当前位置： SCI文献检索 > MOLECULAR CELL期刊下所有文献 > Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes.

Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes.

Abstract：

:The L. monocytogenes protein lnlB activates phosphoinositide 3-kinase and induces phagocytosis in several mammalian cell types. The 1.86 A resolution X-ray crystal structure of the leucine-rich repeat domain of lnlB that is both necessary and sufficient to induce phagocytosis is presented here. The structure supports a crucial role for calcium in host cell invasion by L. monocytogenes and supplies a rationale for its function. Calciums are bound to the protein in an unusually exposed manner that suggests that the metals may act as a bridge between lnlB and mammalian cell surface receptors. The structure also identifies surfaces on the curved and elongated molecule that may constitute additional interaction sites in forming a bacterial-mammalian signaling complex.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Marino M,Braun L,Cossart P,Ghosh P

doi

10.1016/s1097-2765(00)80234-8

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1063-72

issue

6

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(00)80234-8

journal_volume

4

pub_type

杂志文章

相关文献

MOLECULAR CELL文献大全
  • ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.

    abstract：:Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation. They are induced by various stress conditions, including exposure to the environmental toxin and carcinogen arsenic. While perturbed SG turnover is linked to the pathogenesis of neurodegenerative diseases, the molecular mechan...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2018.04.021

    authors： Turakhiya A,Meyer SR,Marincola G,Böhm S,Vanselow JT,Schlosser A,Hofmann K,Buchberger A

    更新日期：2018-06-07 00:00:00

  • Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29.

    abstract：:The DNA polymerase from phage phi29 is a B family polymerase that initiates replication using a protein as a primer, attaching the first nucleotide of the phage genome to the hydroxyl of a specific serine of the priming protein. The crystal structure of phi29 DNA polymerase determined at 2.2 A resolution provides expl...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2004.10.019

    authors： Kamtekar S,Berman AJ,Wang J,Lázaro JM,de Vega M,Blanco L,Salas M,Steitz TA

    更新日期：2004-11-19 00:00:00

  • miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.

    abstract：:Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched in the Argonaute/miR-182 complex and miR-182 downregulates BRCA1 expression. Antagonizing miR-182 enhances BRCA1 protein l...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2010.12.005

    authors： Moskwa P,Buffa FM,Pan Y,Panchakshari R,Gottipati P,Muschel RJ,Beech J,Kulshrestha R,Abdelmohsen K,Weinstock DM,Gorospe M,Harris AL,Helleday T,Chowdhury D

    更新日期：2011-01-21 00:00:00

  • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

    abstract：:The protein kinase B-RAF is mutated in approximately 7% of human cancers. Most mutations are activating, but, surprisingly, a small number have reduced kinase activity. However, the latter can still stimulate cellular signaling through the MEK-ERK pathway because they activate the related family member C-RAF. We exami...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2005.10.022

    authors： Garnett MJ,Rana S,Paterson H,Barford D,Marais R

    更新日期：2005-12-22 00:00:00

  • Opposing Functions of BRD4 Isoforms in Breast Cancer.

    abstract：:Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role of BRD4 in cancer has been attributed mainly to the abundant long isoform (BRD4-L). Here we show, by isoform-specific knockdown and endogenous protein d...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2020.04.034

    authors： Wu SY,Lee CF,Lai HT,Yu CT,Lee JE,Zuo H,Tsai SY,Tsai MJ,Ge K,Wan Y,Chiang CM

    更新日期：2020-06-18 00:00:00

  • Yeast origins establish a strand bias for replicational mutagenesis.

    abstract：:To determine whether replicational mutagenesis in the yeast genome is influenced by the positions of active origins, a reporter gene was placed in two orientations at multiple locations within a 39,000 bp region of chromosome III possessing two strong origins. The frequency of mutations resulting from misincorporation...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(02)00567-1

    authors： Pavlov YI,Newlon CS,Kunkel TA

    更新日期：2002-07-01 00:00:00

  • A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs.

    abstract：:Metazoan histone mRNAs are unique: their pre-mRNAs contain no introns, and the mRNAs are not polyadenylated, ending instead in a conserved stem-loop structure. In Drosophila, canonical poly(A) signals are located downstream of the normal cleavage site of each histone gene and are utilized when histone 3' end formation...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.04.024

    authors： Sullivan KD,Steiniger M,Marzluff WF

    更新日期：2009-05-15 00:00:00

  • Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection.

