A two-phase, double-blind randomized study of three haloperidol plasma levels for acute psychosis with reassignment of initial non-responders.

Abstract:

:To clarify the plasma level/therapeutic response relationship of haloperidol (HPDL) we used a prospective double-blind design in 95 acutely psychotic patients. After drug washout, patients were randomly assigned to a low, middle or high plasma level range for 2 weeks (phase A), and then 50% of the initial non-responders were randomly reassigned into the putative therapeutic range for an additional 2 weeks (phase B). There were no significant differences in clinical outcome between the three plasma level ranges in phase A. However, in phase B initial non-responders displayed greater improvement in the middle range than in the low or the high ranges. No further benefit was observed when plasma levels were raised to or maintained in the high range.

journal_name

Acta Psychiatr Scand

authors

Janicak PG,Javaid JI,Sharma RP,Leach A,Dowd S,Davis JM

doi

10.1111/j.1600-0447.1997.tb09642.x

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

343-50

issue

4

eissn

0001-690X

issn

1600-0447

journal_volume

95

pub_type

临床试验,杂志文章,随机对照试验
  • First admission with puerperal psychosis: 7-14 years of follow-up.

    abstract::The aim of this study was to investigate women who had first-episode psychosis within 1 year after parturition. The Danish Psychiatric Central Register and the Danish Medical Birth Register were linked to identify all women admitted for the first time to a psychiatric department in Arhus County with a psychotic episod...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1995.tb09761.x

    authors: Videbech P,Gouliaev G

    更新日期:1995-03-01 00:00:00

  • Season of birth of schizophrenics in Mississippi, USA.

    abstract::Prior reviews indicate that schizophrenics tend to be born in the winter, relative to non-psychiatric controls. This conclusion has been criticized, however, as the association between birth seasonality and schizophrenia may be the result of a statistical artifact, the age-incidence effect. To examine this possibility...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb03274.x

    authors: Rodrigo G,Lusiardo M,Briggs G,Ulmer A

    更新日期:1992-11-01 00:00:00

  • Substance use in adulthood following adolescent self-harm: a population-based cohort study.

    abstract:OBJECTIVE:To determine whether adolescents who self-harm are at increased risk of heavy and dependent substance use in adulthood. METHOD:Fifteen-year prospective cohort study of a random sample of 1943 adolescents recruited from secondary schools across the state of Victoria, Australia. Data pertaining to self-harm an...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12306

    authors: Moran P,Coffey C,Romaniuk H,Degenhardt L,Borschmann R,Patton GC

    更新日期:2015-01-01 00:00:00

  • Anxiety and EEG alpha activity in neurotic patients.

    abstract::The literature is reviewed on EEG alpha activity in different psychological states, i.e., morbid anxiety, attention and mental relaxation. In the present study, 20 male neurotic inpatients suffering from chronic moderate anxiety were assessed with respect to anxiety level and EEG alpha activity (frequency and per cent...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1975.tb00028.x

    authors: Siciliani O,Schiavon M,Tansella M

    更新日期:1975-08-01 00:00:00

  • Validating an experiential measure of parental style: the use of a twin sample.

    abstract::A study of monozygotic (MZ) and dizygotic (DZ) twins was undertaken to assess further the properties of the Parental Bonding Instrument (PBI), a self-report measure of parental care and overprotection, to examine for associations between PBI and mood (trait anxiety and depression) scores, and to assess the genetic con...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02660.x

    authors: Parker G

    更新日期:1986-01-01 00:00:00

  • Early life experiences and psychiatric disorders: an adoptee study.

    abstract::The aim of this study was to investigate whether there is any correlation between negative experiences in early infancy and the later occurrence of psychiatric disorders. The subjects in this study were a cohort of 2,215 adoptees born 1930-1949. Information about the probands' early experiences has been obtained from ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1982.tb00848.x

    authors: von Knorring AL,Bohman M,Sigvardsson S

    更新日期:1982-04-01 00:00:00

  • The relationship between psychosocial and cognitive functioning in schizophrenic patients and expressed emotion and communication deviance in their parents.

    abstract::The relationship between the family variables of expressed emotion (EE) and communication deviance (CD) and patient attributes of cognitive functions and clinical symptoms were examined. Eleven schizophrenic patients and their parents were evaluated at the beginning and the end of a 2-year treatment programme. The tes...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1994.tb01569.x

    authors: Rund BR

    更新日期:1994-08-01 00:00:00

  • Paranoid states of middle life. Familial occurrence and relationship to schizophrenia.

    abstract::Paranoid states beginning in middle life were selected from a case register. A search among the sibs of those probands uncovered no paranoid states and schizophrenia was no more common than in the general population. The implications for the aetiology of paranoid states and for the relationship between these and schiz...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1980.tb00880.x

    authors: Watt JA,Hall DJ,Olley PC,Hunter D,Gardiner AQ

    更新日期:1980-05-01 00:00:00

  • Long-term neurocognitive functioning after electroconvulsive therapy in patients with late-life depression.

