Abstract:
:Chronically increased contractile activity by low-frequency stimulation induces a transformation of fast- into slow-twitch muscle fibers in the rabbit. This transformation is progressive with the duration of the stimulation and affects various functional systems of the muscle fiber in an orderly sequence. Early changes in enzyme activities and isozymes of energy metabolism result in a "white to red" metabolic transformation. Simultaneously, cytosolic Ca2+-binding and Ca2+-sequestration are reduced by a decrease in parvalbumin and a transformation of the sarcoplasmic reticulum membranes. The fast to slow transformation is completed by an exchange of fast with slow-type myosin isoforms. Changes in total RNA and qualitative and quantitative alterations in translatable mRNA indicate that the various transitions result from altered translational and transcriptional activities. The qualitative similarity of changes evoked by long-term endurance training suggest that fast to slow transitions represent a regular response to increased contractile activity. The specific time courses at which various functional systems of the fiber respond, point to the existence of different thresholds. These differences increase the adaptability of the fiber by changing its properties in a graded fashion. The phenotype of a muscle fiber appears thus to be dynamic and is modified according to the actual functional demand.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Pette Dsubject
Has Abstractpub_date
1984-12-01 00:00:00pages
517-28issue
6eissn
0195-9131issn
1530-0315journal_volume
16pub_type
杂志文章,评审abstract:PURPOSE:The development of valid measures of built environments relevant for physical activity is an important step toward controlling the global epidemic of physical inactivity-related noncommunicable diseases and deaths. This study assessed the construct validity of a self-report neighborhood environment walkability ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001131
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Traction-induced injury, related to muscles of the superficial and deep posterior compartments, has been implicated as the cause of medial tibial stress syndrome (MTSS) with symptoms commonly occurring in the distal third of the posteromedial tibia. Standard anatomic texts do not identify this region as an atta...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181a6519c
更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION/PURPOSE:To examine whether fluctuations in training load during an Olympic year lead to changes in bone mineral densities and factors that regulate bone (sclerostin, osteoprotegerin and receptor activator of nuclear factor kappa-B ligand), energy metabolism (insulin-like growth factor-1 and leptin), and in...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001640
更新日期:2018-09-01 00:00:00
abstract::The purpose of this study was to compare gastric emptying (GE) responses during intense, prolonged cycling and running. It is important to discern whether gastric emptying (GE) responses are exercise-mode specific, since the findings of cycling and running studies are often compared and applied to one another. Ten mal...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate and improve the accuracy of accelerometer-type pedometers used by the elderly with slow walking speeds, with or without gait disorders, who do or do not use a cane. METHODS:Eighteen subjects walked with a cane (5 males, 13 females; age, 80.9 +/- 7.7 yr; height, 148.1 +/...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000227641.68360.c2
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:Obesity is epidemic in Western societies, with rapid rates of increase in the young. Various methods exist for the assessment of body composition, but these have not been compared in obese children and adolescents. This study compared methods of body composition assessment in obese young people to determine whe...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000191160.07893.2d
更新日期:2006-03-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to identify unique organized sport trajectories from early childhood to late adolescence in an Australian pregnancy cohort, the Raine Study. METHODS:Participation in organized sport was assessed at ages 5, 8, 10, 14, and 17 yr. Physical activity, body composition, and self-ra...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000894
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To determine whether physical activity and fitness change in girls with and without a predisposition to obesity from 8 to 10 yr of age. METHODS:Normal-weight girls (N = 91) were recruited at 8 yr of age according to parental body mass index (BMI): LN = girls with two lean (BMI < 25 kg.m-2) parents, LNOB = girl...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000113666.98463.B0
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS:Therefore, we investigated cardia...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0b013e31821b12eb
更新日期:2011-10-01 00:00:00
abstract::Participation in sports in on the increase; this article addresses the intersection of sports and infectious diseases. Some infections occur with increased incidence in sports; others have an increased impact in that setting. Addressed in this article are issues of diagnosis, prevention, and management of many of thes...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-200007001-00008
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:High-throughput profiling of metabolic status (metabolomics) allows for the assessment of small-molecule metabolites that may participate in exercise-induced biochemical pathways and corresponding cardiometabolic risk modification. We sought to describe the changes in a diverse set of plasma metabolite profiles...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001594
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the vibrotactile detection thresholds of the plantar cutaneous afferents in subjects with chronic ankle instability compared with healthy control subjects. METHODS:Eight adults with chronic ankle instability and eight adults with no ankle sprain history participated...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182390212
更新日期:2012-04-01 00:00:00
abstract::The gravity-dependency and age-dependency of noradrenergic vasoconstrictor outflow to skeletal muscle (muscle sympathetic nerve activity; MSNA) in humans was analyzed by applying microneurography technique. The basal level of MSNA in the horizontally supine position increased with aging without significant changes in ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199610000-00039
更新日期:1996-10-01 00:00:00
