Abstract:
OBJECTIVE:Antidepressant medications are efficacious overall; however, some individuals experience worsening mood symptoms and increased suicidal ideation (SI) during treatment. We examined the quantitative electroencephalographic (QEEG) cordance biomarker of brain function biomarker in relation to treatment-emergent symptom worsening. METHOD:Seventy-two major depressive disorder (MDD) subjects were treated with fluoxetine 20 mg (n = 13), venlafaxine 150 mg (n = 24), or placebo (n = 35) under double-blind conditions. Behavioral ratings determined whether each subject demonstrated worsening of depressed mood, anxiety, or SI during treatment. QEEG cordance data were analyzed to determine whether symptom worsening was associated with neurophysiological changes. RESULTS:Antidepressant treatment-emergent SI (13.5%) was associated with a large transient decrease in midline-and-right-frontal (MRF) cordance 48 h after start of medication. CONCLUSION:Hypothesis-generating results suggest a pattern of functional changes in midline and right frontal brain regions associated with antidepressant treatment-emergent SI in MDD.
journal_name
Acta Psychiatr Scandjournal_title
Acta psychiatrica Scandinavicaauthors
Hunter AM,Leuchter AF,Cook IA,Abrams Mdoi
10.1111/j.1600-0447.2010.01560.xsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
461-9issue
6eissn
0001-690Xissn
1600-0447pii
ACP1560journal_volume
122pub_type
杂志文章,随机对照试验abstract::The promise of adopting a valid and reliable tool for diagnosing addiction-related problems is offered by the Addiction Severity Index (ASI). Socially determined admissions and poor treatment facilities may have biased the representativeness of our sample, though methodological difficulties were minimal. The ASI was u...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1988.tb06359.x
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:Patients who engage in recurrent deliberate self-harm (DSH) behaviours have increased morbidity and mortality and use emergency services more than others. Unrecognized iatrogenic injury may play a role. Specifically, we call attention to the potential danger of cumulative radiation exposure. METHOD:Case pres...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2010.01538.x
更新日期:2010-11-01 00:00:00
abstract::It has been suggested that serum creatine kinase levels might be useful in the investigation of dementia. In this study serum creatine kinase BB (CKBB) isoenzyme levels were investigated in a community population of elderly women aged 70 to 80 years. Normative data for this group were compared with the findings in you...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1990.tb06440.x
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To explore the possibility that autism, catatonia and psychoses in children are different manifestations of a single underlying form of brain pathology - a kind of 'Iron Triangle' of symptomatology - rather than three separate illnesses. METHOD:Systematic evaluation of historical case literature on autism to...
journal_title:Acta psychiatrica Scandinavica
pub_type: 历史文章,杂志文章
doi:10.1111/acps.12082
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To determine the number of attempts it took before patients with a first episode of psychosis received adequate help, the signs or symptoms that led them to seek help and the people from whom they attempted to seek help. METHOD:Subjects were 86 individuals with a schizophrenia spectrum disorder, mainly schiz...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2002.02004.x
更新日期:2002-11-01 00:00:00
abstract::Recently, provisional research criteria for "schizo-affective" and related psychoses were published by the St. Louis Group. These rigorous criteria were modified and expanded for purposes of the present study in order to analyze the case records of 83 first admissions of Schneider-positive schizophrenics, that is, tho...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1979.tb00284.x
更新日期:1979-10-01 00:00:00
abstract::A prospective study was carried out on 30 patients suffering from a psychotic episode following a stressful life event. They were found to have an Emotional, Timid, Sensitive, Tense and Insecure personality. Sleep disturbance, Affective symptoms, Histrionic behaviour and Excitement were the common clinical features. S...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1980.tb00568.x
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:To evaluate cognitive behaviour therapy for psychosis (CBTp) delivered by non-expert therapists, using CBT relevant measures. METHOD:Participants (N = 74) were randomised into immediate therapy or waiting list control groups. The therapy group was offered 6 months of therapy and followed up 3 months later. T...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0447.2010.01572.x
更新日期:2010-10-01 00:00:00
abstract::This paper presents an analysis of the impact of the psychiatric reform in Italy on health care delivery by the general practitioner. In an urban district of the Veneto region a survey was made on the opinions and assessments of the general practitioner about the new status of psychiatric care, on the psychiatric case...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1986.tb02679.x
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To determine the longitudinal impact of borderline personality disorder (BPD) on the course and outcome of bipolar disorder (BP) in a pediatric BP sample. METHOD:Participants (N = 271) and parents from the Course and Outcome of Bipolar Youth (COBY) study were administered structured clinical interviews and s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12415
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Lycanthropy is an unusual psychiatric syndrome involving the delusion of being an animal. Cotard's syndrome is another rare condition in which the patient has nihilistic delusions and ideation of immortality. We report a psychiatric patient who had both syndromes simultaneously. METHOD:A single case was repo...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.2004.00438.x
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Early diagnosis is important for the course of schizophrenia. AIM:To investigate whether prodromal symptoms of schizophrenia lead to increased use of primary care. METHOD:A register-based cohort study of 21 894 cases with incident schizophrenia and 437 880 matched controls. RESULTS:Cases used daytime prim...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12600
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:Depression in bipolar disorder (BipD) requires a therapeutic approach that is from treating unipolar major depressive disorder (UniD), but to date, no reliable methods could separate these two disorders. The aim of this study was to establish the clinical validity and utility of a non-invasive functional MRI-...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12752
