Abstract:
INTRODUCTION:Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome. METHODS:Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training. RESULTS:Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V·O 2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not different after training. Training induced a shift in muscle fiber composition in both groups but in opposite directions. The proportion of type 2× fibers decreased with a concomitant increase in type 2a mixed fibers in the control subjects, but in metabolic syndrome, type 2× fiber proportion increased and type 1 fibers decreased. Muscle fiber diameters increased in all three fiber types in metabolic syndrome subjects. Muscle insulin receptor expression increased in both groups, and GLUT4 expression increased in the metabolic syndrome subjects. The excess phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser337 in metabolic syndrome muscle tended to increase further after training in spite of a decrease in total IRS-1. CONCLUSIONS:In the absence of weight loss, the cycle training of metabolic syndrome subjects resulted in enhanced mitochondrial biogenesis and increased the expression of insulin receptors and GLUT4 in muscle but did not decrease the insulin resistance. The failure for the insulin signal to proceed past IRS-1 tyrosine phosphorylation may be related to excess serine phosphorylation at IRS-1 Ser337, and this is not ameliorated by 8 wk of endurance exercise training.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Stuart CA,South MA,Lee ML,McCurry MP,Howell ME,Ramsey MW,Stone MHdoi
10.1249/MSS.0b013e31829a6ce8subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2021-9issue
11eissn
0195-9131issn
1530-0315journal_volume
45pub_type
杂志文章abstract:PURPOSE:The present study assessed the factorial validity and gender invariance of the Social Physique Anxiety Scale (SPAS) using a sample of young adolescents. Existing SPAS 12-item, one- and two-factor and truncated, one-factor (i.e., nine-item and seven-item) measurement models reported in the adult literature were ...
journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318285c6b6
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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doi:
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31819012bd
更新日期:2009-04-01 00:00:00
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journal_title:Medicine and science in sports and exercise
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journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
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journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
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journal_title:Medicine and science in sports and exercise
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