Changes in learning, memory, and mood during lithium treatment. Approach to a research strategy.

Abstract:

:In a double-blind study the effects of a 14-day lithium medication (dosage: 24 mval/day to 36 mval/day) were investigated. The subjects were 24 healthy male volunteers. The effect of lithium on their mood, ability to learn nouns, and memory of the words learnt was measured after 2 hours and 14 days. In spite of a relatively low mean plasma lithium level on the 14th day (0.54 +/- 0.15 mmol/l), the lithium volunteers assessed themselves after 2 weeks of treatment as significantly less relaxed, less active, less socially involved, more bored, and more tired than the placebo group. As to learning, the lithium group showed only a slight impairment of performance compared with the placebo groups. As to memory, there was a significant difference in free recall over 2 weeks: the lithium group remembered fewer words than the placebo group. Additional motivation of free recall over 2 hours was ineffective. It is discussed whether lithium changes spontaneous initial action and thereby the will to act. This could be interpreted as a change in the production of the characteristics of experience and behaviour.

journal_name

Acta Psychiatr Scand

authors

Kropf D,Müller-Oerlinghausen B

doi

10.1111/j.1600-0447.1979.tb06951.x

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

97-124

issue

1

eissn

0001-690X

issn

1600-0447

journal_volume

59

pub_type

临床试验,杂志文章
  • Electrodermal and heart-rate measurements in chronic and partially remitted schizophrenic patients.

    abstract::Electrodermal activity and heart-rate were recorded in the laboratory from partially remitted schizophrenic patients living in the community, chronic schizophrenic inpatients and normal controls. Althoug all patients had faster heart-rates, no consistent electrodermal differences between patient groups and normals wer...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1978.tb06905.x

    authors: Tarrier N,Cooke EC,Lader MH

    更新日期:1978-05-01 00:00:00

  • Psychodynamic personality profile in first-episode severe mental disorders.

    abstract:OBJECTIVE:The aim of this study was to relate measures of psychoanalytically derived personality traits to descriptive diagnosis and psychopathology in severe mental disorders. METHOD:Sixty-one consecutive first-episode patients with schizophrenia, bipolar disorder and severe major depression were interviewed. Persona...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2003.00289.x

    authors: Heikkilä J,Karlsson H,Taiminen T,Lauerma H,Ilonen T,Leinonen KM,Wallenius E,Virtanen H,Heinimaa M,Kaljonen A,Salokangas RK

    更新日期:2004-03-01 00:00:00

  • Continuity of formal thought disorder from childhood to adulthood in a high-risk sample.

    abstract::Within a longitudinal prospective study of children of schizophrenic mothers, premorbid, childhood levels of formal thought disorder correlated positively with measures of formal thought disorder obtained in adulthood. It is therefore concluded that schizophrenic symptomatology develops by gradual accretion and that s...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb06240.x

    authors: Parnas J,Schulsinger H

    更新日期:1986-09-01 00:00:00

  • Changes in negative symptoms and the risk of tardive dyskinesia: a longitudinal study. UK700 Group.

    abstract:OBJECTIVE:To examine whether the development of tardive dyskinesia (TD) is accompanied by a parallel process of worsening negative symptoms in a longitudinal study. METHOD:A sample of 708 psychotic patients were followed over a period of 2 years, using the Abnormal Involuntary Movement Scale and the Scale for the Asse...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:

    authors: van Os J,Walsh E,van Horn E,Tattan T,Bale R,Thompson SG

    更新日期:2000-04-01 00:00:00

  • Emotional hyper-reactivity and cardiometabolic risk in remitted bipolar patients: a machine learning approach.

    abstract:OBJECTIVE:Remitted bipolar disorder (BD) patients frequently present with chronic mood instability and emotional hyper-reactivity, associated with poor psychosocial functioning and low-grade inflammation. We investigated emotional hyper-reactivity as a dimension for characterization of remitted BD patients, and clinica...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12901

    authors: Dargél AA,Roussel F,Volant S,Etain B,Grant R,Azorin JM,M'Bailara K,Bellivier F,Bougerol T,Kahn JP,Roux P,Aubin V,Courtet P,Leboyer M,FACE-BD Collaborators.,Kapczinski F,Henry C

