Effects of high altitude on substrate use and metabolic economy: cause and effect?

Abstract:

:In a variety of experimental models, hypoxia causes a shift in substrate use to favor increased dependence on glucose. One explanation for this phenomenon is a selective advantage derived from the increased metabolic economy (more ATP derived per unit oxygen consumed) that results when glucose is oxidized rather than lipid. In support of this hypothesis, after acclimatization to hypoxia, lower oxygen consumption at a given submaximal workload has often been reported. However, evidence from several experimental models is inconsistent with the idea that the increase in glucose use is causally related to greater metabolic economy.

journal_name

Med Sci Sports Exerc

authors

Braun B

doi

10.1249/MSS.0b013e3181729dd3

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

1495-500

issue

8

eissn

0195-9131

issn

1530-0315

journal_volume

40

pub_type

杂志文章
  • Adiposity, activity, fitness, and C-reactive protein in children.

    abstract:PURPOSE:The purpose of this study was to examine the relative association of physical activity, cardiorespiratory fitness (CRF), and adiposity with C-reactive protein (CRP) in prepubescent children. METHODS:Forty-five prepubescent children (age = 9.4 ± 1.6 yr; 26 boys) were assessed for adiposity (percent fat) via dua...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181e0355e

    authors: Parrett AL,Valentine RJ,Arngrímsson SA,Castelli DM,Evans EM

    更新日期:2010-11-01 00:00:00

  • Carbohydrate-electrolyte replacement improves distance running performance in the heat.

    abstract::The effects of a 7% carbohydrate-electrolyte drink (CE) and an artificially sweetened placebo (P) on performance and physiological function were compared during a 40-km run in the heat. Eight highly trained male runners completed two runs on a measured outdoor course. The first 35 km of each run was performed at self-...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章

    doi:

    authors: Millard-Stafford ML,Sparling PB,Rosskopf LB,DiCarlo LJ

    更新日期:1992-08-01 00:00:00

  • Associations of Muscle Mass and Strength with All-Cause Mortality among US Older Adults.

    abstract:INTRODUCTION:Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. METHODS:We aimed to prospectively examine individual and joint associations ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001448

    authors: Li R,Xia J,Zhang XI,Gathirua-Mwangi WG,Guo J,Li Y,McKenzie S,Song Y

    更新日期:2018-03-01 00:00:00

  • Evidence for a greater elevation in vascular shear stress after morning exercise.

    abstract:INTRODUCTION:The vascular endothelium plays an important role in the maintenance of vascular health and the modulation of vascular tone and blood pressure. Recently, it has been demonstrated that blood pressure reactivity to physical activity is greater in the morning, and possibly, diurnal variation in vascular functi...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318195109c

    authors: Jones H,Green DJ,George KP,Black MA,Atkinson G

    更新日期:2009-06-01 00:00:00

  • Analyzing the relationship of exercise and health: methods, assumptions, and limitations.

    abstract::The papers in this supplement to Medicine and Science in Sports and Exercise seek to summarize our knowledge of the dose-response relationship of exercise with a variety of health outcomes. This type of rigorous evidence summation has become quite popular in the past 10 years as health care providers and policymakers ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200106001-00004

    authors: Schriger DL

    更新日期:2001-06-01 00:00:00

  • Cocaine and exercise: physiological responses of cocaine-conditioned rats.

    abstract::To compare the physiological response to a cocaine-exercise challenge in cocaine-conditioned animals with that of acute-cocaine animals, rats were injected i.p. with either cocaine (20 mg.kg-1) or saline, twice daily for 14 consecutive days. On the 15th day (test day) cocaine-conditioned rats received an i.v. injectio...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Kelly KP,Han DH,Fellingham GW,Winder WW,Conlee RK

    更新日期:1995-01-01 00:00:00

  • Anabolic steroid associated to physical training induces deleterious cardiac effects.

    abstract:PURPOSE:Cardiac aldosterone might be involved in the deleterious effects of nandrolone decanoate (ND) on the heart. Therefore, we investigated the involvement of cardiac aldosterone, by the pharmacological block of AT1 or mineralocorticoid receptors, on cardiac hypertrophy and fibrosis. METHODS:Male Wistar rats were r...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318217e8b6

    authors: Do Carmo EC,Fernandes T,Koike D,Da Silva ND Jr,Mattos KC,Rosa KT,Barretti D,Melo SF,Wichi RB,Irigoyen MC,de Oliveira EM

