An association between YKL-40 and type 2 diabetes in psychotic disorders.

Abstract:

OBJECTIVE:This study examines if YKL-40 is increased in individuals with psychotic disorders and if elevated YKL-40 levels at baseline is associated with subsequent development of type 2 diabetes. METHOD:A total of 1383 patients with a diagnosis of schizophrenia or affective psychosis and 799 healthy controls were recruited in the period 2002-2015. Plasma YKL-40 and metabolic risk factors were measured and medication was recorded. Using national registry data, association between baseline risk factors and later development of type 2 diabetes was assessed using Cox proportional hazards models. RESULTS:Plasma YKL-40 was higher in patients vs. healthy controls also after adjusting for metabolic risk factors, with no difference between the schizophrenia and affective psychosis groups. Patients were diagnosed with type 2 diabetes at a significantly younger age. Multivariate Cox regression analyses showed that elevated YKL-40 (hazard ratio (HR) = 5.6, P = 0.001), elevated glucose (HR = 3.6, P = 0.001), and schizophrenia diagnosis (HR = 3.0, P = 0.014) at baseline were associated with subsequent development of type 2 diabetes. CONCLUSIONS:Patients with psychotic disorders have at baseline increased levels of YKL-40 beyond the effect of comorbid type 2 diabetes and metabolic risk factors. Elevated YKL-40 level at baseline is associated with later development of type 2 diabetes.

journal_name

Acta Psychiatr Scand

authors

Dieset I,Mørch RH,Hope S,Hoseth EZ,Reponen EJ,Gran JM,Aas M,Michelsen AE,Reichborn-Kjennerud T,Nesvåg R,Agartz I,Melle I,Aukrust P,Djurovic S,Ueland T,Andreassen OA

doi

10.1111/acps.12971

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

37-45

issue

1

eissn

0001-690X

issn

1600-0447

journal_volume

139

pub_type

杂志文章
  • Reliability of clinical assessment of blunted affect.

    abstract::The affect of 20 chronic schizophrenic in-patients was assessed by two psychiatrists using two rating scales. The interview recordings were reviewed three times--firstly with the auditory information only (the "audio review"), secondly with the visual information only (the "visual review") and thirdly with both (the "...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1984.tb02491.x

    authors: Kitamura T,Kahn A,Kumar R

    更新日期:1984-03-01 00:00:00

  • Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study.

    abstract:OBJECTIVE:To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups. METHOD:By linkage of public hospital registers from 1977 to 1993, three study cohorts were identified: patients with affective disorder...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2001.00372.x

    authors: Nilsson FM,Kessing LV,Bolwig TG

    更新日期:2001-11-01 00:00:00

  • Language of publication of journal articles on suicide and mental disorders.

    abstract::English as the language of publication for articles on suicide in the medical literature increased from 58% of articles in 1966 to 79% in 1986. This increase occurred at the expense of all languages. These changes parallel those for the language of publication of articles on mental disorders and all medical subjects. ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb10253.x

    authors: Barraclough BM,Noyes R

    更新日期:1989-03-01 00:00:00

  • Interhemispheric electroencephalographic coherence as a biological marker in alcoholism.

    abstract::Electroencephalographic coherence scores in 21 teetotaler first-degree relatives of alcoholics, 27 subjects with alcohol dependence and 21 healthy subjects without a family history of alcohol abuse were compared. The relatives had significantly higher coherence scores in the frontal and parietal leads than the alcohol...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03358.x

    authors: Michael A,Mirza KA,Mukundan CR,Channabasavanna SM

    更新日期:1993-03-01 00:00:00

  • Personality and self-variables: important determinants of subjective quality of life in schizophrenia out-patients.

    abstract:OBJECTIVE:To investigate factors determining severely mentally ill patients' self-rated quality of life. The study hypothesized that objective life circumstances, personality, self-variables, and psychopathology would be determinants of quality of life. METHOD:A total of 117 individuals with schizophrenia and related ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2003.00103.x

    authors: Eklund M,Bäckström M,Hansson L

    更新日期:2003-08-01 00:00:00

  • Cognitive reserve as an outcome predictor: first-episode affective versus non-affective psychosis.

