Abstract:
:Muscle fatigue has been studied with a variety approaches, tools and technologies. The foci of these studies have ranged tremendously, from molecules to the entire organism. Single cell and animal models have been used to gain mechanistic insight into the fatigue process. The theme of this review is the concept that the mechanisms of muscle fatigue do not occur in isolation in vivo: muscular work is supported by many complex physiological systems, any of which could fail during exercise and thus contribute to fatigue. To advance our overall understanding of fatigue, a combination of models and approaches is necessary. In this review, we examine the roles that neuromuscular properties, intracellular glycogen, oxygen metabolism, and blood flow play in the fatigue process during exercise and pathological conditions.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Kent JA,Ørtenblad N,Hogan MC,Poole DC,Musch TIdoi
10.1249/MSS.0000000000001052subject
Has Abstractpub_date
2016-11-01 00:00:00pages
2281-2293issue
11eissn
0195-9131issn
1530-0315journal_volume
48pub_type
杂志文章,评审abstract:PURPOSE:The purpose of this investigation was to examine the effects of differing amounts of beta-hydroxy-beta-methylbutyrate (HMB), 0, 36, and 76 mg x kg(-1) x d(-1), on hematology, hepatic and renal function during 8 wk of resistance training. METHODS:Thirty-seven, untrained collegiate males and were randomly assign...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200012000-00023
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:The present study examined the effect of extreme old age on the plasticity of the rat plantaris muscle in response to an increase in mechanical load. METHODS:Male Fischer 344 rats, aged 7 months (adult) and 25 months (old) underwent bilateral surgical ablation of the gastrocnemius muscle to functionally overlo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200207000-00010
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001082
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Considering the different loading and training characteristics of the sports practiced during growth, it is important to specify and categorize the bone and soft tissue adaptations in adolescent athletes. This study aimed to categorize 10 different loading sports and a nonsport group and identify the difference...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002420
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:This study aimed to analyze the influence of foot strike pattern on running economy and biomechanical characteristics in subelite runners with a similar performance level. METHODS:Twenty subelite long-distance runners participated and were divided into two groups according to their foot strike pattern: rearfoo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000139
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:It has been well established in mammals that circadian behavior as well as the molecular clockwork can be synchronized to the light-dark cycle via the suprachiasmatic nucleus of the hypothalamus (SCN). In addition to light, it has been demonstrated that nonphotic time cues, such as restricting the time of food ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318255cf4c
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abstract:INTRODUCTION:Acute stress can increase fatigability and decrease steadiness of sustained low-force contractions that are required for functional tasks in upper limb muscles. Whether motor performance is more impaired in people with a chronic stress disorder is not known. PURPOSE:This study compared the fatigability an...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000244
更新日期:2014-07-01 00:00:00
abstract::Estimates of muscular efficiency in competitive and recreational cyclists at similar work intensities and cycling frequencies were examined. Twelve healthy college-age male nonsmoker volunteers were grouped as either competitive (CC; N = 6) or recreational (RC; N = 6) cyclists based upon previous cycling experience. S...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-199611000-00008
更新日期:1996-11-01 00:00:00
abstract:PURPOSE:To determine the prevalence of full-thickness focal chondral defects in the athlete's knee. METHODS:We conducted a systematic review of multiple databases, evaluating studies of the prevalence of articular cartilage defects in athletes. Because of the heterogeneity of data, a meta-analysis could not be perform...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0b013e3181d9eea0
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:The purpose of this study is to compare the time-frequency characteristic, using nonlinearly scaled wavelets, of the EMG signal as well as the three-dimensional (3D) knee kinematics of female and male elite soccer players performing an unanticipated cutting maneuver. METHODS:Fifteen female and 15 male elite so...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31817b8e9e
更新日期:2008-10-01 00:00:00
abstract::This study examined the association between aerobic, caloric exercise expenditure and life status (living vs deceased) as well as the prevalence rates of hypertension (HBP) and cardiovascular disease (CVD) in former male athletes (ATH) and non-athletes (N-ATH). The initial survey for this study was done in 1952. Follo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199012000-00002
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:To examine the effect of an increase in roller ski rolling resistance on the physiological and upper body demands of roller skiing with the V2-alternate technique. METHODS:Nine highly skilled cross-country skiers roller skied at three paced speeds on a flat oval loop using roller skis with high (HiR) and low...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199805000-00018
更新日期:1998-05-01 00:00:00
abstract::The purpose of this project was to determine whether mild heat stress induced by wearing a wet suit while swimming in relatively warm water (25.4 +/- 0.1 degrees C) increases the risk of heat injury during the cycling and running stages of an International distance triathlon in a hot and humid environment (32 degrees ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199801000-00014