    更新日期:2011-10-01 00:00:00

  • Measuring total and domain-specific sitting: a study of reliability and validity.

    abstract:PURPOSE:Although independent relationships between sitting behaviors (mainly television viewing) and health outcomes have been reported, few studies have examined the measurement properties of self-report sitting questions. This study assessed gender-specific test-retest reliability and validity of a questionnaire that...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181c5ec18

    authors: Marshall AL,Miller YD,Burton NW,Brown WJ

    更新日期:2010-06-01 00:00:00

  • Aerobic fitness affects cortisol responses to concurrent challenges.

    abstract:PURPOSE:Studies have demonstrated that a combination of mental and physical challenge can elicit exacerbated state anxiety, effort sense, and cortisol responses above that of a single stimulus. However, an analysis of the effects of aerobic fitness on the responses of cortisol to concurrent mental and physical stress b...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e318270b381

    authors: Webb HE,Rosalky DS,Tangsilsat SE,McLeod KA,Acevedo EO,Wax B

    更新日期:2013-02-01 00:00:00

  • Magnetic resonance imaging of the shoulder in the primary care setting.

    abstract::MRI is an excellent noninvasive method of diagnosing difficult shoulder problems. Although usually not needed for classic primary impingement syndrome or clinically obvious rotator cuff tears, MRI may be helpful in diagnosing secondary causes of impingement or in some cases involving partial rotator cuff tears. Some s...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:10.1097/00005768-199804001-00002

    authors: Ertl JP,Kovacs G,Burger RS

    更新日期:1998-04-01 00:00:00

  • Genome-wide linkage scan for physical activity levels in the Quebec Family study.

    abstract:PURPOSE AND METHODS:It is commonly recognized that there is familial aggregation for physical activity level. However, the genes and sequence variants responsible for the familial clustering have not been investigated. We performed a genome-wide linkage scan based on 432 markers typed in 767 subjects from 207 families ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.MSS.0000078937.22939.7E

    authors: Simonen RL,Rankinen T,Perusse L,Rice T,Rao DC,Chagnon Y,Bouchard C,Quebec Family Study.

    更新日期:2003-08-01 00:00:00

  • Influence of cardiorespiratory fitness on lung cancer mortality.

    abstract:PURPOSE:Previous studies have suggested that higher levels of physical activity may lower lung cancer risk; however, few prospective studies have evaluated lung cancer mortality in relation to cardiorespiratory fitness (CRF), an objective marker of recent physical activity habits. METHODS:Thirty-eight thousand men, ag...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181c47b65

    authors: Sui X,Lee DC,Matthews CE,Adams SA,Hébert JR,Church TS,Lee CD,Blair SN

    更新日期:2010-05-01 00:00:00

  • Measuring changes in aerodynamic/rolling resistances by cycle-mounted power meters.

    abstract:PURPOSE:To develop a protocol for isolating changes in aerodynamic and rolling resistances from field-based measures of power and velocity during level bicycling. METHODS:We assessed the effect of body position (hands on brake hoods vs drops) and tire pressure changes (414 vs 828 kPa) on aerodynamic and rolling resist...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181fcb140

    authors: Lim AC,Homestead EP,Edwards AG,Carver TC,Kram R,Byrnes WC

    更新日期:2011-05-01 00:00:00

  • Heart rate variability during night sleep and after awakening in overtrained athletes.

    abstract:PURPOSE:This study was conducted to test the hypothesis of autonomic imbalance in overtrained athletes during sleep and after awakening with analyses of heart rate variability (HRV) and nocturnal urine stress hormones. METHODS:We examined 12 athletes diagnosed to be severely overtrained (OA, 6 men and 6 women, mean ag...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000184631.27641.b5

    authors: Hynynen E,Uusitalo A,Konttinen N,Rusko H

    更新日期:2006-02-01 00:00:00

  • The isometric torque at which knee-extensor muscle reoxygenation stops.

