Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle.

Abstract:

PURPOSE:To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. METHODS:Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, placebo-controlled trial. To achieve steady-state tissue levels, either placebo or diclofenac was orally administered two times a day for 27 consecutive days. A strenuous 20-min stepping exercise program, about which the subjects were unfamiliar, was conducted on day 15. Creatine kinase (CK) activities were measured immediately before the exercise session and on days 16, 18, and 27. Vastus lateralis muscle samples were obtained immediately before exercise and on day 27 for subsequent histological characterization of muscle inflammation. RESULTS:The preexercise muscle samples revealed no difference in muscle damage between the two groups. However, the postexercise muscle samples showed that the diclofenac-treated group demonstrated less muscle tissue damage than placebo-treated subjects (P = 0.002). The administration of diclofenac also resulted in a significant lowering of post-/pre-exercise CK ratios on days 18 (P = 0.03) and 27 (P = 0.02) compared with the placebo group, an indirect finding that supports the possibility of diclofenac reducing exercise-induced muscle damage. CONCLUSION:These findings demonstrate preadministration of diclofenac (in accordance with tissue half-life pharmacokinetics) significantly reduces quantitative indices of exercise-induced skeletal muscle damage in human muscle.

journal_name

Med Sci Sports Exerc

authors

O'Grady M,Hackney AC,Schneider K,Bossen E,Steinberg K,Douglas JM Jr,Murray WJ,Watkins WD

doi

10.1097/00005768-200007000-00001

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

1191-6

issue

7

eissn

0195-9131

issn

1530-0315

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
  • Seasonal and annual variation in young children's physical activity.

    abstract:INTRODUCTION:It is well established that regular physical activity (PA) contributes to lower levels of morbidity and mortality. However, little is known about the stability of very young children's PA habits across seasons and years. The aims of this study were to 1) examine the influence of season and increasing age o...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3182464db5

    authors: McKee DP,Murtagh EM,Boreham CA,Nevill AM,Murphy MH

    更新日期:2012-07-01 00:00:00

  • RPE association with lactate and heart rate during high-intensity interval cycling.

    abstract:PURPOSE:Physiological and perceptual measures during interval exercise are not well understood. The current study therefore examined the correspondence between RPE, HR, and blood lactate concentration ([La]) during interval cycling. METHODS:VO2peak and the 4.0 mmol x L(-1) lactate threshold were determined. In session...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000180359.98241.a2

    authors: Green JM,McLester JR,Crews TR,Wickwire PJ,Pritchett RC,Lomax RG

    更新日期:2006-01-01 00:00:00

  • Serum IGF-I is higher in gymnasts than runners and predicts bone and lean mass.

    abstract:INTRODUCTION:We examined the relationships between insulin-like growth factor I (IGF-I), its binding protein (IGFBP-3), body composition, and bone mineral density (BMD) in collegiate runners (N = 13), gymnasts (N = 10), and noncompetitive women (N = 10). METHODS:Subjects were evaluated by dual-energy x-ray absorptiome...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200011000-00013

    authors: Snow CM,Rosen CJ,Robinson TL

    更新日期:2000-11-01 00:00:00

  • Forces predicted at the ankle during running.

    abstract::A biomechanical model of the ankle joint was developed and was used to predict the forces at the ankle during the stance phase of running. Measurements from five cadavers were averaged to obtain insertion points and directions of pull of equivalent tendons with respect to the assumed center of the ankle joint. A minim...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/00005768-198204000-00010

    authors: Burdett RG

    更新日期:1982-01-01 00:00:00

  • Critical Velocity during Intermittent Running with Changes of Direction.

    abstract:PURPOSE:We tested the hypothesis that critical velocity (CV) during intermittent running with changes of direction is reliably and accurately identified from a simple shuttle field test. We also tested the hypothesis that CV during intermittent running with changes of direction running is not equivalent to continuous l...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001774

    authors: Kirby BS,Bradley EM,Wilkins BW

    更新日期:2019-02-01 00:00:00

  • Energy expenditure in adolescents during low intensity, leisure activities.