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to further evaluate the oestrogen hypothesis of schizophrenia, which postulates low oestradiol levels to be a risk factor for these disorders. A possible influence of neuroleptic-induced hyperprolactinaemia was to be addressed. METHOD:Sex hormones were measured and cycle phase asses...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.1600-0447.2003.00251.x
更新日期:2004-04-01 00:00:00
abstract::In 1983-1984 the Swedish Committee for the Prevention and Treatment of Depression launched an educational program on the diagnosis and treatment of depressive disorders for all general practitioners on the island of Gotland. The baseline year chosen was 1982 and the immediate effects were evaluated in 1985. In 1988 th...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb03212.x
更新日期:1992-06-01 00:00:00
abstract::Some further results on the effects of the two hypnotic drugs, nitrazepam and flurazepam monohydrochloride, on mood state are described. An automated assessment and scoring system, Computer Assisted Psychometric System (C.A.P.S.), was used to assess mood state and showed that both hypnotics had a mild euphoriant effec...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1975.tb00005.x
更新日期:1975-03-01 00:00:00
abstract::This study set out to describe the sexual attitudes and behaviour of 50 hospitalized alcoholic men by comparing them with a sample of the general population, matched in age and social class. This control sample was identified by random selection from a company register, and subjects were recruited into the study with ...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1978.tb00236.x
更新日期:1978-10-01 00:00:00
abstract::In Scandinavia during the past decade forensic psychiatry has been the subject of discussions, which have occasionally reached the height of vehement attacks. Changes in penal laws have expressed a declining interest in the cooperation of psychiatrists in the evaluation and treatment of offenders. Scandinavian forensi...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1977.tb00154.x
更新日期:1977-03-01 00:00:00
abstract::A total of 440 (50.1%) drinking patients were found in a study of 878 primary care patients in Nigeria, of whom 126 (28.6%) of drinking patients were observed to have alcohol-related problems. Those with alcohol-related problems were significantly more likely to be males, middle-aged and to belong to higher occupation...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1996.tb10640.x
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:It is generally accepted that one of the most important predictors of recurrence in depressive and bipolar disorders is the number of previous episodes. However, very few studies have considered the individual tendency toward recurrence in analyses of the effect of the number of episodes on the risk of subseq...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1046/j.1600-0447.2003.00266.x
更新日期:2004-05-01 00:00:00
abstract::The validity of a questionnaire developed to assess negative attitudes towards drug therapy by relatives of schizophrenic patients is examined. The questionnaire items are tested against the statement: "Patients should not take drugs, they can only be helped by good advice". The prejudice of relatives of schizophrenic...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1985.tb01269.x
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVE:Children of parents with major depression are at significantly increased risk for developing major depression themselves; however, not all children at genetic risk will develop major depressive disorder (MDD). We investigated the utility of subsyndromal scores on the Child Behavior Checklist (CBCL) Anxiety/De...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.12660
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. METHOD:A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphism...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0447.2003.00167.x
更新日期:2003-11-01 00:00:00
abstract::A multi-variate multiple regression analysis was carried out to screen the crucial characteristics of alcohol abusers immediately prior to pension in order to indicate their subsequent trends. Stepwise multiple regression analyses were performed in the younger and older subgroups, as well as in 56 first-time pension a...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb00951.x
更新日期:1983-12-01 00:00:00
abstract:OBJECTIVE:Employment outcome in bipolar disorder is an under investigated, but important area. The aim of this study was to identify the long-term employment outcomes of people with bipolar disorder. METHOD:A systematic review using the Medline, PsychInfo and Web of Science databases. RESULTS:Of 1962 abstracts retrie...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/acps.12087
更新日期:2013-09-01 00:00:00
abstract::Pipamperone was compared double-blindly with placebo to evaluate its capacity to relieve sleep disorders in 40 depressive inpatients. At the end of the 1-week trial, most of the items relating to sleep disturbances had improved significantly in the 24 patients of the pipamperone group whereas only a few items showed s...
journal_title:Acta psychiatrica Scandinavica
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0447.1977.tb00147.x
更新日期:1977-02-01 00:00:00
abstract::The purpose of this study was to determine whether (reported) parental over involvement and lack of affection identify initially healthy subjects at risk for depression. One thousand subjects from the province of Utrecht, the Netherlands were randomly selected by using telephone addresses and asked to participate in a...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1992.tb03265.x
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that not only intrafamiliar childhood abuses inflicted to the patient, but also major losses or other severe life events suffered by the mother within 2 years of patient's birth, are risk factors for the development of dissociative disorders (DDs). METHOD:A multicentric case-control st...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0447.2002.01062.x
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Sleep deprivation (SD) is an antidepressant intervention with multiple administration formats that has been investigated primarily with uncontrolled clinical trials and qualitative reviews of the literature. The validity and applicability of these findings to the treatment of bipolar depression (BPD) is unce...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/acps.13255
更新日期:2020-11-15 00:00:00
abstract::Within the framework of the multifactorial-polygenic model of inheritance, multiple threshold strategy was applied to a large set of pedigree data to examine the clinico-genetical position of some subtypes within the ICD-9 classification of schizophrenic psychoses. It appeared highly probable that the ICD-9 subtypes e...
journal_title:Acta psychiatrica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0447.1983.tb07009.x
更新日期:1983-10-01 00:00:00