    abstract:OBJECTIVE:Cognitive reserve (CR) refers to the brain's capacity to cope with pathology in order to minimize the symptoms. CR is associated with different outcomes in severe mental illness. This study aimed to analyze the impact of CR according to the diagnosis of first-episode affective or non-affective psychosis (FEP)...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,多中心研究

    doi:10.1111/acps.12949

    authors: Amoretti S,Cabrera B,Torrent C,Mezquida G,Lobo A,González-Pinto A,Parellada M,Corripio I,Vieta E,de la Serna E,Butjosa A,Contreras F,Sarró S,Penadés R,Sánchez-Torres AM,Cuesta M,Bernardo M,PEPsGroup.

    更新日期:2018-11-01 00:00:00

  • The state of mental health in old-age across the 'old' European Union-- a systematic review.

    abstract:OBJECTIVE:The paper provides the first syllabus on the prevalence of mental disorders in old-age focusing on surveys conducted in the 15 countries, which comprised the 'old' European Union. METHOD:A systematic search of the literature published from 1990 onwards was conducted. RESULTS:Mental disorders in old-age are ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0447.2005.00632.x

    authors: Riedel-Heller SG,Busse A,Angermeyer MC

    更新日期:2006-05-01 00:00:00

  • Electroconvulsive therapy vs. paroxetine in treatment-resistant depression -- a randomized study.

    abstract::Failure to respond to adequate pharmacological treatment for major depression is now the most common indication for the use of electroconvulsive therapy (ECT). The advantages of ECT with respect to both speed and quality of response are clinically important issues, but surprisingly few studies have examined the effica...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1997.tb09926.x

    authors: Folkerts HW,Michael N,Tölle R,Schonauer K,Mücke S,Schulze-Mönking H

    更新日期:1997-11-01 00:00:00

  • Electrodermal and heart-rate measurements in chronic and partially remitted schizophrenic patients.

    abstract::Electrodermal activity and heart-rate were recorded in the laboratory from partially remitted schizophrenic patients living in the community, chronic schizophrenic inpatients and normal controls. Althoug all patients had faster heart-rates, no consistent electrodermal differences between patient groups and normals wer...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1978.tb06905.x

    authors: Tarrier N,Cooke EC,Lader MH

    更新日期:1978-05-01 00:00:00

  • The association between economic and social factors and mental health in Finland.

    abstract::The aim of the study was to examine the social and economic variables associated with mental health by means of telephone interviews of a randomly chosen population sample (n = 1557) in Finland in 1993. Mental health was evaluated by means of a 12-item General Health Questionnaire. A mental disorder, indicated by the ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1995.tb09570.x

    authors: Viinamäki H,Kontula O,Niskanen L,Koskela K

    更新日期:1995-09-01 00:00:00

  • A two-phase, double-blind randomized study of three haloperidol plasma levels for acute psychosis with reassignment of initial non-responders.

    abstract::To clarify the plasma level/therapeutic response relationship of haloperidol (HPDL) we used a prospective double-blind design in 95 acutely psychotic patients. After drug washout, patients were randomly assigned to a low, middle or high plasma level range for 2 weeks (phase A), and then 50% of the initial non-responde...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1997.tb09642.x

    authors: Janicak PG,Javaid JI,Sharma RP,Leach A,Dowd S,Davis JM

    更新日期:1997-04-01 00:00:00

  • The prescription of psychotropic drugs in primary health care.

    abstract::We followed the prescription of psychotropic drugs by primary health care physicians over a 3-year period. The material consisted of 1000 randomly selected adult primary health care patients. At least one psychotropic drug was prescribed to one third (n = 307) of the sample during the follow-up period. The most common...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1995.tb09597.x

    authors: Joukamaa M,Sohlman B,Lehtinen V

    更新日期:1995-11-01 00:00:00

  • Juvenile bipolar disorder.

    abstract:OBJECTIVE:Bipolar disorder in children and adolescents is less well studied than bipolar disorder in adults. This review addresses issues related to its underdiagnosis, precursors of bipolarity, comorbidity, natural course and treatment. METHOD:Literature from Medline and other searches, and earlier relevant articles ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0447.2000.102003162.x

    authors: Reddy YC,Srinath S

    更新日期:2000-09-01 00:00:00

  • Psychopathological pattern of depression in affective disorders. A cluster analysis.

