitors (SSRIs), in particular fluoxetine and violent or suicidal behaviour. METHOD:All published papers on Medline and other databases linking serotonin, SSRIs and aggression were reviewed. RESULTS:A small p...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0447.2001.00357.x

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    更新日期:2001-08-01 00:00:00

  • Correlates of addiction-related problems in Kuwait: a cross-cultural view.

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    doi:10.1111/j.1600-0447.1988.tb06359.x

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    更新日期:1988-10-01 00:00:00

  • Homicide and major mental disorders: a 25-year study.

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