Abstract:
PURPOSE:To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. METHODS:Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, placebo-controlled trial. To achieve steady-state tissue levels, either placebo or diclofenac was orally administered two times a day for 27 consecutive days. A strenuous 20-min stepping exercise program, about which the subjects were unfamiliar, was conducted on day 15. Creatine kinase (CK) activities were measured immediately before the exercise session and on days 16, 18, and 27. Vastus lateralis muscle samples were obtained immediately before exercise and on day 27 for subsequent histological characterization of muscle inflammation. RESULTS:The preexercise muscle samples revealed no difference in muscle damage between the two groups. However, the postexercise muscle samples showed that the diclofenac-treated group demonstrated less muscle tissue damage than placebo-treated subjects (P = 0.002). The administration of diclofenac also resulted in a significant lowering of post-/pre-exercise CK ratios on days 18 (P = 0.03) and 27 (P = 0.02) compared with the placebo group, an indirect finding that supports the possibility of diclofenac reducing exercise-induced muscle damage. CONCLUSION:These findings demonstrate preadministration of diclofenac (in accordance with tissue half-life pharmacokinetics) significantly reduces quantitative indices of exercise-induced skeletal muscle damage in human muscle.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
O'Grady M,Hackney AC,Schneider K,Bossen E,Steinberg K,Douglas JM Jr,Murray WJ,Watkins WDdoi
10.1097/00005768-200007000-00001subject
Has Abstractpub_date
2000-07-01 00:00:00pages
1191-6issue
7eissn
0195-9131issn
1530-0315journal_volume
32pub_type
临床试验,杂志文章,随机对照试验abstract:INTRODUCTION:It is well established that regular physical activity (PA) contributes to lower levels of morbidity and mortality. However, little is known about the stability of very young children's PA habits across seasons and years. The aims of this study were to 1) examine the influence of season and increasing age o...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182464db5
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000180359.98241.a2
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200011000-00013
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abstract::A biomechanical model of the ankle joint was developed and was used to predict the forces at the ankle during the stance phase of running. Measurements from five cadavers were averaged to obtain insertion points and directions of pull of equivalent tendons with respect to the assumed center of the ankle joint. A minim...
journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
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abstract:BACKGROUND:Extracellular vesicles (EV) are purported to mediate type 2 diabetes and CVD risk and development. Physical activity and a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would reduce EV compared with continuous (CONT) exercise in adults with ...
journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200110000-00009
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200111000-00004
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
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更新日期:1985-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
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