Aging does not attenuate plantaris muscle hypertrophy in male Fischer 344 rats.

Abstract:

PURPOSE:The present study examined the effect of extreme old age on the plasticity of the rat plantaris muscle in response to an increase in mechanical load. METHODS:Male Fischer 344 rats, aged 7 months (adult) and 25 months (old) underwent bilateral surgical ablation of the gastrocnemius muscle to functionally overload (OV) the fast-twitch plantaris muscle for 8 wk RESULTS:At 27 months of age, plantaris wet weight and cross-sectional area (CSA) were unaffected by age, but aging decreased peak isometric tension (Po) 27% (P < 0.05). Plantaris muscle myosin heavy chain composition indicated a loss of faster myosin heavy chains (MHC) isoforms with concomitant increases in slower MHC in old rats (P < 0.05). In adult rats, OV increased muscle CSA and Po 72% and 83%, respectively (P < 0.05). Similarly, OV increased CSA and Po 69% and 73%, respectively, in old rats (P < 0.05). Average fiber CSA increased 57% and 68% in adult-OV and old-OV rats, respectively (P < 0.05). CONCLUSION:Collectively, our data indicate that plantaris muscle mass and plasticity in response to increased mechanical load are well conserved in very aged male Fischer 344 rats.

journal_name

Med Sci Sports Exerc

authors

Linderman JK,Blough ER

doi

10.1097/00005768-200207000-00010

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

1115-9

issue

7

eissn

0195-9131

issn

1530-0315

journal_volume

34

pub_type

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