Abstract:
INTRODUCTION:Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS:Therefore, we investigated cardiac biomarkers (high-sensitive cardiac troponin T (hs-cTnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), heart-type fatty acid-binding protein (h-FABP)), inflammation markers (high-sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10, tumor necrosis factor-α), and renal function (cystatin C) in 102 healthy men age 42 ± 9 yr before and 0, 24, and 72 h after a marathon. RESULTS:Kinetics of hs-cTnT revealed a peak immediately after the race (V3) that decreased rapidly to pretest values within 72 h (V5) (median (interquartile range) = 31.07 (19.25-46.86) ng·L(-1) at V3 and 3.61 (3.20-6.70) ng·L(-1) at V5, P < 0.001). NT-proBNP and h-FABP kinetics showed a similar pattern (NT-proBNP = 92.6 (56.9-149.7) ng·L(-1) at V3 and 34.9 (21.7-54.5) ng·L(-1) at V5; h-FABP = 44.99 (32.19-64.42) μg·L(-1) at V3 and 7.66 (5.64-10.60) μg·L(-1) at V5; always P < 0.001). Proinflammatory markers, such as IL-6 and hs-CRP, and renal dysfunction were significantly augmented immediately after the race (before the race compared with maximum after the race: IL-6 = 15.5-fold, hs-CRP = 28-fold, cystatin C = 1.22-fold, all P < 0.001). These increases were not related to the increase of hs-cTnT. Similarly, training history, finishing time, and exercise intensity were not associated with changes of hs-cTnT. CONCLUSIONS:Cardiac biomarkers were increased immediately after a marathon race. Interestingly, values returned to normal levels within 72 h. These kinetics with a sharp peak indicate that cardiac necrosis during marathon running seems very unlikely but may be explained by altered myocyte metabolism.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Scherr J,Braun S,Schuster T,Hartmann C,Moehlenkamp S,Wolfarth B,Pressler A,Halle Mdoi
10.1249/MSS.0b013e31821b12ebsubject
Has Abstractpub_date
2011-10-01 00:00:00pages
1819-27issue
10eissn
0195-9131issn
1530-0315journal_volume
43pub_type
临床试验,杂志文章abstract::We investigated the relationship of aerobic fitness to the response of volume-regulating hormones to acute simulated microgravity. Six untrained (UT) and six endurance-trained (ET) healthy young males were studied in the head-down tilt (HDT) position of -6 degrees for 4 h. Peak oxygen uptake (VO2peak) and plasma volum...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:PURPOSE:Identify the prevalence of and traits that may increase the risk of low bone mineral density (BMD) among 93 female adolescent competitive endurance runners. METHODS:Participants were 93 high school runners, ages 13-18 yr, from southern California. Eating attitudes and behaviors were assessed using the Eating D...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181822ea0
更新日期:2008-12-01 00:00:00
abstract::Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E). However, large discrepancies hav...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198512000-00011
更新日期:1985-12-01 00:00:00
abstract:PURPOSE:Since the introduction of carving skis, muscle activity has been investigated primarily on expert-level skiers with respect to EMG intensities. The three-part aim of this recreational skiing study was to analyze functional differences within the quadriceps muscle, to analyze the topographical influence, and to ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181d299cf
更新日期:2010-08-01 00:00:00
abstract::Canine skeletal muscle preparations in situ contain varying mixtures of fast and slow fatigue resistant fibers. All vessels on the arterial side of the vascular bed in these preparations from the conduit arteries to the arterioles contribute to the vascular resistance. The vascular beds autoregulate at rest and during...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/00005768-198810001-00004
更新日期:1988-10-01 00:00:00
abstract::This study compared the effects of exercise or TXB2 and beta-TG when evaluated by four methods: 1) not adjusted; 2) adjusted for plasma volume changes (PV); 3) standardized per 10(5) platelets (PC); 4) or both PC and PV (PC-PV). Blood was collected from 16 men (41.3 +/- 8.1 yr) at rest after 30 min of exercise (IPE) a...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199705000-00018
更新日期:1997-05-01 00:00:00
abstract:PURPOSE:The purpose of this project was to determine the incidence of exercise-induced bronchospasm (EIB) among U.S. Olympic winter sport athletes. METHODS:Subjects included female and male members of the 1998 U.S. Winter Olympic Team from the following sports: biathlon, cross-country ski, figure skating, ice hockey, ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200004000-00003
更新日期:2000-04-01 00:00:00
abstract::Two studies were conducted to test the validity of an all-out procedure for the assessment of the maximal accumulated oxygen deficit (AOD). Subjects in study 1 (N = 9; VO2max = 57 +/- 3 ml.kg-1.min-1 [+/- SEM]) completed three supramaximal efforts on a cycle ergometer. Exhaustive exercise during an all-out isokinetic ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:The purposes of this study was to determine functional movement assessments' ability to predict head impact biomechanics in college football players and to determine whether head impact biomechanics could explain preseason to postseason changes in functional movement performance. METHODS:Participants (N = 44; ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001538
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Scientists and clinicians have attempted to identify and understand biomechanical factors that influence concussion likelihood. The effect of impact frequency to a given head location before the concussion has not been evaluated. The purpose of this study was to compare the frequency of impacts to a given ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000896
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:The aim of the present study was to investigate the changes occurring in leukocyte levels of reactive oxygen species (ROS) and total blood plasma antioxidant capacity (TAS) as a result of a marathon/half-marathon race. METHODS:Fourteen men participating in the Oslo Marathon 2000 and 8 women and 8 men participa...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000106168.12113.95
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine the relative association of physical activity, cardiorespiratory fitness (CRF), and adiposity with C-reactive protein (CRP) in prepubescent children. METHODS:Forty-five prepubescent children (age = 9.4 ± 1.6 yr; 26 boys) were assessed for adiposity (percent fat) via dua...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181e0355e
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:The present study assessed the factorial validity and gender invariance of the Social Physique Anxiety Scale (SPAS) using a sample of young adolescents. Existing SPAS 12-item, one- and two-factor and truncated, one-factor (i.e., nine-item and seven-item) measurement models reported in the adult literature were ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000117111.76228.bf
