No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue.

Abstract:

:Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that the mechanisms of muscle fatigue do not occur in isolation in vivo: muscular work is supported by many complex physiological systems, any of which could fail during exercise and thus contribute to fatigue. To advance our overall understanding of fatigue, a combination of models and approaches is necessary. In this review, we examine the roles that neuromuscular properties, intracellular glycogen, oxygen metabolism, and blood flow play in the fatigue process during exercise and pathological conditions.

journal_name

Med Sci Sports Exerc

authors

Kent JA,Ørtenblad N,Hogan MC,Poole DC,Musch TI

doi

10.1249/MSS.0000000000001052

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

2281-2293

issue

11

eissn

0195-9131

issn

1530-0315

journal_volume

48

pub_type

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