Prevalence of Toxoplasma infection in first-episode schizophrenia and comparison between Toxoplasma-seropositive and Toxoplasma-seronegative schizophrenia.

Abstract:

OBJECTIVE:To compare the prevalence of Toxoplasma infection between the first-episode schizophrenia and the controls and to compare the clinical features between the Toxoplasma-seronegative and Toxoplasma-seropositive patients with schizophrenia. METHOD:The rate of serum reactivity to Toxoplasma in 600 schizophrenia, 600 affective disorders, and 400 controls was investigated. The clinical symptoms of the schizophrenia patients were scored and compared. RESULTS:The rate of IgG antibody, not IgM in the schizophrenia patients, was higher than the control groups, and the odds ratio of schizophrenia associated with IgG antibody was 2.22-5.12. The affective disorders did not differ in the rate of IgG or IgM antibody from the normal or the physical disease control. The seropositive schizophrenia patients had higher scores on the positive subscale and three components of Positive and Negative Symptoms Scale than the seronegative patients. CONCLUSION:This study lent further weight to the hypothesis that exposure to Toxoplasma may be a risk factor for schizophrenia.

journal_name

Acta Psychiatr Scand

authors

Wang HL,Wang GH,Li QY,Shu C,Jiang MS,Guo Y

doi

10.1111/j.1600-0447.2006.00780.x

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

40-8

issue

1

eissn

0001-690X

issn

1600-0447

pii

ACP780

journal_volume

114

pub_type

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