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Previous research identified decreased overall and cardiovascular mortality for National Football League (NFL) players from the 1959-1988 era. The present study explored the mortality risk among recent NFL players who played in an era of heavier linemen and nearly year-round physical conditioning. METHODS:This...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001466
更新日期:2018-03-01 00:00:00
abstract:UNLABELLED:Two recently identified glucose transporters, GLUT8 and GLUT12, are expressed in human skeletal muscle and may be involved in insulin-mediated sugar transport. PURPOSE:The purpose of this study was to measure GLUT8 and GLUT12 mRNA levels in endurance-trained versus sedentary individuals in an effort to dete...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000222837.74015.f1
更新日期:2006-06-01 00:00:00
abstract::The purpose of this study was to determine whether efferent sympathetic nerve activity is different to resting skeletal muscles from the exercising and nonexercising limb. MSNA was measured by microneurography in both legs (peroneal nerve) in six subjects during 2 min of unilateral isometric knee extension (IKE; 10-30...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:A combination of endurance and strength training is generally used to seek further health benefits or enhanced physical performance in older adults compared with either of the training modes alone. The mean change within a training group, however, may conceal a wide range of individual differences in the respon...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181f1bf0d
更新日期:2011-03-01 00:00:00
abstract::To test a hypothesis that the differences in running performances between men and women narrow with increasing race distance, recent best running speeds (m.s-1) of 28 female ultramarathon runners over racing distances from 5 to 90 km were compared with those of male runners matched for 56 km race time, age and trainin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199702000-00013
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318145b337
更新日期:2007-11-01 00:00:00
abstract::MRI is an excellent noninvasive method of diagnosing difficult shoulder problems. Although usually not needed for classic primary impingement syndrome or clinically obvious rotator cuff tears, MRI may be helpful in diagnosing secondary causes of impingement or in some cases involving partial rotator cuff tears. Some s...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199804001-00002
更新日期:1998-04-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31825f69f3
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:Loud sounds can decrease reaction time (RT) and increase force generated during voluntary contractions. Accordingly, we hypothesized that the loud starter's pistol at the Olympic Games allows runners closer to the starter to react sooner and stronger than runners farther away. METHODS:RT for the 100/110 m...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31816770e1
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To test the hypothesis that leg blood flow and leg O2 extraction during peak exercise are reduced with age in healthy normally active women. METHODS:Thirteen younger (20-27 yr) and 12 older (60-71 yr) nonendurance trained women performed graded upright leg cycling to maximum exertion (VO2peak), while leg blood...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
abstract::The purpose of this study was to identify anatomical variables associated with plantar-fasciitis sufferers. Selected anatomical variables which were chosen for measurement were leg length, pronation of the subtalar joint, plantar and dorsiflexion ability, and arch height of the foot, as well as the variables height, w...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:This study aimed to determine whether physical activity patterns are associated with sleep later at night and if nighttime sleep is associated with physical activity patterns the next day among adult women. METHODS:Women (N = 353) living throughout the United States wore a wrist and a hip accelerometer for 7 d...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001000
更新日期:2016-10-01 00:00:00
abstract:PURPOSE:Although several studies have shown that immune cells stimulated by in vitro stress are capable to produce neurotrophins, there is still no evidence whether physiological stress, such as exercise, can modulate the in vivo levels of brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31825ab69b
更新日期:2012-10-01 00:00:00
abstract::The physiological mechanism of exercise-induced hyperfibrinolysis is not fully understood. It has been reported that exercise increases plasma arginine vasopressin (PAVP) and that PAVP infusion enhances blood fibrinolytic activity (FA). To characterize the fibrinolytic role of PAVP during exercise, PAVP and FA were ex...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Older adults have low rates meeting the physical activity (PA) guidelines and high sedentary time. Low PA and excessive sedentary time have been linked to adverse health outcomes. Less is known about whether exercise training influences sedentary time and PA in various intensities. PURPOSE:This study aimed to examine...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002407
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:This study aimed to test whether incident kidney cancer risk is associated with exercise energy expenditure (i.e., metabolic equivalents, 1 MET) when calculated from distance walked or run. METHODS:Hazard ratios (HR) and 95% confidence intervals (95% CI) from Cox proportional hazard analyses of self-reported p...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182a4e89c
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:A 20-d 6 degrees head-down tilt bed rest project was conducted to evaluate the effect of dynamic leg press and plantar flexion resistance training on muscle size and function in human plantar flexors (PF) throughout the prolonged bed rest. METHODS:Twelve healthy men participated in this study and were divided ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-04-01 00:00:00