abstract::Data obtained from 16-mm film of world caliber Olympic weight lifters performing at major competitions were analyzed to study energy changes during body segment and barbell movements, energy transfer to the barbell, and energy transfer between segments during the lifting movements contested. Determination of barbell a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Cardiovascular responses were obtained during cycling with graded levels of lower-body positive pressure (LBPP) applied to the exercising limbs. Seven men performed four incremental work rate (25 W.min-1) exercise (IWREx) tests to their limit of tolerance while exposed to 0, 15, 30, or 45 Torr LBPP. They also performe...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-199406000-00008
更新日期:1994-06-01 00:00:00
abstract:PURPOSE:This study investigated whether flexibility training would attenuate muscle damage induced by maximal eccentric exercise. METHODS:Thirty untrained young men were allocated to static stretching (SS), proprioceptive neuromuscular facilitation (PNF), or control group (n = 10 per group). The SS consisted of 30 set...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181f315ad
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was twofold: (a) to measure the effects of temporal parameters on both ball velocity and upper limb joint kinetics to identify pathomechanical factors during the tennis serve and (b) to validate these pathomechanical factors by comparing injured and noninjured players. METHODS:The ser...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318299ae3b
更新日期:2013-11-01 00:00:00
abstract::The close balance between the O2 requirement to perform exercise and the O2 supply was analyzed. A non-uniform capillary PO2 can result in anaerobic metabolism in some muscle fibers despite an apparently adequate mean capillary PO2. The pattern of lactate increase for constant work rates and incremental exercise is de...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198606000-00017
更新日期:1986-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether muscle power, activation time, and neuromuscular stimulation are related to physical activity patterns in older women. METHODS:Forty women (65-84 yr) were assigned to high-active (HA) and low-active (LA) groups on the basis of a historical activity questionnai...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318074ccd9
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:This study aimed to compare the efficacy of eccentrically focused resistance exercise (ECC RT) to concentrically focused resistance exercise (CNC RT) on knee osteoarthritis (OA) symptoms and strength. METHODS:Ninety participants consented. Participants were randomized to CNC RT, ECC RT, or a wait-list, no...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000002010
更新日期:2019-10-01 00:00:00
abstract::Ten experienced weight lifters were studied to determine the influence of strenuous, free-weight, squat lift exercise on changes in plasma volume, mean arterial pressure, and the rate pressure product. After a 40-min postural adjustment prior to upright exercise, each subject completed eight sets of eight repetitions ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:PURPOSE:Cross-sectional studies suggest that training can increase muscle carnosine (MCarn), although longitudinal studies have failed to confirm this. A lack of control for dietary β-alanine intake or muscle fiber type shifting may have hampered their conclusions. The purpose of the present study was to investigate th...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000001697
更新日期:2018-11-01 00:00:00
abstract::To test whether strenuous exercise with and without caloric restriction alters LH secretion, and whether these changes are apparent in the immediate post-exercise period, LH pulse parameters were studied in four moderately trained eumenorrheic women over three successive menstrual cycles. Blood samples were obtained 5...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-10-01 00:00:00
abstract:PURPOSE:To test our hypothesis that differences in urinary calcium excretion among blacks and whites may be secondary to ethnic variations in acid (H(+)) metabolism and to prove that increases in titratable acid excretion would be found among individuals predisposed to the development of stress fractures. METHODS:We a...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200202000-00018
更新日期:2002-02-01 00:00:00
abstract:PURPOSE:The effect of exercise on body mass is likely to be partially mediated through changes in appetite control. However, no studies have examined the effect of chronic exercise on obestatin and cholecystokinin (CCK) plasma concentrations or the sensitivity to detect differences in preload energy in obese individual...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31827d1618
更新日期:2013-05-01 00:00:00
abstract::Two swims (1993 and 1994) are described which led to post-swim orthostatic intolerance and one episode of syncope in a 50/51-yr-old well-trained and experienced marathon swimmer. The swims of 33 km and 38 km took 12 h 30 s and 17 h 35 min, respectively. Water temperature in each swim was above 23 degrees C and rectal ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::In an effort to determine whether chronic physical forearm activity would increase both structural and physiologic indices of peripheral forearm vasodilation, we studied a group (N = 7) of individuals chronically performing high levels of arm work, young wheelchair-confined paraplegics, and compared them with ten youn...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine whether similar patterns of quadriceps dysfunction are observed when people with anterior cruciate ligament (ACL) deficiency perform static and dynamic tasks. METHODS:EMG data were collected from 15 subjects with an ACL deficient knee and 15 uninjured subjects as they...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000131959.20666.11
更新日期:2004-07-01 00:00:00
abstract:PURPOSE:Temperature increase, oxidative stress, and inflammatory reactions after endurance exercise were expected to stimulate the synthesis of heat shock proteins (HSP) in peripheral blood leukocytes. Furthermore, it was of interest whether regular endurance training influences HSP expression. METHODS:The expression ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200003000-00007
更新日期:2000-03-01 00:00:00
abstract:INTRODUCTION:Slow gait predicts many adverse clinical outcomes in old adults, but the mechanisms of how power training can minimize the age-related loss of gait velocity is unclear. We examined the effects of 10 wk of lower extremity power training and detraining on healthy old adults' lower extremity muscle power and ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001082
更新日期:2017-01-01 00:00:00