    abstract:OBJECTIVE:There is ongoing concern about the possible negative impact of ECT on neurocognitive functioning in older patients. In this study, we aimed to characterize the long-term cognitive effects of ECT in patients with late-life depression, using an extensive neuropsychological battery. METHODS:A total of 110 patie...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12942

    authors: Obbels J,Verwijk E,Vansteelandt K,Dols A,Bouckaert F,Schouws S,Vandenbulcke M,Emsell L,Stek M,Sienaert P

    更新日期:2018-09-01 00:00:00

  • Does persisting fear sustain catatonia?

    abstract:OBJECTIVE:To examine the psychological substrate of catatonia. METHOD:Reviewing the historical descriptions and explanations of catatonic behaviours by clinicians from its delineation in the 19th century to the present. RESULTS:Patients with catatonia are often haunted by fears and terrors; this has not been widely a...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/acps.12796

    authors: Fink M,Shorter E

    更新日期:2017-11-01 00:00:00

  • Evaluation and interpretation of symptom structures in patients with schizophrenia.

    abstract::Seventy Japanese DSM-III-R schizophrenic patients were assessed for 30 clinical symptoms using the Positive and Negative Syndrome Scale (PANSS) of Kay et al. Principal component analysis was applied to the full item set of this scale and disclosed 5 orthogonal independent symptom groups: negative, hostile/excited, tho...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01536.x

    authors: Kawasaki Y,Maeda Y,Sakai N,Higashima M,Urata K,Yamaguchi N,Kurachi M

    更新日期:1994-06-01 00:00:00

  • Treatment of refractory Tourette syndrome with haloperidol decanoate.

    abstract::A 23-year-old male with a history of severe Tourette syndrome refractory to treatment with oral haloperidol is reported. The Tourette symptoms remitted after treatment with haloperidol decanoate. The response has been maintained over 18 months. ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05159.x

    authors: Clarke DJ,Ford R

    更新日期:1988-04-01 00:00:00

  • Dexamethasone suppression and energy balance in eating disorders.

    abstract::The dexamethasone suppression test (DST) was investigated in 45 female anorectic out-patients (cross sectional study) nine of whom were followed serially as in-patients (longitudinal study). DST non-suppression was strongly associated with negative energy balance (low body weight and low Ponderal Index) but there was ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02681.x

    authors: Abou-Saleh MT,Oleesky D,Crisp AH,Lacey JH

    更新日期:1986-03-01 00:00:00

  • Risk factors of cycle acceleration in acutely admitted patients with bipolar disorder.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12308

    authors: Finseth PI,Morken G,Malt UF,Andreassen OA,Vaaler AE

    更新日期:2014-11-01 00:00:00

  • Morphology of the corpus callosum in treatment-resistant schizophrenia and major depression.

    abstract:OBJECTIVE:To identify possible differences in the mean midsagittal corpus callosum (CC) total and subdivision areas in treatment-resistant schizophrenia and depression (TRS and TRD) patients. METHOD:Areas of the total CC and its five equidistant subregions (from CC1 to CC5) obtained by parallel grid partitioning schem...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2009.01389.x

    authors: Sun J,Maller JJ,Daskalakis ZJ,Furtado CC,Fitzgerald PB

    更新日期:2009-10-01 00:00:00

  • Drug abuse as seen in the University Department of Psychiatry, Kaduna, Nigeria, in 1980-1984.

    abstract::367 new cases of drug abuse and related cases were admitted to the teaching hospital within the study period. These cases comprised approximately 11% of all new admissions during the period. 80% were between 15 and 30 years, and 76% of them were single. People in this age group tend to abuse cannabis and amphetamine m...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06234.x

    authors: Ahmed MH

    更新日期:1986-07-01 00:00:00

  • Quality of life in schizophrenia and dysthymia.

    abstract::Quality of life (QOL) was assessed in three groups of patients, consisting of 30 schizophrenic patients with duration of illness <2 years, 30 schizophrenic patients with duration of illness > or = 2 years and 30 dysthymic patients. The diagnoses were made according to ICD-10. Two scales of quality of life were used, o...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1998.tb10002.x

    authors: Gupta S,Kulhara P,Verma SK

    更新日期:1998-04-01 00:00:00

  • Interaction of affective and cognitive impairments in the suicidal state: a brief elaboration.

    abstract::This report examines the comorbidity among three key symptoms associated with suicidal intent, namely hopelessness, depression and unusual thinking. A total of 97 out-patients with suicidal thoughts were assessed using the Beck Hopelessness Scale, the anxious depression and unusual thinking factor scales of the Deroga...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1998.tb09978.x

    authors: Mendonca JD,Holden RR

    更新日期:1998-02-01 00:00:00

  • The Parental Bonding Instrument in adolescent patients with anorexia nervosa.

