Abstract：
PURPOSE:Muscle injury is the most common sports injury. Muscle stiffness, a risk factor for muscle injury, is lower in females than in males, implying that sex-related genetic polymorphisms influence muscle injury associated with muscle stiffness. The present study aimed to clarify the associations between two genetic polymorphisms (rs2234693 and rs9340799) in the estrogen receptor 1 gene (ESR1) and muscle injury or muscle stiffness. METHODS:In study 1, a questionnaire was used to assess the muscle injury history of 1311 Japanese top-level athletes. In study 2, stiffness of the hamstring muscles was assessed using ultrasound shear wave elastography in 261 physically active young adults. In both studies, rs2234693 C/T and rs9340799 G/A polymorphisms in the ESR1 were analyzed using the TaqMan SNP Genotyping Assay. RESULTS:In study 1, genotype frequencies for ESR1 rs2234693 C/T were significantly different between the injured and noninjured groups in a C-allele dominant (CC + CT vs TT: odds ratio, 0.62; 95% confidence interval, 0.43-0.91) and additive (CC vs CT vs TT: odds ratio, 0.70; 95% confidence interval, 0.53-0.91) model in all athletes. In study 2, hamstring muscle stiffness was lower in subjects with the CC + CT genotype than in those with the TT genotype; a significant linear trend (CC < CT < TT) was found (r = 0.135, P = 0.029). In contrast, no associations were observed between ESR1 rs9340799 G/A and muscle injury or stiffness. CONCLUSIONS:Our results suggest that the ESR1 rs2234693 C allele, in contrast to the T allele, provides protection against muscle injury by lowering muscle stiffness.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Kumagai H,Miyamoto-Mikami E,Hirata K,Kikuchi N,Kamiya N,Hoshikawa S,Zempo H,Naito H,Miyamoto N,Fuku Ndoi
10.1249/MSS.0000000000001750subject
Has Abstractpub_date
2019-01-01 00:00:00pages
19-26issue
1eissn
0195-9131issn
1530-0315journal_volume
51pub_type
杂志文章abstract：:This article focuses on sports related spinal cord and nerve injuries, ranging from mild "stinger" syndrome to complete quadriplegia. Particular emphasis is placed on recommendations for return to competition after such injuries. Cervical spinal cord symptoms after a spine injury from contact sports require a more pre...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199707001-00005
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:To validate the 7-d Physical Activity Recall (PAR) telephone interview version and its activity intensity categories. METHODS:Seventy-four adults (47 women, 27 men), ranging in age (18-67) and activity levels, were interviewed by phone and in-person using the same PAR protocol. Each participant wore a TriTrac-...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.MSS.0000064941.43869.4E
更新日期：2003-05-01 00:00:00
abstract：:During the past three to four decades, a significant amount of data was collected to reinforce the notion that mitochondrial function is irrevocably linked to mitochondrial structure. Indeed, data from numerous studies have revealed several salient points of mitochondrial biology that include the following: 1). mitoch...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：10.1097/00005768-200301000-00014
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION/PURPOSE:Evidence suggests that carbohydrate and protein (CHO-PRO) ingestion after exercise enhances muscle glycogen repletion to a greater extent than carbohydrate (CHO) alone. However, there is no consensus at this point, and results across studies are mixed, which may be attributable to differences in en...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002476
更新日期：2021-02-01 00:00:00
abstract：:The effects of endurance training on aerobic power, and the relationship between aerobic power and running performance were investigated in 11 junior runners over a period of 5-to-7 years, starting from the age of 14. Aerobic power was measured using treadmill running and a protocol that involved increasing speed. The...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Endocrine effects of self-administration of high doses of anabolic steroids and testosterone were investigated in five power athletes during 26 wk of training, and for the following 12-16 wk after drug withdrawal. After 26 wk of anabolic steroid and testosterone administration, serum testosterone concentrations had in...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1985-06-01 00:00:00
abstract：:Nine male and five female college students were tested on four occasions to determine the effects of various exhaustive weightlifting stimuli on forearm blood flow as measured by strain-gauge plethysmography. Maximum voluntary dynamic wrist curl strength was determined in the first session, which was followed by rando...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：INTRODUCTION & PURPOSE:Obesity-related increases of weight on the chest wall are known to decrease lung volume and chest wall compliance, but the effect of this mass loading, independent of other obesity-related complications on the ventilatory response to exercise is unknown. The purpose of this study was to investiga...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000126386.12402.f5