    abstract:PURPOSE:We investigated the knee-extensor torque at which reoxygenation (inflow of arterial blood) during an isometric contraction stopped, whether this torque depended on maximal torque capacity (MTC), and whether there were differences among the synergists. METHODS:Isometric knee-extension torque was measured using ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/mss.0b013e31802dd3cc

    authors: de Ruiter CJ,Goudsmit JF,Van Tricht JA,de Haan A

    更新日期:2007-03-01 00:00:00

  • Exercise training increases heat shock protein in skeletal muscles of old rats.

    abstract:PURPOSE:The effects of chronic exercise training on the expression of heat shock protein (HSP) in skeletal muscle of senescent animals are unknown. Therefore, the purpose of this study was to investigate the effects of chronic exercise training on skeletal muscle HSP expression in both young and old rats. METHODS:Youn...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1097/00005768-200105000-00008

    authors: Naito H,Powers SK,Demirel HA,Aoki J

    更新日期:2001-05-01 00:00:00

  • Direct calorimetry and the energetics of exercise and weight loss.

    abstract::Laboratory studies using direct calorimetry, a technique which is no longer either rare or difficult, have shown no essential differences between men and women who gain weight easily and the always lean. Both groups gained weight similarly when overeating by 1,000 kcal X d-1. Thermogenic responses to eating and the en...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Webb P

    更新日期:1986-02-01 00:00:00

  • Age Modulates Physiological Responses during Fan Use under Extreme Heat and Humidity.

    abstract:PURPOSE:We examined the effect of electric fan use on cardiovascular and thermoregulatory responses of nine young (26 ± 3 yr) and nine aged (68 ± 4 yr) adults exposed to extreme heat and humidity. METHODS:While resting at a temperature of 42°C, relative humidity increased from 30% to 70% in 2% increments every 5 min. ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0000000000001348

    authors: Gagnon D,Romero SA,Cramer MN,Kouda K,Poh PYS,Ngo H,Jay O,Crandall CG

    更新日期:2017-11-01 00:00:00

  • Exercise-induced cardiac troponin T release: a meta-analysis.

    abstract:PURPOSE:Cardiac troponin T (cTnT) is a highly specific marker of myocardial damage and used clinically in the diagnosis of acute myocardial infarction (AMI). Release of cTnT has been demonstrated in several small studies after endurance exercise. The purpose of this study was to explore, using a meta-analytic approach,...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,meta分析

    doi:10.1249/mss.0b013e318153ff78

    authors: Shave R,George KP,Atkinson G,Hart E,Middleton N,Whyte G,Gaze D,Collinson PO

    更新日期:2007-12-01 00:00:00

  • Effect of blood flow restriction on tissue oxygenation during knee extension.

    abstract:PURPOSE:Time-resolved near-infrared spectroscopy was used to quantify tissue oxy- and deoxyhemoglobin concentrations ([HbO2] and [HbR]) and O2 saturation (stO2) in the oblique fibers of the vastus medialis muscle and brain prefrontal cortex during knee extension with and without blood flow restriction (BFR). METHODS:S...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000000393

    authors: Ganesan G,Cotter JA,Reuland W,Cerussi AE,Tromberg BJ,Galassetti P

    更新日期:2015-01-01 00:00:00

  • The physical condition of elderly women differing in habitual physical activity.

    abstract::In a cross-sectional study, 50 elderly women (age 71.5 +/- 4.2 yr, mean +/- SD) participated in a battery of tests assessing several aspects of physical fitness. The women were selected based on tertiles of habitual physical activity as determined by a validated questionnaire 10 months ago. The tests comprised the fol...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Voorrips LE,Lemmink KA,van Heuvelen MJ,Bult P,van Staveren WA

    更新日期:1993-10-01 00:00:00

  • EASY-An Instrument for Surveillance of Physical Activity in Youth.

    abstract:PURPOSE:Physical activity (PA) promotion among youth is a public health priority, and there is a need for robust surveillance systems to help support such initiatives. Existing youth PA self-report instruments that are used for surveillance lack information regarding the types and contexts of activity. Further, these i...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0000000000001562

    authors: Pate RR,McIver KL,Dowda M,Schenkelberg MA,Beets MV,Distefano C

    更新日期:2018-06-01 00:00:00

  • Muscular strength and incident hypertension in normotensive and prehypertensive men.