    abstract：:The RSC chromatin remodeler slides and ejects nucleosomes, utilizing a catalytic subunit (Sth1) with DNA translocation activity, which can pump DNA around the nucleosome. A central question is whether and how DNA translocation is regulated to achieve sliding versus ejection. Here, we report the regulation of DNA trans...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2016.03.032

    authors： Clapier CR,Kasten MM,Parnell TJ,Viswanathan R,Szerlong H,Sirinakis G,Zhang Y,Cairns BR

    更新日期：2016-05-05 00:00:00

  • GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.

    abstract：:Transcriptional coregulators, rather than ligand signals, are suspected to confer context and pathway specificity to nuclear receptor signaling, but the identity of such specifying coregulators and the underlying molecular mechanisms remain largely enigmatic. Here we address this issue in metabolic oxysterol receptor ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.05.006

    authors： Jakobsson T,Venteclef N,Toresson G,Damdimopoulos AE,Ehrlund A,Lou X,Sanyal S,Steffensen KR,Gustafsson JA,Treuter E

    更新日期：2009-05-14 00:00:00

  • A conserved domain within Arc1p delivers tRNA to aminoacyl-tRNA synthetases.

    abstract：:Two yeast enzymes that catalyze aminoacylation of tRNAs, MetRS and GluRS, form a complex with the protein Arc1p. We show here that association of Arc1p with MetRS and GluRS is required in vivo for effective recruitment of the corresponding cognate tRNAs within this complex. Arc1p is linked to MetRS and GluRS through i...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(00)80024-6

    authors： Simos G,Sauer A,Fasiolo F,Hurt EC

    更新日期：1998-01-01 00:00:00

  • Mechanism of homology recognition in DNA recombination from dual-molecule experiments.

    abstract：:In E. coli homologous recombination, a filament of RecA protein formed on DNA searches and pairs a homologous sequence within a second DNA molecule with remarkable speed and fidelity. Here, we directly probe the strength of the two-molecule interactions involved in homology search and recognition using dual-molecule m...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.03.029

    authors： De Vlaminck I,van Loenhout MT,Zweifel L,den Blanken J,Hooning K,Hage S,Kerssemakers J,Dekker C

    更新日期：2012-06-08 00:00:00

  • NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

    abstract：:Activating mutations in NOTCH1, an essential regulator of T cell development, are frequently found in human T cell acute lymphoblastic leukemia (T-ALL). Despite important advances in our understanding of Notch signal transduction, the regulation of Notch functions in the nucleus remains unclear. Using immunoaffinity p...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.08.022

    authors： Yatim A,Benne C,Sobhian B,Laurent-Chabalier S,Deas O,Judde JG,Lelievre JD,Levy Y,Benkirane M

    更新日期：2012-11-09 00:00:00

  • Molecular architecture of the human pre-mRNA 3' processing complex.

    abstract：:Pre-mRNA 3' end formation is an essential step in eukaryotic gene expression. Over half of human genes produce alternatively polyadenylated mRNAs, suggesting that regulated polyadenylation is an important mechanism for posttranscriptional gene control. Although a number of mammalian mRNA 3' processing factors have bee...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2008.12.028

    authors： Shi Y,Di Giammartino DC,Taylor D,Sarkeshik A,Rice WJ,Yates JR 3rd,Frank J,Manley JL

    更新日期：2009-02-13 00:00:00

  • Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.

    abstract：:DNA replication is initiated by assembly of the kinase cell division cycle 7 (CDC7) with its regulatory activation subunit, activator of S-phase kinase (ASK), to activate DNA helicase. However, the mechanism underlying regulation of CDC7-ASK complex is unclear. Here, we show that ADP generated from CDC7-mediated MCM p...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2018.09.007

    authors： Li X,Qian X,Jiang H,Xia Y,Zheng Y,Li J,Huang BJ,Fang J,Qian CN,Jiang T,Zeng YX,Lu Z

    更新日期：2018-11-15 00:00:00

  • Systems biology makes it personal.