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. METHODS:Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, pla...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1097/00005768-200007000-00001
更新日期：2000-07-01 00:00:00
abstract：:Twelve 9- to 12-year-old children (6 boys, 6 girls) performed four exercise-in-heat (35 degrees C, 45% RH) trials which differed in the composition of the fluids they drank. In each trial, subjects cycled for one 20-min and two 15-min bouts at 50% peak VO2 with 10-min rest periods in between. In a fourth bout, they cy...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：PURPOSE:Above a given exercise intensity, rapid muscle fatigue will occur. We explored the possibility of assessing torque threshold for peripheral fatigue during single-legged repetitive isometric knee extensor exercise. We hypothesized this fatigue threshold to be related to the general aerobic fitness level and the ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318249d701
更新日期：2012-07-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181ebedf4
更新日期：2011-02-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000000631
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:The effect of exercise on body mass is likely to be partially mediated through changes in appetite control. However, no studies have examined the effect of chronic exercise on obestatin and cholecystokinin (CCK) plasma concentrations or the sensitivity to detect differences in preload energy in obese individual...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0b013e31827d1618
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:Increased serum testosterone (TST) occurs in response to resistance exercise and is associated with increased muscle mass. However, the effects of elevated TST and sequential resistance exercise bouts on androgen receptor (AR) expression in humans are not well known. This study examined three sequential bouts o...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1249/01.mss.0000139795.83030.d1
更新日期：2004-09-01 00:00:00
abstract：:Nine men participated in an exercise program (five days a week for 10 weeks) that was designed to strengthen the quadriceps muscles. This study was undertaken to determine if heavy resistance training results in an increase in endurance, Vo2max and whether the differences that are normally observed during bicycle and ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:Changes in body composition, fat distribution and lipoprotein lipids in response to weight loss elicited by a 10-month program of hypocaloric diet (HD) therapy alone or combined with aerobic exercise training (AEX+HD) were examined in sedentary obese older males. Body composition was assessed by hydrodensitometry and ...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：:We examined whether the relation between of ratings of perceived exertion (RPE) and exercise intensities associated with the lactate threshold (LT) and blood lactate concentrations (BLC) of 2.5 and 4.0 mM, established with an incremental protocol, held during 30-min treadmill run at constant velocity (V). RPE (11.6, 1...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199406000-00021
更新日期：1994-06-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：10.1097/00005768-200206000-00007
更新日期：2002-06-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-200212000-00013
更新日期：2002-12-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1097/00005768-199804000-00016
更新日期：1998-04-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Ten subjects were studied to determine within-subject variance (Swi2), and its components, biovariability (Si2) and technological error (Se2) of residual lung volume (RLV). Each subject's RLV was determined 18 times using the oxygen dilution method (O2D) over a 5-day period. Se2 was measured using a 9.0 l spirometer a...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000001100
更新日期：2017-02-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:The aim of this study was to determine the energy expenditure of a 1-h noncontact boxing training session and to compare these results with the energy expenditure of a more conventional recreational activity such as running. Eight healthy males, accustomed to noncontact boxing training, were recruited for the study. S...
journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-12-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0000000000002234
更新日期：2020-05-01 00:00:00
abstract：INTRODUCTION/PURPOSE:Cycling is associated with a reproducible systolic anterograde and diastolic retrograde flow pattern in the brachial artery (BA) of the inactive upper limb, which results in endothelial nitric oxide (NO) release. The purpose of this study was to examine the impact of different types and intensities...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
abstract：:The purpose of this study was to extend our knowledge of running related injuries by determining whether relationships exist between selected anthropometric, biomechanical, muscular strength and endurance, and training variables and runners afflicted with patellofemoral pain (PFP). Specifically, the objectives of this...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
