Abstract:
PURPOSE:High-throughput profiling of metabolic status (metabolomics) allows for the assessment of small-molecule metabolites that may participate in exercise-induced biochemical pathways and corresponding cardiometabolic risk modification. We sought to describe the changes in a diverse set of plasma metabolite profiles in patients undergoing chronic exercise training and assess the relationship between metabolites and cardiometabolic response to exercise. METHODS:A secondary analysis was performed in 216 middle-age abdominally obese men and women (mean ± SD, 52.4 ± 8.0 yr) randomized into one of four groups varying in exercise amount and intensity for 6-month duration: high amount high intensity, high amount low intensity, low amount low intensity, and control. One hundred forty-seven metabolites were profiled by liquid chromatography-tandem mass spectrometry. RESULTS:No significant differences in metabolite changes between specific exercise groups were observed; therefore, subsequent analyses were collapsed across exercise groups. There were no significant differences in metabolite changes between the exercise and control groups after 24 wk at a Bonferroni-adjusted statistical significance (P < 3.0 × 10). Seven metabolites changed in the exercise group compared with the control group at P < 0.05. Changes in several metabolites from distinct metabolic pathways were associated with change in cardiometabolic risk traits, and three baseline metabolite levels predicted changes in cardiometabolic risk traits. CONCLUSIONS:Metabolomic profiling revealed no significant plasma metabolite changes between exercise and control after 24 wk at Bonferroni significance. However, we identified circulating biomarkers that were predictive or reflective of improvements in cardiometabolic traits in the exercise group.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Brennan AM,Benson M,Morningstar J,Herzig M,Robbins J,Gerszten RE,Ross Rdoi
10.1249/MSS.0000000000001594subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1480-1486issue
7eissn
0195-9131issn
1530-0315journal_volume
50pub_type
杂志文章,随机对照试验abstract:UNLABELLED:Physically active classroom lessons have been found to increase on-task behavior in children. Given that physical activity has been associated with an increased time on task (TOT) and that overweight children take fewer steps than normal weight children do, it was expected that benefits of the physical activ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181a61495
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:High-intensity endurance training can elicit profound cardiac adaptations; however, the current evidence as to its impact on the proximal aorta is limited. The purpose of this study was to investigate the morphological and functional characteristics of the proximal aorta in endurance athletes. METHODS:Fif...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002508
更新日期:2020-08-31 00:00:00
abstract:PURPOSE:The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whet...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200008000-00012
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:To evaluate the effects of a 12-wk period of aquatic training and subsequent detraining on health-related quality of life (HRQOL) and physical fitness in females with fibromyalgia. METHODS:Thirty-four females with fibromyalgia were randomly assigned into two groups: an exercise group, who exercised for 60 min ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/01.mss.0b0138059aec4
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:This study examines heavy episodic alcohol consumption and associated harms in collegiate athletes in the United States. The factors which may promote or deter such use are explored. METHODS:Randomly selected students in a nationally representative sample of 4-yr colleges in the United States completed self-re...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200101000-00008
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to test the hypothesis that intermittent hypoxic interval training improves sea level cycling performance more than equivalent training in hypoxia or normoxia. METHODS:Thirty-three well-trained cyclists and triathletes (25.9 +/- 2.7 yr, VO(2max) 66.1 +/- 6.1 mL.min(-1).kg(-1)) were di...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.mss.0000150077.30672.88
更新日期:2005-01-01 00:00:00
abstract::Red blood cells obtained from well-trained athletes consumed glucose at a higher rate than those from sedentary subjects when incubated in vitro in a glucose containing medium at 37 degrees C. Similar results were obtained when fructose was substituted for glucose, but not when galactose was the monosaccharide. The ut...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Light-intensity physical activity (LIPA) accounts for much of adults' waking hours (≈40%) and substantially contributes to overall daily energy expenditure. Encompassing activity behaviors of low intensity (standing with little movement) to those of higher intensity (slow walking), LIPA is ubiquitous, yet littl...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000631
更新日期:2015-10-01 00:00:00
abstract::A variety of physiological responses, classified as local or central factors, have been suggested as providing the primary input for perception of effort during exercise. The potency of these responses as perceptual cues, however, has seldom been addressed in terms of relevant modifying variables such as exercise inte...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Because physical activity researchers are increasingly using objective portable devices, this review describes the current state of the technology to assess physical activity, with a focus on specific sensors and sensor properties currently used in monitors and their strengths and weaknesses. Additional sens...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1249/MSS.0b013e3182399bc8
更新日期:2012-01-01 00:00:00
abstract::The papers in this supplement to Medicine and Science in Sports and Exercise seek to summarize our knowledge of the dose-response relationship of exercise with a variety of health outcomes. This type of rigorous evidence summation has become quite popular in the past 10 years as health care providers and policymakers ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200106001-00004
更新日期:2001-06-01 00:00:00
abstract::A group of 103 female weight lifters (WL) and 92 control (C) women answered a survey concerning eating behavior and attitudes (including the Eating Disorder Inventory) and menstrual function. The incidence of menstrual dysfunction, defined as oligomenorrhea plus amenorrhea, was significantly higher for the WL (30%) th...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The development of valid measures of built environments relevant for physical activity is an important step toward controlling the global epidemic of physical inactivity-related noncommunicable diseases and deaths. This study assessed the construct validity of a self-report neighborhood environment walkability ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001131