更新日期:2004-03-01 00:00:00
abstract::Chronically increased contractile activity by low-frequency stimulation induces a transformation of fast- into slow-twitch muscle fibers in the rabbit. This transformation is progressive with the duration of the stimulation and affects various functional systems of the muscle fiber in an orderly sequence. Early change...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1984-12-01 00:00:00
abstract:PURPOSES:To validate the energy expenditure estimated from The Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) with total energy expenditure (TEE) measured by doubly labeled water (DLW), and to present and examine the validity of an extended version of the MLTPAQ with additional questions about inactivi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000093608.95629.85
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:High school cross-country runners have a high incidence of injury, particularly at the shin and knee. An increased step rate during running has been shown to reduce impact forces and loading of the lower extremity joints. The purpose of this prospective study was to examine step rate as a risk factor for injury...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000890
更新日期:2016-07-01 00:00:00
abstract::This article focuses on sports related spinal cord and nerve injuries, ranging from mild "stinger" syndrome to complete quadriplegia. Particular emphasis is placed on recommendations for return to competition after such injuries. Cervical spinal cord symptoms after a spine injury from contact sports require a more pre...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199707001-00005
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Recent work has identified deficits in dual-task gait balance control for up to 2 months after adolescent concussion; however, how resumption of preinjury physical activities affects recovery is unknown. PURPOSE:The objective of this study is to examine how return to activity (RTA) affects recovery from con...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000462
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Physically active women have a reduced risk of breast cancer, but the dose of activity necessary and the role of energy balance and other potential mechanisms have not been fully explored in animal models. We examined treadmill and wheel running effects on mammary tumorigenesis and biomarkers in p53-deficient (...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31819f1f05
更新日期:2009-08-01 00:00:00
abstract::Increased vertical impact loading during running has been associated with a variety of running related injuries including stress fractures, patellofemoral pain, and plantar fasciitis. PURPOSE:The purpose of this study was to examine the acute and long-term effect of a gait retraining program aimed at teaching runners...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001710
更新日期:2018-12-01 00:00:00
abstract::Acute aerobic exercise improves mood and activates the endocannabinoid (eCB) system in physically active individuals; however, both mood and eCB responses to exercise may vary based on habitual levels of physical activity. PURPOSE:This study aimed to examine eCB and mood responses to prescribed and preferred exercise...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001276
更新日期:2017-08-01 00:00:00
abstract::A previous study has shown that subjects who entrain breathing during cycling exhibit a lower oxygen consumption (VO2) compared with random breathing. We sought to investigate the hypothesis that entrainment of breathing during rowing improved biomechanical economy (reduced VO2) compared with spontaneous breathing. A ...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-05-01 00:00:00
abstract:UNLABELLED:Several investigators have demonstrated that chronic eccentric leg cycling is an effective method for improving lower body neuromuscular function (e.g., quadriceps muscle size, strength, and mobility) in a variety of patient and athletic populations. To date, there are no reports of using eccentric arm cycli...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0b013e318269c79c
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of training intensity and duration, through a range representative of training in endurance athletes, on acute recovery of autonomic nervous system (ANS) balance after exercise. METHODS:Nine highly trained (HT) male runners (VO2max 72 +/- 5 mL.kg.min(-1), 14 +/- 3 training hours per ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318060f17d
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate and improve the accuracy of accelerometer-type pedometers used by the elderly with slow walking speeds, with or without gait disorders, who do or do not use a cane. METHODS:Eighteen subjects walked with a cane (5 males, 13 females; age, 80.9 +/- 7.7 yr; height, 148.1 +/...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000227641.68360.c2
更新日期:2006-09-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to identify unique organized sport trajectories from early childhood to late adolescence in an Australian pregnancy cohort, the Raine Study. METHODS:Participation in organized sport was assessed at ages 5, 8, 10, 14, and 17 yr. Physical activity, body composition, and self-ra...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000894
更新日期:2016-07-01 00:00:00
abstract:INTRODUCTION:Acute stress can increase fatigability and decrease steadiness of sustained low-force contractions that are required for functional tasks in upper limb muscles. Whether motor performance is more impaired in people with a chronic stress disorder is not known. PURPOSE:This study compared the fatigability an...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000244
更新日期:2014-07-01 00:00:00
abstract:UNLABELLED:Although effects of workload and cadence on sagittal plane knee biomechanics in cycling have been widely studied, few studies have examined their impact on the frontal plane. PURPOSE:The purpose of this study was to investigate the effects of different workloads and cadences on knee sagittal and frontal pla...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000759
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:The purpose of this study was to test the hypothesis that stretch-activated ion channel (SAC) function is essential for the repeated bout effect (RBE) in skeletal muscle. Specifically, we investigated if daily injections of streptomycin (a known SAC blocker) would abrogate the muscle's adaptive resistance to th...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318187cffa
更新日期:2009-02-01 00:00:00
abstract::Our understanding of the responses of men and women to cold stress is extremely limited. Various scientists have suggested that there could be gender differences in thermoregulatory responses due to sexual dimorphism in body fatness and its distribution, in body surface area, and in mass. In addition, there are also s...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/00005768-198810001-00017
更新日期:1988-10-01 00:00:00