    abstract::We sought to determine how a stationary activity such as playing a stringed instrument may affect energy expenditure (EE) in adolescents. Using automated indirect calorimetry, we measured EE in eight adolescents (1 male, 7 females, 14.2 +/- 2.1 yr) while they each performed the following activities: watching televisio...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Horswill CA,Kien CL,Zipf WB

    更新日期:1995-09-01 00:00:00

  • Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.

    abstract:BACKGROUND:Extracellular vesicles (EV) are purported to mediate type 2 diabetes and CVD risk and development. Physical activity and a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would reduce EV compared with continuous (CONT) exercise in adults with ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000002185

    authors: Eichner NZM,Gilbertson NM,Heiston EM,Musante L,LA Salvia S,Weltman A,Erdbrugger U,Malin SK

    更新日期:2020-03-01 00:00:00

  • Effect of beta 1-receptor blockade on coronary resistance in partially trained dogs.

    abstract::Selective beta 1-receptor blockade with atenolol (1 mg X kg-1, i.v.) was used to determine the effect of partial exercise training on diastolic coronary resistance (DCR) during sub-maximal exercise. Seven conscious dogs were studied in the untrained (UT) and partially trained (PT) conditions. The conditioning regime c...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Liang IY,Stone HL,Gwirtz PA

    更新日期:1987-08-01 00:00:00

  • Dose effects of oral bovine colostrum on physical work capacity in cyclists.

    abstract:PURPOSE:There is interest in the potential long-term use of dietary supplementation with bovine colostrum to enhance exercise performance. The purpose of the present study was to determine the dose effects of bovine colostrum on cycling performance. METHODS:Forty-two competitive cyclists were randomly divided into thr...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005768-200207000-00020

    authors: Coombes JS,Conacher M,Austen SK,Marshall PA

    更新日期:2002-07-01 00:00:00

  • Vigorous exercise and diabetic, hypertensive, and hypercholesterolemia medication use.

    abstract:PURPOSE:The prevalences of diabetes, hypertension, and high cholesterol all decrease with increased levels of physical activity and cardiorespiratory fitness. Whether these reductions extend beyond contemporary guideline activity levels and whether fitness affects medication use independent of activity, remains unclear...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e318145b337

    authors: Williams PT,Franklin B

    更新日期:2007-11-01 00:00:00

  • NK cell response to physical activity: possible mechanisms of action.

    abstract::Natural killer (NK) cells are highly influenced by physical exercise. The possible important mechanisms behind exercise-induced changes in NK cell function are cytokines, hyperthermia, and stress hormones, including catecholamines, growth hormone, cortisol, and beta-endorphins. Infusion studies mimicking stress hormon...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1249/00005768-199402000-00003

    authors: Pedersen BK,Ullum H

    更新日期:1994-02-01 00:00:00

  • Aerodynamic drag modeling of alpine skiers performing giant slalom turns.

    abstract:PURPOSE:Aerodynamic drag plays an important role in performance for athletes practicing sports that involve high-velocity motions. In giant slalom, the skier is continuously changing his/her body posture, and this affects the energy dissipated in aerodynamic drag. It is therefore important to quantify this energy to un...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3182443315

    authors: Meyer F,Le Pelley D,Borrani F

    更新日期:2012-06-01 00:00:00

  • Skeletal response to resistance and impact training in prostate cancer survivors.

    abstract:INTRODUCTION:Androgen deprivation therapy (ADT) is associated with significant bone loss and an increase in fracture risk among prostate cancer survivors (PCS). We investigated whether impact + resistance training could stop ADT-related declines in bone mineral density (BMD) among PCS on ADT. METHODS:We randomized 51 ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0000000000000265

    authors: Winters-Stone KM,Dobek JC,Bennett JA,Maddalozzo GF,Ryan CW,Beer TM

    更新日期:2014-08-01 00:00:00

  • Influence of delivery mode on the urinary excretion of nandrolone metabolites.

    abstract:INTRODUCTION:This study examined the influence of a supplement matrix on the excretion pattern of nandrolone metabolites in response to ingestion of a trace amount of 19-norandrostenedione. METHODS:Ten male and nine female volunteers (mean ± SD: age = 26 ± 3 yr, height = 1.71 ± 0.09 m, body mass = 70.9 ± 13.2 kg) were...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0b013e3181bf94d6

    authors: Watson P,Houghton E,Grace PB,Judkins C,Dunster PM,Maughan RJ

    更新日期:2010-04-01 00:00:00

  • Effects of different visual stimuli on postures and knee moments during sidestepping.