    abstract::The Parental Bonding Instrument (PBI) was administered to 54 adolescent patients with anorexia nervosa. Scores were compared with those of matched groups of normal and of nonanorectic adolescents referred for assessment to an adolescent psychiatric unit. Significant differences between the 3 groups were demonstrated w...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb03259.x

    authors: Russell JD,Kopec-Schrader E,Rey JM,Beumont PJ

    更新日期:1992-09-01 00:00:00

  • Bone mineral density, osteoporosis, and fractures among people with eating disorders: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To provide meta-analytical evidence of bone mineral density (BMD), fractures, and osteoporosis rates in eating disorders (ED) vs. healthy controls (HCs). METHOD:Three independent authors searched major electronic databases from inception till August 2015 for cross-sectional studies reporting BMD in people wi...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/acps.12556

    authors: Solmi M,Veronese N,Correll CU,Favaro A,Santonastaso P,Caregaro L,Vancampfort D,Luchini C,De Hert M,Stubbs B

    更新日期:2016-05-01 00:00:00

  • Phobias in India and the United Kingdom. A trans-cultural study.

    abstract::Thirty-nine phobic patients from India were compared with 39 similarly diagnosed age and sex matched patients from the United Kingdom. The British sample contained significantly more patients with agoraphobia and social phobia compared to the Indian group. Sudden death and illness phobias were more frequent in the Ind...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06259.x

    authors: Chambers J,Yeragani VK,Keshavan MS

    更新日期:1986-10-01 00:00:00

  • A double-blind comparison of raclopride and haloperidol in the acute phase of schizophrenia. The British Isles Raclopride Study Group.

    abstract::This is the first comparative double-blind study of raclopride. Ninety-one patients with acute schizophrenia received either raclopride 2-8 mg twice daily or haloperidol 5-20 mg twice daily for 4 weeks. Both neuroleptics produced clinical improvements. There were no significant between-drug differences in overall effi...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1992.tb03286.x

    authors:

    更新日期:1992-11-01 00:00:00

  • The diversity of premenstrual changes as reflected in the Premenstrual Assessment Form.

    abstract::The Premenstrual Assessment Form (PAF) is a new self report procedure designed to measure changes in mood, behavior, and physical condition during the premenstrual period. It reflects the great variability of premenstrual syndromes as opposed to the common practice of viewing these changes as a single entity. In compa...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1982.tb00820.x

    authors: Halbreich U,Endicott J,Schacht S,Nee J

    更新日期:1982-01-01 00:00:00

  • The relationship between DSM-III symptom disorders (Axis I) and personality disorders (Axis II) in an outpatient population.

    abstract::The relationship between symptom disorder and personality disorder according to DSM-III was studied in 289 consecutive outpatients. It was observed that personality disorders occurred frequently among the chronic affective and anxiety disorders. The "dramatic" personality disorders were observed especially frequently ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb06371.x

    authors: Alnaes R,Torgersen S

    更新日期:1988-10-01 00:00:00

  • Service use and costs of people with dual diagnosis in South London.

    abstract:OBJECTIVE:To compare the service use and costs of individuals who have a dual diagnosis of psychosis and substance abuse with those who have a diagnosis of psychosis but no substance abuse. METHOD:Patients with psychosis were identified and a representative sample were interviewed. Six-month service use was measured a...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2000.101006464.x

    authors: McCrone P,Menezes PR,Johnson S,Scott H,Thornicroft G,Marshall J,Bebbington P,Kuipers E

    更新日期:2000-06-01 00:00:00

  • Priapism and neuroleptics: a case report.

    abstract::We present a case of priapism caused by the alpha adrenoreceptor blocking action of a butyrophenone. The problem was solved surgically performing a cavernousspongiosum fistula. ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05086.x

    authors: Morera A,Estrada AG,Valenciano R

    更新日期:1988-01-01 00:00:00

  • Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis.

    abstract::Psychological autopsies are an important research tool in establishing risk factors associated with suicide. We report the results of a validity study comparing psychological autopsy-generated DSM-III-R diagnoses in suicides and non-suicides with chart diagnoses generated by clinicians who had treated the subjects pri...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1996.tb09869.x

    authors: Kelly TM,Mann JJ

    更新日期:1996-11-01 00:00:00

  • Religious psychotherapy in anxiety disorder patients.

    abstract::Religious patients with generalized anxiety disorder were given religious psychotherapy in addition to supportive psychotherapy anxiolytic drugs. Those receiving religious psychotherapy showed significantly more rapid improvement in anxiety symptoms than those who received supportive psychotherapy and drugs only. Thus...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1994.tb01545.x

    authors: Azhar MZ,Varma SL,Dharap AS

    更新日期:1994-07-01 00:00:00

  • Classification of the MMPI profiles of two alcoholic groups.

    abstract::Ninety-two per cent of the MMPI CODES OF 60 ALCOHOLICS IN THE Link Society and institutional groups of the present study were classified according to a mixed typological-dimensional model. The study applied reciprocal two-digit high-point codes and also five different spiked codes and two different codes which includ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1976.tb00132.x

    authors: Kristianson P

    更新日期:1976-11-01 00:00:00

  • Diagnosis change, lithium use and admissions for mania in Edinburgh.

    abstract::Admissions for mania have risen significantly in Edinburgh since 1970. Differencing was used to remove time trends; this showed that the rise was not accounted for by diagnosis change (from schizophrenia or personality disorder) or by lithium prescription. The contribution of non-specific factors such as admission pol...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb03002.x

    authors: Mander AJ

    更新日期:1989-11-01 00:00:00