A double-blind randomized placebo-controlled study of the efficacy and safety of pirlindole, a reversible monoamine oxidase A inhibitor, in the treatment of depression.

Abstract:

:The efficacy and safety of pirlindole (300 mg/day), a new reversible inhibitor of monoamine oxidase A, have been evaluated in a multicentre placebo-controlled double-blind randomized trial in 103 in-patients suffering from unipolar major depression (DSM-III-R 296.2, 296.3) over a 42-day period after a run-in placebo period of 6 days. Pirlindole produced a significantly greater decrease than placebo in the Hamilton depression score (from day 28), the Hamilton anxiety score (from day 28) and the Montgomery-Asberg depression score (on day 42). On day 42, the Hamilton depression score was < or = 7, > or = 8 and < or = 15, or > or = 16 in 21%, 45% and 34%, respectively, in the placebo group compared to 72%, 24% and 3.4%, respectively, in the pirlindole group (P < 0.001). The differences between the two groups in terms of tolerance and safety were not statistically significant.

journal_name

Acta Psychiatr Scand

authors

De Wilde JE,Geerts S,Van Dorpe J,Bruhwyler J,Géczy J

doi

10.1111/j.1600-0447.1996.tb09881.x

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

404-10

issue

6

eissn

0001-690X

issn

1600-0447

journal_volume

94

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    doi:10.1111/j.1600-0447.1998.tb09969.x

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  • Cognitive functioning and survival in psychogeriatric patients.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03121.x

    authors: Berg S,Jeppson L

    更新日期:1991-08-01 00:00:00

  • Differences in the placebo response in duloxetine and venlafaxine trials.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,meta分析

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    authors: Breilmann J,Furukawa TA,Becker T,Koesters M

    更新日期:2018-06-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0447.2001.00357.x

    authors: Walsh MT,Dinan TG

    更新日期:2001-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2001.00372.x

    authors: Nilsson FM,Kessing LV,Bolwig TG

    更新日期:2001-11-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1984.tb02491.x

    authors: Kitamura T,Kahn A,Kumar R

    更新日期:1984-03-01 00:00:00

  • Religious psychotherapy in anxiety disorder patients.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1600-0447.1994.tb01545.x

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    更新日期:1994-07-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2011.01801.x

    authors: Kuchibhatla MN,Fillenbaum GG,Hybels CF,Blazer DG

    更新日期:2012-06-01 00:00:00

  • The Italian mental health reform nine years on.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05163.x

    authors: Crepet P

    更新日期:1988-05-01 00:00:00

  • Adjustment reactions: a long-term prospective and retrospective follow-up of former patients in a crisis intervention ward.

    abstract::The results of a 5-year follow-up study of 76 patients in a crisis intervention ward who were suffering from an adjustment reaction (brief or prolonged depressive reaction) according to ICD-9 criteria indicate a rather favorable course and outcome using standardized instruments. Only 17% developed a chronic or severe ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb01426.x

    authors: Bronisch T

    更新日期:1991-07-01 00:00:00

  • Stress, depression and left-sided psychogenic chest pain.

    abstract::Ninety men between the ages of 20 to 65 were studied to investigate the relationships between stress, depression and psychogenic pain. Three groups (the coronary heart disease (CHD) group; the left-sided psychogenic chest pain (LPCP) group; and the control group) comprising 30 patients per group, each completed the So...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03406.x

    authors: Naidoo P,Patel CJ

    更新日期:1993-07-01 00:00:00

  • Gender differences in the incidence of definite schizophrenia and atypical psychosis--focus on negative symptoms of schizophrenia.

    abstract::In a catchment area study of 101 first inceptions of schizophrenia, mania and atypical psychoses, women were significantly more likely to have atypical psychosis and men were more likely to have definite schizophrenia. Negative symptoms such as affective flattening and poverty of speech were already present in many ca...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1991.tb03182.x

    authors: Ring N,Tantam D,Montague L,Newby D,Black D,Morris J

    更新日期:1991-12-01 00:00:00

  • Improvement in verbal memory performance in depressed in-patients after treatment with electroconvulsive therapy.

    abstract:OBJECTIVE:Electroconvulsive therapy (ECT) is a highly effective and well-tolerated therapy for severe and treatment-resistant depression. Cognitive side-effects are still feared by some patients and clinicians. Importantly, cognitive impairments are among the most disabling symptoms of depression itself. METHODS:Patie...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12652

    authors: Biedermann SV,Bumb JM,Demirakca T,Ende G,Sartorius A

    更新日期:2016-12-01 00:00:00

  • The impact of availability, attraction and lethality of suicide methods on suicide rates in Germany.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03474.x

    authors: Wiedenmann A,Weyerer S

    更新日期:1993-11-01 00:00:00

  • The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: results of a controlled family study.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03372.x

    authors: Heun R,Maier W

    更新日期:1993-04-01 00:00:00

  • Understanding auditory verbal hallucinations: a systematic review of current evidence.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

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    更新日期:2016-05-01 00:00:00

  • Drug abuse as seen in the University Department of Psychiatry, Kaduna, Nigeria, in 1980-1984.