    abstract：:Systems biology promises to personalize medicine via network-based biomarkers that predict therapeutic effectiveness. Toward this goal, Chang et al. (2009) recently introduced a systems-based approach to break down oncogenic signaling networks into modules that predict the effectiveness of pathway-specific therapeutic...

    journal_title：Molecular cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.molcel.2009.04.004

    authors： Brynildsen MP,Collins JJ

    更新日期：2009-04-24 00:00:00

  • Smad about E2F. TGFbeta repressionof c-Myc via a Smad3/E2F/p107 complex.

    abstract：:Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(02)00584-1

    authors： Kowalik TF

    更新日期：2002-07-01 00:00:00

  • Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

    abstract：:MicroRNAs (miRNAs) inhibit mRNA expression in general by base pairing to the 3'UTR of target mRNAs and consequently inhibiting translation and/or initiating poly(A) tail deadenylation and mRNA destabilization. Here we examine the mechanism and kinetics of miRNA-mediated deadenylation in mouse Krebs-2 ascites extract. ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.08.004

    authors： Fabian MR,Mathonnet G,Sundermeier T,Mathys H,Zipprich JT,Svitkin YV,Rivas F,Jinek M,Wohlschlegel J,Doudna JA,Chen CY,Shyu AB,Yates JR 3rd,Hannon GJ,Filipowicz W,Duchaine TF,Sonenberg N

    更新日期：2009-09-24 00:00:00

  • Ras enhances Myc protein stability.

    abstract：:Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal cell growth control as well as during oncogenesis. We now show that Ras enhances the accumulation of Myc activity by stabilizing the Myc protein. Whereas Myc has a very short half-life when produced in the absence of mitogenic ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(00)80308-1

    authors： Sears R,Leone G,DeGregori J,Nevins JR

    更新日期：1999-02-01 00:00:00

  • Epigenetic Control of Expression Homeostasis during Replication Is Stabilized by the Replication Checkpoint.

    abstract：:DNA replication introduces a dosage imbalance between early and late replicating genes. In budding yeast, buffering gene expression against this imbalance depends on marking replicated DNA by H3K56 acetylation (H3K56ac). Whether additional processes are required for suppressing transcription from H3K56ac-labeled DNA r...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2018.05.015

    authors： Voichek Y,Mittelman K,Gordon Y,Bar-Ziv R,Lifshitz Smit D,Shenhav R,Barkai N

    更新日期：2018-06-21 00:00:00

  • Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

    abstract：:B and T cell receptor gene assembly by V(D)J recombination is tightly regulated during lymphoid development. The mechanisms involved in this regulation are poorly understood. Here we show that nucleosomal DNA is refractory to V(D)J cleavage. However, the presence of HMG1, a chromatin-associated nonhistone DNA-binding ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(00)80297-x

    authors： Kwon J,Imbalzano AN,Matthews A,Oettinger MA

    更新日期：1998-12-01 00:00:00

  • Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation.

    abstract：:MYOD-directed fibroblast trans-differentiation into skeletal muscle provides a unique model to investigate how one transcription factor (TF) reconfigures the three-dimensional chromatin architecture to control gene expression, which is otherwise achieved by the combinatorial activities of multiple TFs. Integrative ana...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2019.07.036

    authors： Dall'Agnese A,Caputo L,Nicoletti C,di Iulio J,Schmitt A,Gatto S,Diao Y,Ye Z,Forcato M,Perera R,Bicciato S,Telenti A,Ren B,Puri PL

    更新日期：2019-11-07 00:00:00

  • Formation of a novel four-helix bundle and molecular recognition sites by dimerization of a response regulator phosphotransferase.

    abstract：:A basis for understanding specificity of molecular recognition between phosphorelay proteins has been deduced from the 2.6 A structure of the Spo0B phosphotransferase of the phosphorelay regulating sporulation initiation. Spo0B consists of two domains: an N-terminal alpha-helical hairpin domain and a C-terminal alpha/...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/s1097-2765(00)80148-3

    authors： Varughese KI,Madhusudan,Zhou XZ,Whiteley JM,Hoch JA

    更新日期：1998-10-01 00:00:00

  • Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.

