An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis.

Abstract:

OBJECTIVE:Case of an interstitial deletion of the long arm of chromosome 21 presenting with first episode of psychosis. METHOD:A case report. RESULTS:A 16-year-high school student of Somalian origin presented with a first episode of psychosis, mild mental retardation and dysmorphic features. Chromosome analysis revealed an interstitial deletion in the long arm of chromosome 21, described as 46, XX del (21) (q21q22.1). CONCLUSION:First episode of psychosis occurred in combination with neurobiological vulnerability and a complex genetic inheritance. The occurrence of psychosis in our case may be attributable to genes located within the region 21q21q22.1. The possibility that other loci exist on chromosome 21, which predispose to schizophrenia has to be considered. Identification of susceptibility genes will greatly facilitate investigation of factors that contribute to the disease process and may lead to early intervention and prevention.

journal_name

Acta Psychiatr Scand

authors

Takhar J,Malla AK,Siu V,MacPherson C,Fan YS,Townsend L

doi

10.1034/j.1600-0447.2002.01323.x

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

71-4; discussion 74-5

issue

1

eissn

0001-690X

issn

1600-0447

pii

1c323a

journal_volume

106

pub_type

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