Fluorescence decay time distribution analysis of cyclic enkephalin analogues. Influence of the solvents and configuration of amino acids in position 2 and 3 on changes in conformation.

Abstract:

:The lifetime distribution calculations were applied to study the influence of configuration of amino-acid residues in positions 2 and 3 on changes in conformation of the peptide chain of cyclic analogues of enkephalins containing a fluorescence energy donor and acceptor in different solvents. In all the solvents studied the lifetime distributions were bimodal. This testified to the presence of two families of conformations. In this paper the relationship between the population of each conformation and configuration of the residues in position 2 and 3, and the solvent used is discussed.

journal_name

Acta Biochim Pol

journal_title

Acta biochimica Polonica

authors

Malicka J,Groth M,Czaplewski C,Liwo A,Wiczk W

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

615-29

issue

3

eissn

0001-527X

issn

1734-154X

journal_volume

46

pub_type

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