更新日期:2017-03-01 00:00:00
abstract:INTRODUCTION:The SenseWear Pro Armband (SWA) has been shown to be a valid and practical tool to assess energy expenditure (EE) in adults. However, recent studies have reported significant errors in EE estimates when the algorithms are applied to children. The purpose of this study was to assess the validity of recently...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181a071cf
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Maximizing carbohydrate availability is important for many endurance events. Combining pectin and sodium alginate with ingested maltodextrin-fructose (MAL + FRU + PEC + ALG) has been suggested to enhance carbohydrate delivery via hydrogel formation, but the influence on exogenous carbohydrate oxidation remains ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000002262
更新日期:2020-06-01 00:00:00
abstract::Motivation to engage in health-promoting exercise has been ascribed to global personality traits such as self-esteem or athletic self-confidence. Self-Efficacy Theory challenges this view by proposing that highly specific estimates of personal capabilities mediate adoption of new or difficult behavior patterns. We tes...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract:PURPOSE:Elevated rates of cardiometabolic diseases have been observed in former American football players. The current study sought to determine whether change in body mass index (ΔBMI) after retirement influences the prevalence of CHD, diabetes, or high blood pressure (HBP) in former professional football players. ME...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001492
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Lateral compartment osteoarthritis accompanied by abnormal knee biomechanics is frequently reported in individuals with knee osteoarthritis after anterior cruciate ligament reconstruction (ACLR). The aim of this study was to evaluate changes in knee biomechanics produced by an adjusted and unadjusted varus knee...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001201
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:The purpose of this paper was to determine whether differences in hemoglobin (Hb) and muscle aerobic capacity exist between African-American (AA) and Caucasian (CA) premenopausal women and to determine whether Hb and aerobic capacity of the muscle are associated with the racial differences in maximum oxygen upt...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200110000-00019
更新日期:2001-10-01 00:00:00
abstract:PURPOSE:This study aimed to analyze the influence of foot strike pattern on running economy and biomechanical characteristics in subelite runners with a similar performance level. METHODS:Twenty subelite long-distance runners participated and were divided into two groups according to their foot strike pattern: rearfoo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000139
更新日期:2014-03-01 00:00:00
abstract::Selective beta 1-receptor blockade with atenolol (1 mg X kg-1, i.v.) was used to determine the effect of partial exercise training on diastolic coronary resistance (DCR) during sub-maximal exercise. Seven conscious dogs were studied in the untrained (UT) and partially trained (PT) conditions. The conditioning regime c...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract:UNLABELLED:Cell-derived procoagulant microparticles (MP) might be able to contribute to exercise-induced changes in blood hemostasis. PURPOSES:This study aimed to examine (i) the concentration and procoagulant activity of cell-derived MP after a moderate endurance exercise and (ii) the differences in the release, clea...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0b013e3182068645
更新日期:2011-07-01 00:00:00
abstract::The effects of steady state exercise on the power spectrum of heart rate variability were studied in 19 healthy subjects. Continuous ECG signals were recorded during 1) 15 min of rest in the supine state, 2) 10 min of standing, 3) 10 min of steady state exercise at 50% of maximum predicted power output on a cycle ergo...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:INTRODUCTION:This study determines Chinese body segment parameters based on a magnetic resonance imaging method. METHODS:Fifty young Chinese men (21.5 ± 1.52 yr) participated in this study. Magnetic resonance images were obtained using a GE magnetic resonance imaging 1.5-T scanner with 10-mm thickness. The magnetic re...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182923b2a
更新日期:2013-09-01 00:00:00
abstract::Increased vertical impact loading during running has been associated with a variety of running related injuries including stress fractures, patellofemoral pain, and plantar fasciitis. PURPOSE:The purpose of this study was to examine the acute and long-term effect of a gait retraining program aimed at teaching runners...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001710
更新日期:2018-12-01 00:00:00
abstract:INTRODUCTION/PURPOSE:Cycling is associated with a reproducible systolic anterograde and diastolic retrograde flow pattern in the brachial artery (BA) of the inactive upper limb, which results in endothelial nitric oxide (NO) release. The purpose of this study was to examine the impact of different types and intensities...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181923957
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:This study investigated the kinetic and the kinematic differences in female athletes in single-leg static jumps in an aquatic environment compared with those performed on dry land. METHODS:Twelve healthy, junior national team handball players participated. Subjects completed a familiarization and a testing ses...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3181a252b7
更新日期:2009-09-01 00:00:00
abstract::The purpose was to study the effects of skipping rate on energy expenditure and sex differences in response to rope skipping. Responses of 19 males and 11 females were measured while skipping for 5 min at 125, 135 and 145 skips . min-1. Expired air was routed through a hollow handle to collection bags to provide unint...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::The uptake of zinc (Zn) into the plasma after the ingestion of 25 mg of Zn from multivitamin-mineral supplement was studied in 10 men during running (R) and control (C) conditions; the R was for 2 h at 60-65% of their maximal oxygen uptake. Subjects took the supplement with 200 ml of deionized water before the R or C ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract:PURPOSE:To compare the cardiovascular reactivity response to mental challenge of aerobically trained and untrained preadolescent boys. METHODS:Heart rate (HR) and blood pressure, as well as stroke volume, total peripheral resistance, rate pressure product, and cardiac contractility response in 15 aerobically trained (...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/01.MSS.0000078935.78895.8E
更新日期:2003-08-01 00:00:00