Abstract:
PURPOSE:Exercise training reduces pathological remodeling and improves cardiac function in ischemic heart failure; however, causal mechanisms underlying the cardiac benefits of exercise are poorly understood. Because opening of adenosine triphosphate (ATP)-sensitive K ⁺(KATP) channels protects the heart during myocardial stress, we hypothesized that such a mechanism is responsible for some of the cardiac benefits induced by exercise in postinfarction chronic heart failure (CHF). METHODS:Left ventricular myocytes were isolated from three groups of rats: Sham, CHF Tr (4 wk after myocardial infarction, rats underwent 8 wk of aerobic interval training 5 d·wk⁻¹) and CHF Sed (rats sedentary for 12 wk after infarction). Cardiomyocyte survival after oxidative stress exposure (200 μM H2O2) and calcium handling (cells loaded with Fura-2 AM and electrically paced at 1 Hz) were assessed in the presence of KATP channel inhibitor glibenclamide. Expression of KATP subunits (SUR2A and Kir6.2) was evaluated using immunoblotting. RESULTS:Exercise improved cardiac function in CHF Tr animals. Cardiomyocytes from CHF Sed rats were more susceptible to oxidative stress-induced cell death than CHF Tr and Sham cardiomyocytes, with glibenclamide completely abolishing the protective effect of exercise. Glibenclamide did not affect cardiomyocyte survival in Sham or CHF Sed rats. In addition, exercise increased the systolic Ca²⁺ transient amplitude and improved diastolic Ca²⁺ removal in CHF Tr cardiomyocytes (compared with CHF Sed); both were significantly attenuated by glibenclamide. Exercise resulted in increased expression of KATP channel subunits in CHF Tr hearts, with more pronounced and significant effect on SUR2A. CONCLUSIONS:Our data suggest that KATP channel upregulation induced by chronic exercise likely mediates some of exercise-induced beneficial effects on cardiac function in postischemic heart failure.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Kraljevic J,Høydal MA,Ljubkovic M,Moreira JB,Jørgensen K,Ness HO,Bækkerud FH,Dujic Z,Wisløff U,Marinovic Jdoi
10.1249/MSS.0000000000000714subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2504-12issue
12eissn
0195-9131issn
1530-0315journal_volume
47pub_type
杂志文章abstract::The close balance between the O2 requirement to perform exercise and the O2 supply was analyzed. A non-uniform capillary PO2 can result in anaerobic metabolism in some muscle fibers despite an apparently adequate mean capillary PO2. The pattern of lactate increase for constant work rates and incremental exercise is de...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198606000-00017
更新日期:1986-06-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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更新日期:2016-01-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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更新日期:2006-08-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199707001-00005
更新日期:1997-07-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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更新日期:2007-09-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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doi:10.1249/MSS.0b013e318285c6b6
更新日期:2013-07-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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更新日期:1997-03-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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doi:10.1249/MSS.0b013e318191259c
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-02-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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更新日期:2020-12-23 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:2020-11-07 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/00005768-198204000-00010
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:To determine the prevalence of full-thickness focal chondral defects in the athlete's knee. METHODS:We conducted a systematic review of multiple databases, evaluating studies of the prevalence of articular cartilage defects in athletes. Because of the heterogeneity of data, a meta-analysis could not be perform...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00