    abstract::367 new cases of drug abuse and related cases were admitted to the teaching hospital within the study period. These cases comprised approximately 11% of all new admissions during the period. 80% were between 15 and 30 years, and 76% of them were single. People in this age group tend to abuse cannabis and amphetamine m...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06234.x

    authors: Ahmed MH

    更新日期:1986-07-01 00:00:00

  • Crazy? So what! Effects of a school project on students' attitudes towards people with schizophrenia.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2003.02444.x

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02695.x

    authors: Hwu HG,Yeh EK,Chang LY,Yeh YL

    更新日期:1986-04-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

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    authors: Strejilevich SA,Martino DJ,Murru A,Teitelbaum J,Fassi G,Marengo E,Igoa A,Colom F

    更新日期:2013-09-01 00:00:00

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1600-0447.1995.tb09580.x

    authors: Lecrubier Y,Pedarriosse AM,Payan C,Schmid-Burgk W,Stabl M

    更新日期:1995-10-01 00:00:00

  • The development of the Self-Rating Inventory for Posttraumatic Stress Disorder.

    abstract::In this study a newly developed Self-rating Inventory for Posttraumatic Stress Disorder (PTSD) is presented. The instrument consists of 47 items, reflecting DSM-III-R criteria, associated features and items corresponding to the disorder of extreme stress not otherwise specified. All items are phrased in a trauma-indep...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01574.x

    authors: Hovens JE,van der Ploeg HM,Bramsen I,Klaarenbeek MT,Schreuder JN,Rivero VV

    更新日期:1994-09-01 00:00:00

  • Diagnostic validity of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review.

    abstract:OBJECTIVE:At least 50% of bipolar disorder (BD) patients have an additional diagnosis, one of the most difficult to manage being obsessive-compulsive disorder (OCD). Defining the nosology of BD-OCD comorbidity has important clinical implications, given that treatments for OCD can worsen BD outcomes. METHOD:A systemati...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/acps.12250

    authors: Amerio A,Odone A,Liapis CC,Ghaemi SN

    更新日期:2014-05-01 00:00:00

  • Severe childhood trauma and clinical and neurocognitive features in schizotypal personality disorder.

    abstract:OBJECTIVE:Literature suggests that childhood trauma increases vulnerability for schizophrenia-spectrum disorders, including schizotypal personality disorder (SPD). Yet, it remains unexplored whether childhood trauma predicts symptom load and the level of neurocognitive functioning in SPD. METHOD:We included 225 indivi...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.13032

    authors: Velikonja T,Velthorst E,McClure MM,Rutter S,Calabrese WR,Rosell D,Koenigsberg HW,Goodman M,New AS,Hazlett EA,Perez-Rodriguez MM

    更新日期:2019-07-01 00:00:00

  • Risk of psychiatric disorders, self-harm behaviour and service use associated with bariatric surgery.

    abstract:OBJECTIVE:To investigate psychiatric outcomes after bariatric surgery, including suicide, self-harm, psychiatric service use and substance misuse. METHOD:Retrospective study on a Danish nationwide register-based cohort of 22 451 patients followed for 1 029 736 person-years. Data were analysed utilizing single- and mul...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12669

    authors: Kovacs Z,Valentin JB,Nielsen RE

    更新日期:2017-02-01 00:00:00

  • Bimodal distribution of serum trypotphan level.

    abstract::Serum levels of total L-tryptophan (L-TP) were determined before and during treatment in patients suffering from endogenous depression, who were treated with L-TP, 6 g daily, and unilateral electroconvulsive therapy (ECT). The gaussian curve of initial L-TP concentrations changed into a bimodal distribution during tre...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1979.tb00260.x

    authors: d'Elia G,Lehmann J,Raotma H

    更新日期:1979-07-01 00:00:00

  • Emotional hyper-reactivity and cardiometabolic risk in remitted bipolar patients: a machine learning approach.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12901

    authors: Dargél AA,Roussel F,Volant S,Etain B,Grant R,Azorin JM,M'Bailara K,Bellivier F,Bougerol T,Kahn JP,Roux P,Aubin V,Courtet P,Leboyer M,FACE-BD Collaborators.,Kapczinski F,Henry C

    更新日期:2018-10-01 00:00:00

  • Does family history of schizophrenia influence age at onset of schizophrenia?

    abstract::The relation between age at onset of schizophrenia diagnosed using DSM-III criteria and the presence or absence of this illness among first-degree relatives was investigated in 2417 patients. The mean age at onset among those with a family history of schizophrenia was slightly and nonsignificantly earlier than that of...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb06410.x

    authors: Shimizu A,Kurachi M,Yamaguchi N,Torii H,Isaki K

    更新日期:1988-12-01 00:00:00

  • Synaesthesia and major affective disorder.

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    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1988.tb05158.x

    authors: McKane JP,Hughes AM

    更新日期:1988-04-01 00:00:00

  • Early behavioral symptoms and course of Alzheimer's disease.

    abstract:OBJECTIVE:To determine if behavioral symptoms detected at initial evaluation relate to cognitive or functional status or survival time in Alzheimer's disease (AD) patients. method: Review, in 100 cases of autopsy-proven AD, of the relationship of behavioral symptoms detected at initial evaluation to cognitive and globa...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1111/j.1600-0447.2004.00472.x

    authors: Weiner MF,Hynan LS,Bret ME,White C 3rd

    更新日期:2005-05-01 00:00:00