    更新日期:2018-10-01 00:00:00

  • Service utilization and costs of first-onset schizophrenia in two widely differing health service areas in North-East Spain. PSICOST Group.

    abstract:OBJECTIVE:The aim of the study was to analyse the cost-incidence of schizophrenia in two areas with widely differing health service systems. METHOD:The costs of patients with schizophrenia in the 3 years after the first service contact were evaluated (i) in an area (A) with fully developed mental health community prog...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1999.tb10876.x

    authors: Salvador-Carulla L,Haro JM,Cabasés J,Madoz V,Sacristán JA,Vázquez-Barquero JL

    更新日期:1999-11-01 00:00:00

  • Serotonin and amino acid content in platelets of autistic children.

    abstract::The platelet levels of serotonin and the amino acids aspartic acid, glutamine, glutamic acid and gamma-aminobutyric acid were measured in 18 drug-free autistic (DSM-III criteria) and 14 age-matched healthy children. Serotonin was significantly increased while the amino acids aspartic acid, glutamine, glutamic acid and...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1993.tb03378.x

    authors: Rolf LH,Haarmann FY,Grotemeyer KH,Kehrer H

    更新日期:1993-05-01 00:00:00

  • Polyneuropathy caused by chlorprothixene.

    abstract::Seven chronic psychiatric patients developed signs of polyneuropathy mainly in the lower limbs after receiving chlorprothixene (500-1800 mg/d) from 3 to more than 24 months. The most prominent electroneuromyographic findings were decreased or not measurable motor conduction velocities of the peroneal nerves. Electromy...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb08604.x

    authors: Luisto M

    更新日期:1992-03-01 00:00:00

  • Electrodermal activity in antidepressant medicated and unmedicated depressive patients and in matched healthy subjects.

    abstract::A group of 59 depressive in- and outpatients displayed statistically significantly subnormal electrodermal activity (EDA) according to the skin conductance level, the skin conductance response magnitude, the skin conductance response rate, and the index of nonresponding during neutral tone stimulation, compared to 59 ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1987.tb02940.x

    authors: Thorell LH,Kjellman BF,d'Elia G

    更新日期:1987-12-01 00:00:00

  • A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.

    abstract::The clinical effect of a sustained release preparation of amitriptyline has been compared with that of conventional amitriptyline tablets in a double-blind cross-over study with 24 patients suffering from endogenous depression. The sustained release preparation was given in a single evening dose (9 p.m.) of two thirds...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1978.tb06911.x

    authors: Liisberg P,Mose H,Amdisen A,Jørgensen A,Petersen HE

    更新日期:1978-05-01 00:00:00

  • Suicidal ideation and parasuicide in the Finnish general population.

    abstract::In a sample of the Finnish general population (n=4868), 2.4% of women and 2.3 % of men reported having thought about suicide during the preceding 12 months. The prevalence of parasuicide was correspondingly 0.9% in women and 1.1% in men, higher figures than have previously been found or estimated. Most suicidal indivi...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1998.tb10037.x

    authors: Hintikka J,Viinamäki H,Tanskanen A,Kontula O,Koskela K

    更新日期:1998-07-01 00:00:00

  • Gender differences in unipolar depression: an update of epidemiological findings and possible explanations.

    abstract:OBJECTIVE:To give an update on epidemiological findings on sex differences in the prevalence of unipolar depression and putative risk factors. MATERIAL AND METHODS:Systematic review of the literature. RESULTS:Recent epidemiological research yields additional evidence for a female preponderance in unipolar depression,...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章,评审

    doi:10.1034/j.1600-0447.2003.00204.x

    authors: Kuehner C

    更新日期:2003-09-01 00:00:00

  • Linkage between X-chromosome markers and manic-depressive illness. Two Sardinian pedigrees.

    abstract::Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were foun...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1984.tb01210.x

    authors: Del Zompo M,Bocchetta A,Goldin LR,Corsini GU

    更新日期:1984-09-01 00:00:00

  • Diagnosis change, lithium use and admissions for mania in Edinburgh.

    abstract::Admissions for mania have risen significantly in Edinburgh since 1970. Differencing was used to remove time trends; this showed that the rise was not accounted for by diagnosis change (from schizophrenia or personality disorder) or by lithium prescription. The contribution of non-specific factors such as admission pol...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb03002.x

    authors: Mander AJ

    更新日期:1989-11-01 00:00:00

  • Menstrual cycle and profiles of suicidal behaviour.

