Abstract:
PRESENTATION:a previously fit 80-year-old woman presented with a 2-week history of spontaneous and extensive bruising affecting all four limbs. The severity was such that she required a transfusion of 8 units of blood. RESULTS OF INVESTIGATIONS:a markedly prolonged activated partial thromboplastin time which was only partially corrected with normal plasma; tests for lupus anticoagulant were negative. Factor VIII levels were reduced and the Bethesda assay indicated an acquired inhibitor to factor VIII. She was treated with a combination of intravenous immunoglobulin and immunosuppression. OUTCOME:the response to treatment was excellent, with a marked reduction in anti-factor VIII antibody levels and resolution of the bruising over the next few weeks.
journal_name
Age Ageingjournal_title
Age and ageingauthors
Kelly J,Gattens M,Geraghty Rdoi
10.1093/ageing/29.3.261subject
Has Abstractpub_date
2000-05-01 00:00:00pages
261-3issue
3eissn
0002-0729issn
1468-2834journal_volume
29pub_type
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