Increased right amygdala volume in lithium-treated patients with bipolar I disorder.

Abstract:

OBJECTIVE:The amygdala plays a major role in processing emotional stimuli. Fourteen studies using structural magnetic resonance imaging (MRI) have examined the amygdala volume in paediatric and adult patients with bipolar disorder (BD) compared with healthy controls (HC) and reported inconsistent findings. Lithium has been found to increase grey matter volume, and first evidence points towards an effect on regional brain volume such as the amygdala. METHOD:We examined the amygdala volume of euthymic patients with BD treated with lithium (n = 15), without lithium (n = 24) and HC (n = 41) using structural MRI. RESULTS:Patients treated with lithium exhibited in comparison to HC a larger right absolute (+17.9%, P = 0.015) and relative (+18%, P = 0.017) amygdala volume. There was no significant difference in amygdala volume between patients without lithium treatment and HC. CONCLUSION:Lithium appears to have a sustained effect on a central core region of emotional processing and should therefore be considered in studies examining BD.

journal_name

Acta Psychiatr Scand

authors

Usher J,Menzel P,Schneider-Axmann T,Kemmer C,Reith W,Falkai P,Gruber O,Scherk H

doi

10.1111/j.1600-0447.2009.01428.x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

119-24

issue

2

eissn

0001-690X

issn

1600-0447

pii

ACP1428

journal_volume

121

pub_type

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