    abstract::The first (or menstrual) and fourth (or premenstrual) week of the menstrual cycle may be associated with many suicide attempts in women. The study sample included 113 Spanish women who attempted suicide and contacted an emergency service. Inclusion criteria were as follows: fertility; regular menstrual cycles; lack of...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1998.tb09959.x

    authors: Baca-García E,Sánchez-González A,González Diaz-Corralero P,González García I,de Leon J

    更新日期:1998-01-01 00:00:00

  • Services for people at high risk improve outcomes in patients with first episode psychosis.

    abstract:OBJECTIVE:About one-third of patients referred to services for people at high risk for psychosis may have already developed a first episode of psychosis (FEP). We compared clinical outcomes in FEP patients who presented to either high risk or conventional mental health services. METHOD:Retrospective study comparing du...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12480

    authors: Fusar-Poli P,Díaz-Caneja CM,Patel R,Valmaggia L,Byrne M,Garety P,Shetty H,Broadbent M,Stewart R,McGuire P

    更新日期:2016-01-01 00:00:00

  • Clinical diagnoses in young offspring from eastern Québec multigenerational families densely affected by schizophrenia or bipolar disorder.

    abstract:OBJECTIVE:The follow-up since 1989 of a large sample of multigenerational families of eastern Québec that are densely affected by schizophrenia (SZ) or bipolar disorder (BP) has permitted to look at the rates of DSM diagnoses in the young offspring of a SZ parent (HRSZ) and of a BP parent (HRBP) who had an extremely lo...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.2007.01125.x

    authors: Maziade M,Gingras N,Rouleau N,Poulin S,Jomphe V,Paradis ME,Mérette C,Roy MA

    更新日期:2008-02-01 00:00:00

  • A case of hypophyseal prolactinoma with treatable delusions of dermatozoiasis.

    abstract::The case of an autopsied patient with hypophyseal prolactinoma and dermatozoic delusions is reported, and the mechanism of onset of this special form of delusion is discussed from the neuroendocrinological view point, including response to medications, and neuropathological and pituitary hormonal studies. The subject ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1985.tb02641.x

    authors: Takeda M,Tanino S,Nishinuma K,Matsubayashi T,Yamashita S,Nishimura T

    更新日期:1985-11-01 00:00:00

  • Validity of the ICD-9 schizophrenia classification. A blind family history study.

    abstract::Within the framework of the multifactorial-polygenic model of inheritance, multiple threshold strategy was applied to a large set of pedigree data to examine the clinico-genetical position of some subtypes within the ICD-9 classification of schizophrenic psychoses. It appeared highly probable that the ICD-9 subtypes e...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1983.tb07009.x

    authors: Ungvári G

    更新日期:1983-10-01 00:00:00

  • Hypothalamic-pituitary-adrenocortical function in mixed and pure mania.

    abstract::There is little information about hypothalamic-pituitary-adrenocortical (HPA) axis function in mania, particularly in mixed states. We therefore investigated HPA function and its relationship to clinical state in 19 hospitalized manic patients meeting Schedule for Affective Disorders and Schizophrenia - Research Diagn...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1992.tb01468.x

    authors: Swann AC,Stokes PE,Casper R,Secunda SK,Bowden CL,Berman N,Katz MM,Robins E

    更新日期:1992-04-01 00:00:00

  • Hopelessness and first-episode psychosis: a longitudinal study.

    abstract::Hopelessness has not been adequately studied in first-episode psychotic patients, although it is already present at the early stages, especially in schizophrenic patients. We have studied 96 neuroleptic-naive psychotic patients (49 schizophrenic patients and 47 other non-affective psychotic patients) over a period of ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1997.tb09900.x

    authors: Aguilar EJ,Haas G,Manzanera FJ,Hernández J,Gracia R,Rodado MJ,Keshavan MS

    更新日期:1997-07-01 00:00:00

  • Schizophrenia: a 13-year follow-up. Diagnostic and psychopathological aspects.

