An unusual cause of bruising in an 80-year-old woman.

Abstract:

PRESENTATION:a previously fit 80-year-old woman presented with a 2-week history of spontaneous and extensive bruising affecting all four limbs. The severity was such that she required a transfusion of 8 units of blood. RESULTS OF INVESTIGATIONS:a markedly prolonged activated partial thromboplastin time which was only partially corrected with normal plasma; tests for lupus anticoagulant were negative. Factor VIII levels were reduced and the Bethesda assay indicated an acquired inhibitor to factor VIII. She was treated with a combination of intravenous immunoglobulin and immunosuppression. OUTCOME:the response to treatment was excellent, with a marked reduction in anti-factor VIII antibody levels and resolution of the bruising over the next few weeks.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Kelly J,Gattens M,Geraghty R

doi

10.1093/ageing/29.3.261

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

261-3

issue

3

eissn

0002-0729

issn

1468-2834

journal_volume

29

pub_type

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