当前位置： SCI文献检索 > ONCOLOGY NURSING FORUM期刊下所有文献 > An evaluation of the permeability of chemotherapy gloves to three cancer chemotherapy drugs.

An evaluation of the permeability of chemotherapy gloves to three cancer chemotherapy drugs.

Abstract：

PURPOSE/OBJECTIVES:To evaluate the permeability of chemotherapy gloves when using carmustine (BCNU), etoposide, and paclitaxel, which were selected based on their reported toxicity and unique solvent systems. SAMPLE:Thirteen brands of chemotherapy gloves and one brand of examination glove. Of the 14 glove types tested, 11 were made of latex, and 3 were made of nitrile. METHODS:Ten samples of each type of glove were evaluated using rigorous laboratory test conditions usually not encountered in normal usage. The thickness of the gloves was measured using a digital caliper. The glove material was secured over glass vials containing the drug solution and inverted in plastic cell wells containing a filter paper disc. After a two-hour exposure time, the filter paper discs were removed and analyzed for the presence of the drug. MAIN RESEARCH VARIABLES:Permeability (i.e., greater than or equal to 1% of the total amount of drug passing through the glove material.) FINDINGS:All 14 types of gloves tested were impermeable to BCNU at two hours of exposure. Only two gloves, the Ansell Perry EP glove and the U.S. Clinical Chemo Bloc T glove, were impermeable to all three drugs. The remaining 12 gloves all demonstrated some level of permeation with etoposide at two hours, although 9 of the gloves had only 1 of 10 samples that were permeable. In all cases, percent of permeation was less than 2% of the amount of the drug in the test solution. Thirteen gloves tested for paclitaxel permeability were impermeable at the two-hour time period. CONCLUSIONS:The results of this study indicate that most of the chemotherapy gloves on the market are either impermeable or minimally permeable to these three chemotherapy drugs. IMPLICATIONS FOR NURSING PRACTICE:Because gloves are universally recognized as a means of personal protection when handling cancer chemotherapy drugs, selection of a glove that is impermeable would be an obvious choice for healthcare workers. Although the present study was a static, laboratory-based study that did not duplicate actual work practice conditions. It should offer some guidance in the selection of glove types when handling chemotherapy drugs.

journal_name

Oncol Nurs Forum

journal_title

Oncology nursing forum

authors

Singleton LC,Connor TH

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

1491-6

issue

eissn

0190-535X

issn

1538-0688

journal_volume

pub_type

杂志文章

在线工具

An evaluation of the permeability of chemotherapy gloves to three cancer chemotherapy drugs.