Abstract：
:Cytolytic T-cell responses from 63 normal blood donors were monitored in a Mycobacterium bovis BCG infection system in vitro. We wanted to know whether cultured dendritic cells were capable of potentiating the cytolytic T-cell responses to M. bovis BCG. Infected cultured dendritic cells were up to ten times more effective antigen-presenting cells than macrophages in proliferative assays, while cytolytic T-cell induction did not differ significantly between dendritic cells and macrophages. Separated CD4+ and CD8+ T-cell subsets contributed equally to lysis of infected targets. Experiments comparing wild-type M. bovis BCG strain with two new recombinant M. bovis BCG strains secreting listeriolysin revealed statistically significant higher maximal lysis values for recombinant M. bovis BCG. We conclude from our in vitro infection system with mycobacteria that dendritic cells are superior to macrophages in proliferative assays but equal to macrophages in their ability to induce cytolytic T-cell responses. Moreover, our data suggest that recombinant M. bovis BCG vaccine strains secreting listeriolysin improve cytolytic T-cell responses.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Conradt P,Hess J,Kaufmann SHdoi
10.1016/s1286-4579(99)80077-xsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
753-64issue
10eissn
1286-4579issn
1769-714Xpii
S1286-4579(99)80077-Xjournal_volume
1pub_type
杂志文章abstract：:The mechanisms and molecular effectors of pathogen recognition systems in diverse hosts are highly conserved. Both plant and animal recognition of pathogens relies on sensing of Pathogen-Associated Molecular Patterns (PAMPs) by Pattern Recognition Molecules (PRMs). To detect bacteria, these sensor molecules can recogn...
journal_title：Microbes and infection
pub_type： 杂志文章,评审
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abstract：:Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an onco...
journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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abstract：:In this report, we examined the genetic diversity of HIV-1 strains circulating in the city of Beira, the second largest metropolitan area in Mozambique. A total of 131 blood samples, collected between August and October 2003 from antiretroviral-naïve individuals, were characterized with a combined approach consisting ...
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：1999-07-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
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更新日期：2011-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2005.07.006
更新日期：2006-02-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2004.01.009
更新日期：2004-04-01 00:00:00
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journal_title：Microbes and infection
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doi：10.1016/j.micinf.2006.01.001
更新日期：2006-05-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章,评审
doi：10.1016/j.micinf.2009.08.012
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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journal_title：Microbes and infection
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更新日期：2010-08-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：Microbes and infection
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更新日期：2016-02-01 00:00:00
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journal_title：Microbes and infection
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journal_title：Microbes and infection
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更新日期：2007-09-01 00:00:00
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journal_title：Microbes and infection
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:In refractory mosquitoes, melanotic encapsulation of Plasmodium ookinetes and oocysts is a commonly observed immune response. However, in susceptible mosquitoes, Plasmodium oocysts develop extracellularly in the body cavity without being recognized by the immune system. Like Plasmodium gallinaceum oocysts, negatively ...
journal_title：Microbes and infection
pub_type： 杂志文章
doi：10.1016/j.micinf.2006.11.006
更新日期：2007-02-01 00:00:00