    abstract::The psychopathological pattern of depression was assessed by means of the Puzyński Inventory Scale for Depression (ISD) in 79 patients with bipolar affective disorders, 45 with unipolar and 42 with undifferentiated type of affective disorders. Four groups of patients showing different psychopathological patterns were ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb10579.x

    authors: Parnowski T

    更新日期:1986-02-01 00:00:00

  • Delirium tremens. Some clinical features. Part I.

    abstract::Twenty patients with delirium tremens and related states were investigated from the time of admission until the acute state was over. Using strict diagnostic criteria the material was divided into two groups according to the severity of the clinical condition; nine patients had fully developed delirium tremens (grade ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1979.tb00550.x

    authors: Kramp P,Hemmingsen R

    更新日期:1979-11-01 00:00:00

  • Clinical aspects of hysteria.

    abstract::This is a clinical study of 80 patients, diagnosed as suffering from hysteria, who attended the psychiatric clinic in Khartoum Hospital over a period of 3 years. The incidence of hysteria was 10%, the female-male ratio 15:1, and young age-groups predominate. 60% were essentially of normal personality. The clinical pic...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02742.x

    authors: Hafeiz HB

    更新日期:1986-06-01 00:00:00

  • A 15-year follow-up study of Chinese schizophrenic patients.

    abstract::A cohort of 330 Chinese schizophrenic patients below age 40 were interviewed 5, 10 and 15 years later to determine which variables could predict their outcome. There were 189 males (57%) and 141 females (43%). At the end of 15 years, 48 (15%) died (34 (10%) from suicide). At the end of 5, 10 and 15 years, the percenta...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03132.x

    authors: Tsoi WF,Wong KE

    更新日期:1991-09-01 00:00:00

  • Endocrine responses to growth hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone in depression.

    abstract::To explore and to compare hypothalamic-pituitary-somatotropic (HPS), hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-adrenocortical (HPA) axis function in depression, 30 subjects (15 patients with a major depressive episode and individually matched controls) received 50 micrograms growth hormone-releas...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb10308.x

    authors: Lesch KP,Müller U,Rupprecht R,Kruse K,Schulte HM

    更新日期:1989-06-01 00:00:00

  • Bimodal distribution of serum trypotphan level.

    abstract::Serum levels of total L-tryptophan (L-TP) were determined before and during treatment in patients suffering from endogenous depression, who were treated with L-TP, 6 g daily, and unilateral electroconvulsive therapy (ECT). The gaussian curve of initial L-TP concentrations changed into a bimodal distribution during tre...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1979.tb00260.x

    authors: d'Elia G,Lehmann J,Raotma H

    更新日期:1979-07-01 00:00:00

  • Cannabis and bipolar disorder: does quitting cannabis use during manic/mixed episode improve clinical/functional outcomes?

    abstract:OBJECTIVE:To examine whether bipolar disorder patients who stop cannabis use during a manic/mixed episode have better clinical and functional outcomes than continued use or never use. METHOD:Data from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM), a 2-year prospective observational study...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12366

    authors: Zorrilla I,Aguado J,Haro JM,Barbeito S,López Zurbano S,Ortiz A,López P,Gonzalez-Pinto A

    更新日期:2015-02-01 00:00:00

  • Homicide and major mental disorders: a 25-year study.

    abstract:OBJECTIVE:This study was designed to investigate the association between major mental disorders (MMDs) and homicide. METHOD:The rates of exculpations because of MMDs among 1087 Austrian homicide offenders during 1975 and 1999 were compared with the rates of the respective disorders in the general population. RESULTS:...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0047.2004.00305.x

    authors: Schanda H,Knecht G,Schreinzer D,Stompe T,Ortwein-Swoboda G,Waldhoer T

    更新日期:2004-08-01 00:00:00

  • Trajectories of posttraumatic growth among US military veterans: a 4-year nationally representative, prospective cohort study.

