Abstract:
PURPOSE:Although several studies have shown that immune cells stimulated by in vitro stress are capable to produce neurotrophins, there is still no evidence whether physiological stress, such as exercise, can modulate the in vivo levels of brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMCs). METHODS:This work investigated whether acute exercise modulates the expression of BDNF, pro-BDNF, and p75(NTR) in the PBMCs of 10 healthy young men who performed a cycling incremental test to exhaustion (MAX) or exercised at individual anaerobic threshold (IAT). The PBMC expression of stress response proteins and the level of circulating BDNF, vascular endothelial growth growth factor, platelet-derived growth factor subunit B, basic fibroblast growth factor pro-inflammatory, and anti-inflammatory cytokines were analyzed as well. RESULTS:A major finding is that both sessions of acute exercise regulated the content of BDNF isoforms within PBMCs in a manner related to the physiological stress exerted. Although the pro-BDNF increased after both MAX and IAT protocols, BDNF showed a kinetics dependent on exercise type: MAX induced a 54% protein increase immediately after exercise, followed by a significant drop 60 min after its conclusion (38% lower than the baseline). Differently, in the IAT, BDNF increased significantly up to 75% from the baseline throughout the recovery phase. All physiological parameters, as well as the p75(NTR) receptor and the stress-inducible proteins, were also differently regulated by the two exercise conditions. CONCLUSIONS:These data supported the hypothesis that PBMCs might produce and secrete BDNF isoforms, as well as modulate the proteins p75(NTR) , Bcl-xL, hsp90, hsp27, and αB-crystallin, as part of the physiological stress response induced by acute exercise, offering a novel example of bidirectional interaction between nervous and immune systems.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Brunelli A,Dimauro I,Sgrò P,Emerenziani GP,Magi F,Baldari C,Guidetti L,Di Luigi L,Parisi P,Caporossi Ddoi
10.1249/MSS.0b013e31825ab69bsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1871-80issue
10eissn
0195-9131issn
1530-0315journal_volume
44pub_type
杂志文章abstract:PURPOSE:The effect of quantified resistance and high impact exercise training on bone mass as modified by age and oral contraceptive (OCont) use in young women was studied. METHODS:Women were categorized by age (18-23 vs 24-31 yr) and OCont use, and were then randomized into either three sessions of resistance exercis...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200106000-00004
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abstract:PURPOSE:The objectives of this study were to: 1) establish a database of kinematic and EMG data during cutting movements, 2) describe normal muscle function and coordination of 12 lower extremity muscles during cutting movements susceptible to ankle sprains, and 3) identify potential muscle coordination deficiencies th...
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pub_type: 杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
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doi:
更新日期:1987-08-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:It is often reported that females lose less body weight than males do in response to exercise. These differences are suggested to be a result of females exhibiting a stronger defense of body fat and a greater compensatory appetite response to exercise than males do. PURPOSE:This study aimed to compare the e...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1984-12-01 00:00:00