    abstract:UNLABELLED:The protective effects of cardiorespiratory fitness (CRF) on hypertension (HTN) are well known; however, the association between muscular strength and incidence of HTN has yet to be examined. PURPOSE:This study evaluated the strength-HTN association with and without accounting for CRF. METHODS:Participants...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/MSS.0b013e3181b2f0a4

    authors: Maslow AL,Sui X,Colabianchi N,Hussey J,Blair SN

    更新日期:2010-02-01 00:00:00

  • Prevalence of allergy and asthma symptoms in recreational roadrunners.

    abstract:PURPOSE:The prevalence of allergy and asthma symptoms and asthma medication use, which has been extensively studied in elite athletes, has received little attention in recreational roadrunners. METHODS:A validated questionnaire was used to determine the prevalence of allergy and asthma symptoms, the use of medication,...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000235357.31932.43

    authors: Randolph CC,Dreyfus D,Rundell KW,Bangladore D,Fraser B

    更新日期:2006-12-01 00:00:00

  • Alteration of trabecular bone under chronic beta2 agonists treatment.

    abstract:PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were d...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000177592.82507.95

    authors: Bonnet N,Brunet-Imbault B,Arlettaz A,Horcajada MN,Collomp K,Benhamou CL,Courteix D

    更新日期:2005-09-01 00:00:00

  • Effects of resistance training on adiposity and metabolism after spinal cord injury.

    abstract:PURPOSE:This pilot work was conducted to evaluate the effects of neuromuscular electrical stimulation resistance training (RT) of the paralyzed knee extensor muscle groups on skeletal muscle and intramuscular fat (IMF) cross-sectional areas, trunk visceral adipose tissue (VAT), carbohydrate, and lipid profiles in men w...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,随机对照试验

    doi:10.1249/MSS.0b013e31822672aa

    authors: Gorgey AS,Mather KJ,Cupp HR,Gater DR

    更新日期:2012-01-01 00:00:00

  • Physiological changes with periodized resistance training in women tennis players.

    abstract:PURPOSE:To compare the physiological and performance adaptations between periodized and nonperiodized resistance training in women collegiate tennis athletes. METHODS:Thirty women (19 +/- 1 yr) were assigned to either a periodized resistance training group (P), nonperiodized training group (NV), or a control group (C)...

    journal_title:Medicine and science in sports and exercise

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005768-200301000-00024

    authors: Kraemer WJ,Hakkinen K,Triplett-Mcbride NT,Fry AC,Koziris LP,Ratamess NA,Bauer JE,Volek JS,McConnell T,Newton RU,Gordon SE,Cummings D,Hauth J,Pullo F,Lynch JM,Fleck SJ,Mazzetti SA,Knuttgen HG

    更新日期:2003-01-01 00:00:00

  • Inheritance of acute cardiac changes during bicycle exercise: an echocardiographic study in twins.

    abstract::The inheritance of cardiac changes during acute dynamic physical exercise was studied in 21 pairs of monozygotic and 12 pairs of dizygotic male twins, ages 18-31 yr. Echocardiography was performed in resting conditions and at submaximal supine bicycle exercise at a heart rate of 110 bpm. In resting conditions signific...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:

    authors: Bielen EC,Fagard RH,Amery AK

    更新日期:1991-11-01 00:00:00

  • Measurement of social physique anxiety in early adolescence.

    abstract:PURPOSE:The present study assessed the factorial validity and gender invariance of the Social Physique Anxiety Scale (SPAS) using a sample of young adolescents. Existing SPAS 12-item, one- and two-factor and truncated, one-factor (i.e., nine-item and seven-item) measurement models reported in the adult literature were ...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章

    doi:10.1249/01.mss.0000117111.76228.bf

    authors: Smith AL

    更新日期:2004-03-01 00:00:00

  • Prophylactic lateral knee braces.

    abstract::Since the first reported use of knee braces for prophylactic purposes in 1979, these braces have gone through a period of widespread popularity and use, followed by increasing skepticism as to their effectiveness. Early use was unsupported by significant clinical or laboratory data. Multiple studies regarding prophyla...

    journal_title:Medicine and science in sports and exercise

    pub_type: 杂志文章,评审

    doi:

    authors: Johnston JM,Paulos LE

    更新日期:1991-07-01 00:00:00