Risk factors predicting onset and persistence of subthreshold expression of bipolar psychopathology among youth from the community.

Abstract:

OBJECTIVE:To examine factors increasing the risk for onset and persistence of subthreshold mania and depression. METHOD:In a prospective cohort community study, the association between risk factors [a family history of mood disorders, trauma, substance use, attention-deficit/hyperactivity disorder (ADHD) and temperamental/personality traits] and onset of manic/depressive symptoms was determined in 705 adolescents. The interaction between baseline risk factors and baseline symptoms in predicting 8-year follow-up symptoms was used to model the impact of risk factors on persistence. RESULTS:Onset of manic symptoms was associated with cannabis use and novelty seeking (NS), but NS predicted a transitory course. Onset of depressive symptoms was associated with a family history of depression. ADHD and harm avoidance (HA) were associated with persistence of depressive symptoms, while trauma and a family history of depression predicted a transitory course. CONCLUSION:Different risk factors may operate during onset and persistence of subthreshold mania and depression. The differential associations found for mania and depression dimensions suggest partly different underlying mechanisms.

journal_name

Acta Psychiatr Scand

authors

Tijssen MJ,Van Os J,Wittchen HU,Lieb R,Beesdo K,Wichers M

doi

10.1111/j.1600-0447.2010.01539.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

255-66

issue

3

eissn

0001-690X

issn

1600-0447

pii

ACP1539

journal_volume

122

pub_type

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