    abstract:PURPOSE:Evasive sidestepping during sports commonly results in noncontact anterior cruciate ligament injuries. Sidestepping in response to different simple visual stimuli has been studied previously but never investigated using quasi-game-realistic visual conditions. We compared the biomechanics of high-level and low-l...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318290c28a

    authors: Lee MJ,Lloyd DG,Lay BS,Bourke PD,Alderson JA

    更新日期:2013-09-01 00:00:00

  • Comparison and cross-validation of cycle ergometry estimates of VO2max.

    abstract::The purpose of this study was to examine the accuracy and quality of a series of cycle ergometry tests used to estimate maximal aerobic capacity (VO2max). One-hundred nine males and 71 females participated in five tests: a maximal exercise test on the treadmill, three Air Force Cycle Ergometry Tests (AF1, AF2, AF3), a...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-199711000-00019

    authors: Lockwood PA,Yoder JE,Deuster PA

    更新日期:1997-11-01 00:00:00

  • Creatine supplementation during resistance training in college football athletes.

    abstract:PURPOSE:This investigation assessed the effects of a 9-wk regimen of creatine monohydrate (Cr x H2O) supplementation coupled with resistance training on body composition and neuromuscular performance in NCAA Division I football athletes. METHODS:Twenty-five subjects were randomly assigned in a double-blind, randomized...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005768-200110000-00009

    authors: Bemben MG,Bemben DA,Loftiss DD,Knehans AW

    更新日期:2001-10-01 00:00:00

  • No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue.

    abstract::Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that t...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1249/MSS.0000000000001052

    authors: Kent JA,Ørtenblad N,Hogan MC,Poole DC,Musch TI

    更新日期:2016-11-01 00:00:00

  • Lifestyle risk factors for osteoporosis in Asian and Caucasian girls.

    abstract:PURPOSE:We investigated ethnic differences in areal bone mineral density (aBMD; g x cm(-2)) and its determinants at two levels of maturity in Asian- and Caucasian-Canadian girls. METHODS:Participants were 131 Asian (26 Tanner breast stage I (aTI) and 30 Tanner II (aTII)), and Caucasian (30 Tanner I (cTI) and 45 Tanner...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200111000-00004

    authors: Mackelvie KJ,McKay HA,Khan KM,Crocker PR

    更新日期:2001-11-01 00:00:00

  • Reduced risk of incident kidney cancer from walking and running.

    abstract:PURPOSE:This study aimed to test whether incident kidney cancer risk is associated with exercise energy expenditure (i.e., metabolic equivalents, 1 MET) when calculated from distance walked or run. METHODS:Hazard ratios (HR) and 95% confidence intervals (95% CI) from Cox proportional hazard analyses of self-reported p...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3182a4e89c

    authors: Williams PT

    更新日期:2014-02-01 00:00:00

  • Aerobic response to endurance training in prepubescent children: a critical analysis.

    abstract::Children and adolescents possess higher weight-related maximum oxygen consumption (VO2max) levels than older individuals. The capacity of prepubescent children to improve aerobic fitness with endurance training is controversial, and reported data have provided conflicting evidence. In the adult, physical activity of c...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Rowland TW

    更新日期:1985-10-01 00:00:00

  • Cleveland Clinic Postural Stability Index Norms for the Balance Error Scoring System.

    abstract:INTRODUCTION:Despite the widespread utilization of the Balance Error Scoring System (BESS) in the evaluation of concussion, it has been criticized for its error-based scoring that is susceptible to floor and ceiling effects and substantial inter-rater variability. A biomechanical outcome, Cleveland Clinic Postural Stab...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001660

    authors: Linder SM,Ozinga SJ,Koop MM,Dey T,Figler R,Cruickshank J,Alberts JL

    更新日期:2018-10-01 00:00:00

  • Step-Based Physical Activity Metrics and Cardiometabolic Risk: NHANES 2005-2006.

