Abstract:
PURPOSE:The purpose of this study was to test the hypothesis that stretch-activated ion channel (SAC) function is essential for the repeated bout effect (RBE) in skeletal muscle. Specifically, we investigated if daily injections of streptomycin (a known SAC blocker) would abrogate the muscle's adaptive resistance to the damaging effects of eccentric exercise over a 4-wk period. Furthermore, we hypothesized that the lack of an RBE would be due to the lack of functional adaptations that typically result from repeated bouts of eccentric exercise, including increased peak isometric torque, muscle hypertrophy, and rightward shift of the torque-angle relationship. METHODS:Twelve New Zealand white rabbits were each subjected to 12 bouts of eccentric exercise over a 4-wk period while receiving either daily injections of streptomycin or sham injections. RESULTS:Although blocking the SAC function completely eliminated the expected adaptive response in biomechanical parameters during the exercise regimen, there remained evidence of an acquired RBE, albeit with an attenuated response when compared with the muscles with intact SAC function. CONCLUSION:Blocking sarcolemmal SAC eliminates functional adaptations of muscle after eccentric exercise. In the absence of SAC function, muscles subjected to chronic eccentric exercise still exhibit some degree of the RBE. As such, it appears that the signaling cascade that results in functional, biomechanical adaptations associated with the RBE during eccentric exercise is dependent upon intact SAC function.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Butterfield TA,Best TMdoi
10.1249/MSS.0b013e318187cffasubject
Has Abstractpub_date
2009-02-01 00:00:00pages
351-6issue
2eissn
0195-9131issn
1530-0315journal_volume
41pub_type
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journal_title:Medicine and science in sports and exercise
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doi:10.1249/MSS.0000000000002234
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e318258bcd5
更新日期:2012-10-01 00:00:00
abstract::Forty male and 40 female rats were randomly assigned to 1 of 4 experimental groups. Half of the animals of each gender were exercised by jumping (weighted by a vest with up to 70% body weight) to a height of 16 cm 20 times X d-1 (30 s between jumps) 5 d X wk-1 for 8 wk. Half of the exercised animals and half of the se...
journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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更新日期:1996-01-01 00:00:00
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更新日期:2020-09-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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更新日期:2004-09-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
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更新日期:2002-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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更新日期:1995-04-01 00:00:00
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更新日期:2000-08-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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更新日期:2015-12-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199701000-00013
更新日期:1997-01-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1991-07-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00