    abstract:OBJECTIVE:This study examined the nature and determinants of predominant trajectories of posttraumatic growth (PTG) over time. METHOD:Using data from a prospective, nationally representative survey of 2718 US veterans assessed in 2011, 2013, and 2015, we used latent growth mixture modeling to identify PTG trajectories...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12800

    authors: Tsai J,Pietrzak RH

    更新日期:2017-11-01 00:00:00

  • Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs). METHOD:The PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched up until May 30, 2016. Effect sizes were esti...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析

    doi:10.1111/acps.12698

    authors: Köhler CA,Freitas TH,Maes M,de Andrade NQ,Liu CS,Fernandes BS,Stubbs B,Solmi M,Veronese N,Herrmann N,Raison CL,Miller BJ,Lanctôt KL,Carvalho AF

    更新日期:2017-05-01 00:00:00

  • Psychopathology and treatment of 30,344 twins in Sweden. I. The appropriateness of psychoactive drug treatment.

    abstract::We studied whether regular treatment with tranquilizing and hypnotic drugs among 30,344 twins in Sweden 15-47 years old was associated with robust indicators of poor health. Longitudinal psychiatric diagnoses and subsequent suicides were analyzed with data from cross-sectional health questionnaires. Women were almost ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1990.tb03072.x

    authors: Allgulander C,Nowak J,Rice JP

    更新日期:1990-12-01 00:00:00

  • Platelet MAO activity and personality characteristics. A study in schizophrenic patients and normal individuals.

    abstract::Low levels of platelet monoamine oxidase have been found in schizophrenic and bipolar depressive patients. The enzyme activity seems to correlate negatively with certain personality traits (social activity, sensation seeking, hypomania, positive affect and monotony avoidance) which are correlated to some extent with t...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1981.tb00697.x

    authors: Gattaz WF,Beckmann H

    更新日期:1981-05-01 00:00:00

  • Telepsychiatry: assessment of televideo psychiatric interview reliability with present- and next-generation internet infrastructures.

    abstract:OBJECTIVE:We assessed the reliability of remote video psychiatric interviews conducted via the internet using narrow and broad bandwidths. METHOD:Televideo psychiatric interviews conducted with 42 in-patients with chronic schizophrenia using two bandwidths (narrow, 128 kilobits/s; broad, 2 megabits/s) were assessed in...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2001.00236.x

    authors: Yoshino A,Shigemura J,Kobayashi Y,Nomura S,Shishikura K,Den R,Wakisaka H,Kamata S,Ashida H

    更新日期:2001-09-01 00:00:00

  • Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease.

    abstract::We investigated the immune-associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age-matched healthy control subjects using two-color analysis with flow cytometry. Four ratios of immune-related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA-DR, were compared for...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb05573.x

    authors: Ikeda T,Yamamoto K,Takahashi K,Yamada M

    更新日期:1991-06-01 00:00:00

  • Psychiatric disorders in a rural practice in the Bendel State of Nigeria.

    abstract::Patients attending a clinic were ascertained for psychiatric morbidity by a general practitioner and reascertained by a psychiatrist. The agreement ranged from 84% for neurosis and 60% for psychosis. The differences were mainly due to a lack of the depression category in the general practitioner's classification. One ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1981.tb00784.x

    authors: Binitie A

    更新日期:1981-10-01 00:00:00

  • Differentiating 'clinical' and 'non-clinical' depression.

    abstract:OBJECTIVE:There has been increasing concern about extensions to the definition of 'clinical' depression, but little evident investigation as to how clinical and non-clinical depressive states might best be differentiated. This review considers the potential of many candidate symptom and non-symptom parameters. METHOD:...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/acps.12385

    authors: Parker G,Paterson A

    更新日期:2015-06-01 00:00:00

  • A survey of the attitudes of chronic psychiatric patients living in the community toward their medication.

    abstract::Because non-compliance with antipsychotic drug therapy is both common and associated with a substantially increased risk of acute relapse, depot medication must be preferred for most schizophrenic out-patients. Yet there is a perception that depot medication is unpopular among patients. In the survey of out-patients r...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1997.tb10133.x

    authors: Pereira S,Pinto R

    更新日期:1997-06-01 00:00:00