Neuroleptic malignant syndrome during olanzapine and levomepromazine treatment.

Abstract:

OBJECTIVE:To date only five reports of neuroleptic malignant syndrome (NMS) related to olanzapine exist. The first case report was published in November 1998. METHOD:We report the case of a 78-year-old woman suffering from chronic schizophrenia who developed a NMS while being treated with olanzapine and levomepromazine. Before this her medication had been unchanged for more than 2 years. RESULTS:When treated with olanzapine and levomepromazine, the patient had a fulminant NMS which was complicated with pneumonia. When the neuroleptic drug treatment was discontinued, the patient recovered. However, when this combination was restarted later due to severe agitation and hallucinations, the symptoms of NMS reappeared. CONCLUSION:This case report shows that the neuroleptic malignant syndrome can occur during olanzapine treatment as well as during treatment with conventional neuroleptics. This syndrome may develop even after a long and stable neuroleptic treatment.

journal_name

Acta Psychiatr Scand

authors

Järventausta K,Leinonen E

doi

10.1034/j.1600-0447.2000.102003231.x

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

231-3

issue

3

eissn

0001-690X

issn

1600-0447

journal_volume

102

pub_type

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