    abstract:PURPOSE:This study aimed to catalog the relationships between step-based accelerometer metrics indicative of physical activity volume (steps per day, adjusted to a pedometer scale), intensity (mean steps per minute from the highest, not necessarily consecutive, minutes in a day; peak 30-min cadence), and sedentary beha...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001100

    authors: Tudor-Locke C,Schuna JM Jr,Han HO,Aguiar EJ,Green MA,Busa MA,Larrivee S,Johnson WD

    更新日期:2017-02-01 00:00:00

  • Marathon running leads to partial exhaustion of ROS-generating capacity in leukocytes.

    abstract:PURPOSE:The aim of the present study was to investigate the changes occurring in leukocyte levels of reactive oxygen species (ROS) and total blood plasma antioxidant capacity (TAS) as a result of a marathon/half-marathon race. METHODS:Fourteen men participating in the Oslo Marathon 2000 and 8 women and 8 men participa...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.MSS.0000106168.12113.95

    authors: Nielsen HG,Hagberg IA,Lyberg T

    更新日期:2004-01-01 00:00:00

  • Heart rate variability during recovery from a Wingate test in adolescent males.

    abstract:PURPOSE:To evaluate the effect of maturity status on the autonomic nervous system at rest and recovery after short-term, high-intensity exercise in adolescents. METHODS:A biological maturity age was estimated in 27 males by calculating the years from peak height velocity (PHV) using a multiple regression equation. Sub...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000218126.46242.2e

    authors: Goulopoulou S,Heffernan KS,Fernhall B,Yates G,Baxter-Jones AD,Unnithan VB

    更新日期:2006-05-01 00:00:00

  • Effect of BMI on pedometers in early adolescents under free-living conditions.

    abstract:PURPOSE:Pedometers may provide valuable information regarding the ambulatory patterns of adolescents, but the effects of body mass index (BMI) on pedometer accuracy in this population are unknown.The purpose of this study was twofold: 1) to determine whether the New Lifestyles NL-2000 (NL) and the Digi-Walker SW-200 (D...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3182746aa5

    authors: Tyo BM,Bassett DR Jr,Coe DP,Feito Y,Thompson DL

    更新日期:2013-03-01 00:00:00

  • Contrasting influences of age and sex on muscle fatigue.

    abstract:PURPOSE:Greater resistance to muscle fatigue has been observed in women versus men and in older versus young individuals. As suggested mechanisms for these differences include task intensity and duty cycle, the purpose of this study was to evaluate fatigue in healthy young and older men and women during maximum-effort ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e31815bbb93

    authors: Russ DW,Towse TF,Wigmore DM,Lanza IR,Kent-Braun JA

    更新日期:2008-02-01 00:00:00

  • Upper limit for intestinal absorption of a dilute glucose solution in men at rest.

    abstract::We studied gastric and intestinal function by gastric intubation/intestinal perfusion in six healthy male volunteers to evaluate optimal use of a 6% glucose-electrolyte (GES) solution. Gastric volume, residual volume, emptying rate, and secretion were measured for an initial 763 +/- 19 ml gastric load of GES and at th...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-199704000-00009

    authors: Duchman SM,Ryan AJ,Schedl HP,Summers RW,Bleiler TL,Gisolfi CV

    更新日期:1997-04-01 00:00:00

  • Effect of ambient temperature on cardiovascular drift and maximal oxygen uptake.

    abstract:PURPOSE:This study tested the hypothesis that the magnitude of cardiovascular (CV) drift and decrease in maximal oxygen uptake (V[spacing dot above]O2max) would be greater at 35 degrees C than at 22 degrees C. METHODS:The increase in HR and decrease in stroke volume (SV) between 15 and 45 min of cycling at 59.2 +/- 1....

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181666ed7

    authors: Lafrenz AJ,Wingo JE,Ganio MS,Cureton KJ

    更新日期:2008-06-01 00:00:00

  • Effects of high altitude on substrate use and metabolic economy: cause and effect?

    abstract::In a variety of experimental models, hypoxia causes a shift in substrate use to favor increased dependence on glucose. One explanation for this phenomenon is a selective advantage derived from the increased metabolic economy (more ATP derived per unit oxygen consumed) that results when glucose is oxidized rather than ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181729dd3

    authors: Braun B

    更新日期:2008-08-01 00:00:00