    abstract::In Denmark about 11-12 per 100,000 population are diagnosed as schizophrenics for the first time each year. Less than half of these receive this diagnosis at first admission and therefore only 5-6 per 100,000 are included in the official schizophrenia incidence figures. In a cohort (n = 53), predictors for diagnosis o...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1989.tb10275.x

    authors: Munk-Jørgensen P,Mortensen PB

    更新日期:1989-04-01 00:00:00

  • Subthreshold and threshold attention deficit hyperactivity disorder symptoms in childhood: psychosocial outcomes in adolescence in boys and girls.

    abstract:OBJECTIVE:To examine the association between different levels of childhood attention deficit hyperactivity disorder (ADHD) symptoms and sex differences in psychosocial outcomes during adolescence. METHOD:Swedish children (n = 4635) were screened for neuropsychiatric symptoms at age 9 or 12. ADHD symptoms were divided ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/acps.12655

    authors: Norén Selinus E,Molero Y,Lichtenstein P,Anckarsäter H,Lundström S,Bottai M,Hellner Gumpert C

    更新日期:2016-12-01 00:00:00

  • An experimental evaluation of the euphoric properties of antiparkinson drugs on psychotic patients.

    abstract::Seven psychotic inpatients (two women and five men) aged between 18 and 74 years, treated with neuroleptic and antiparkinson drugs, participated in a double-blind study with 1/3 DDD (Defined Daily Dose) of procyclidine, orphenadrine, or trihexyphenidyl hydrochloride against placebo. Euphoric effects were scored on a s...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0447.1986.tb06277.x

    authors: Vågen R,Götestam KG

    更新日期:1986-11-01 00:00:00

  • P300 and smooth eye pursuit: concordance of abnormalities and relation to clinical features in DSM-III schizophrenia.

    abstract::Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group dif...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1990.tb01385.x

    authors: Ebmeier KP,Potter DD,Cochrane RH,Mackenzie AR,MacAllister H,Besson JA,Salzen EA

    更新日期:1990-10-01 00:00:00

  • Neuroleptic dose and schizophrenic symptoms. A survey of prescribing practices.

    abstract::A study was conducted to survey the prescribing practices of neuroleptic doses in 100 consecutively hospitalized DSM-III-R schizophrenic patients. The relationship between doses and clinical and symptomatological variables was subsequently analyzed. Patients were evaluated through the Positive and Negative Syndrome Sc...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1994.tb01606.x

    authors: Peralta V,Cuesta MJ,Caro F,Martinez-Larrea A

    更新日期:1994-11-01 00:00:00

  • Clinical aspects of hysteria.

    abstract::This is a clinical study of 80 patients, diagnosed as suffering from hysteria, who attended the psychiatric clinic in Khartoum Hospital over a period of 3 years. The incidence of hysteria was 10%, the female-male ratio 15:1, and young age-groups predominate. 60% were essentially of normal personality. The clinical pic...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1986.tb02742.x

    authors: Hafeiz HB

    更新日期:1986-06-01 00:00:00

  • Mortality in alcoholics related to clinical state at first admission. A study of 537 deaths.

    abstract::The Department of Psychiatry, University Hospital, Lund, is in possession of systematic clinical ratings from 1949 to 1969 based on a multi-dimensional diagnostic schedule. All 1312 first-admitted patients (120 women) from the county who were rated as "chronic alcohol intoxication" were followed up until 31 December, ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1984.tb01228.x

    authors: Berglund M

    更新日期:1984-11-01 00:00:00

  • Aging of schizophrenic patients as seen through the Rorschach test.

    abstract::The authors have repeated, on the average 29.7 years later, Rorschach test in 11 schizophrenic men and 19 schizophrenic women. This work was carried out in the course of a follow-up study of schizophrenics more than 65 years of age. Analysis of the records showed that the only differences between the first and second ...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0447.1976.tb00071.x

    authors: Müller C,Le-Dinh T

    更新日期:1976-03-01 00:00:00

  • Increased risk of developing Parkinson's disease for patients with major affective disorder: a register study.

    abstract:OBJECTIVE:To investigate whether patients with a diagnosis of affective disorder are at an increased risk of developing Parkinson's disease compared with medically ill control groups. METHOD:By linkage of public hospital registers from 1977 to 1993, three study cohorts were identified: patients with affective disorder...

    journal_title:Acta psychiatrica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0447.2001.00372.x

    authors: Nilsson FM,Kessing LV,Bolwig TG

    更新日期:2001-11-01 00:00:00