    abstract：:In all branches of life, stalled translation intermediates are recognized and processed by ribosome-associated quality control (RQC) pathways. RQC begins with the splitting of stalled ribosomes, leaving an unfinished polypeptide still attached to the large subunit. Ancient and conserved NEMF family RQC proteins target...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2020.11.002

    authors： Crowe-McAuliffe C,Takada H,Murina V,Polte C,Kasvandik S,Tenson T,Ignatova Z,Atkinson GC,Wilson DN,Hauryliuk V

    更新日期：2021-01-07 00:00:00

  • Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.

    abstract：:Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity has been largely limited to single domains that preferentially bind to lysine 48-linked polyubiquitin (K48-polyUb) in isolati...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2009.02.011

    authors： Sims JJ,Cohen RE

    更新日期：2009-03-27 00:00:00

  • Hierarchical modularity and the evolution of genetic interactomes across species.

    abstract：:To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.05.028

    authors： Ryan CJ,Roguev A,Patrick K,Xu J,Jahari H,Tong Z,Beltrao P,Shales M,Qu H,Collins SR,Kliegman JI,Jiang L,Kuo D,Tosti E,Kim HS,Edelmann W,Keogh MC,Greene D,Tang C,Cunningham P,Shokat KM,Cagney G,Svensson JP,Gut

    更新日期：2012-06-08 00:00:00

  • PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

    abstract：:K-Ras associates with the plasma membrane (PM) through farnesylation that functions in conjunction with an adjacent polybasic sequence. We show that phosphorylation by protein kinase C (PKC) of S181 within the polybasic region promotes rapid dissociation of K-Ras from the PM and association with intracellular membrane...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2006.01.012

    authors： Bivona TG,Quatela SE,Bodemann BO,Ahearn IM,Soskis MJ,Mor A,Miura J,Wiener HH,Wright L,Saba SG,Yim D,Fein A,Pérez de Castro I,Li C,Thompson CB,Cox AD,Philips MR

    更新日期：2006-02-17 00:00:00

  • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

    abstract：:Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins. These interactions have been considered promiscuous, but our analysis of the affinity of eight BH3 peptides for five Bcl-2-like prote...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2004.12.030

    authors： Chen L,Willis SN,Wei A,Smith BJ,Fletcher JI,Hinds MG,Colman PM,Day CL,Adams JM,Huang DC

    更新日期：2005-02-04 00:00:00

  • From Association to Causality: the Role of the Gut Microbiota and Its Functional Products on Host Metabolism.

    abstract：:Many genomic studies have revealed associations between the gut microbiota composition and host metabolism. These observations led to the idea that a causal relationship could exist between the microbiota and metabolic diseases, a concept supported by studies showing compositional changes in the microbial community in...

    journal_title：Molecular cell

    pub_type： 杂志文章,评审

    doi：10.1016/j.molcel.2020.03.005

    authors： Koh A,Bäckhed F

    更新日期：2020-05-21 00:00:00

  • PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions.

    abstract：:Mitochondrial crista structure partitions vital cellular reactions and is precisely regulated by diverse cellular signals. Here, we show that, in Drosophila, mitochondrial cristae undergo dynamic remodeling among distinct subcellular regions and the Parkinson's disease (PD)-linked Ser/Thr kinase PINK1 participates in ...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2018.01.026

    authors： Tsai PI,Lin CH,Hsieh CH,Papakyrikos AM,Kim MJ,Napolioni V,Schoor C,Couthouis J,Wu RM,Wszolek ZK,Winter D,Greicius MD,Ross OA,Wang X

    更新日期：2018-03-01 00:00:00

  • Reconstitution of an Argonaute-dependent small RNA biogenesis pathway reveals a handover mechanism involving the RNA exosome and the exonuclease QIP.

    abstract：:Argonaute proteins are required for the biogenesis of some small RNAs (sRNAs), including the PIWI-interacting RNAs and some microRNAs. How Argonautes mediate maturation of sRNAs independent of their slicer activity is not clear. The maturation of the Neurospora microRNA-like sRNA, milR-1, requires the Argonaute protei...

    journal_title：Molecular cell

    pub_type： 杂志文章

    doi：10.1016/j.molcel.2012.03.019

    authors： Xue Z,Yuan H,Guo J,Liu Y

    更新日期：2012-05-11 00:00:00