No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis.

Abstract:

OBJECTIVE:To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. METHOD:A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. RESULTS:No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. CONCLUSION:The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.

journal_name

Acta Psychiatr Scand

authors

Robertson E,Jones I,Middle F,Moray J,Craddock N

doi

10.1034/j.1600-0447.2003.00167.x

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

387-91

issue

5

eissn

0001-690X

issn

1600-0447

pii

167

journal_volume

108

pub_type

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