Selective COX-2 inhibitors and human inflammatory bowel disease.

abstract：:Gastro-oesophageal reflux disease (GERD), manifesting with symptoms including heartburn and regurgitation, affects people during both daytime and nocturnal hours. Night-time GERD has been reported to have a greater impact on a patient's life than daytime GERD due to prolonged oesophageal acid exposure time per reflux ...

journal_title：Alimentary pharmacology & therapeutics

authors： Shaker R,Brunton S,Elfant A,Golopol L,Ruoff G,Stanghellini V

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM:To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS:Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean dif...

journal_title：Alimentary pharmacology & therapeutics

authors： Feagan BG,Patel H,Colombel JF,Rubin DT,James A,Mody R,Lasch K

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Infliximab reduces mucosal inflammation in some, but not all, patients with Crohn's disease. AIM:To monitor clinical data and changes in mucosal cytokine levels after infliximab treatment to identify differences between responders and non-responders. METHODS:Twenty-six patients with fistulating Crohn's dis...

journal_title：Alimentary pharmacology & therapeutics

authors： Agnholt J,Dahlerup JF,Buntzen S,Tøttrup A,Nielsen SL,Lundorf E

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Considerable information has been gathered on the functional organization of enteric neuronal circuitries regulating gastrointestinal motility. However, little is known about the neuropathophysiological mechanisms underlying gastrointestinal motor disorders. AIM:To analyse the most important pathological fi...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Nardo G,Blandizzi C,Volta U,Colucci R,Stanghellini V,Barbara G,Del Tacca M,Tonini M,Corinaldesi R,De Giorgio R

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is associated with colorectal neoplasia. Yet, NAFLD ranges from simple steatosis to steatohepatitis with advanced fibrosis. AIM:To investigate the risk of colorectal neoplasia according to the presence and severity of NAFLD. METHODS:A total of 26 540 asymptomatic a...

journal_title：Alimentary pharmacology & therapeutics

authors： Ahn JS,Sinn DH,Min YW,Hong SN,Kim HS,Jung SH,Gu S,Rhee PL,Paik SW,Son HJ,Gwak GY

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. AIM:To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Dickman R,Parthasarathy S,Malagon IB,Jones P,Han B,Powers J,Fass R

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. AIMS:To determine whether circulating microRNAs are reliable biomarkers for IBD monitoring. METHODS:Serum levels of 17 candidate microRNAs were measured by quantitative real-t...

journal_title：Alimentary pharmacology & therapeutics

authors： Chen P,Li Y,Li L,Yu Q,Chao K,Zhou G,Qiu Y,Feng R,Huang S,He Y,Chen B,Chen M,Zeng Z,Zhang S

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:A high proportion of patients with inflammatory bowel disease (IBD) do not achieve clinical remission with the current therapies including mesalazine (mesalamine), immunossupresants (IMS) and antibodies against tumour necrosis factor (anti-TNF). Moreover, IMS and anti-TNF involve a nonnegligible risk for inf...

journal_title：Alimentary pharmacology & therapeutics

authors： Lobatón T,Vermeire S,Van Assche G,Rutgeerts P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The prevalence of coeliac disease (CD) may be increased in individuals with dyspepsia, but evidence is conflicting. AIMS:To conduct a systematic review and meta-analysis of studies reporting prevalence of CD in dyspepsia. METHODS:MEDLINE, EMBASE, and CINAHL were searched up to February 2009. Case series an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ford AC,Ching E,Moayyedi P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:There are conflicting reports on the role of gastro-oesophageal reflux disease (GERD) and Helicobacter pylori infection in the aetiology of carditis. AIM:The role of reflux and H. pylori infection in causing carditis was assessed in 113 consecutive patients with GERD and in 25 controls. METHODS:All subject...

journal_title：Alimentary pharmacology & therapeutics

authors： Zentilin P,Mastracci L,Dulbecco P,Gambaro C,Bilardi C,Ceppa P,Spaggiari P,Iiritano E,Mansi C,Vigneri S,Fiocca R,Savarino V

更新日期：2004-06-15 00:00:00

abstract：:Gastroesophagel reflux disease (GERD) is a common condition encountered in clinical practice. Over the years there has been a continuous interaction between the understanding of the disease, the diagnostic tools and treatments of GERD. The use of proton pump inhibitor (PPI) trials by primary care physicians as diagnos...

journal_title：Alimentary pharmacology & therapeutics

authors： Tutuian R,Castell DO

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM:To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Whitehead WE,Duffy K,Sharpe J,Nabata T,Bruce M

更新日期：2017-01-01 00:00:00

abstract：:Erythromycin is a prokinetic agent for the lower oesophageal sphincter, the stomach, the gallbladder and the small bowel, acting directly on motilin receptors. Its effect on pressure activity of the human colon has not been investigated. Eight healthy volunteers were studied on 2 occasions and given intravenous or ora...

journal_title：Alimentary pharmacology & therapeutics

authors： Jameson JS,Rogers J,Misiewicz JJ,Raimundo AH,Henry MM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:The effects of lactulose and polyethylene glycol on colonic transit are poorly established. AIM:To assess the effects of these laxatives on colonic transit in normal subjects. METHODS:Colonic transit (mean residence time, cumulative counts in stool, counts remaining in the proximal or distal colon) was mea...

journal_title：Alimentary pharmacology & therapeutics

authors： Fritz E,Hammer HF,Lipp RW,Högenauer C,Stauber R,Hammer J

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor α (anti-TNF) agents have been implicated in drug-induced liver injury. There is minimal data on this occurrence in inflammatory bowel disease (IBD) patients. AIM:To identify the characteristics of liver enzyme elevations following anti-TNF therapy initiation in IBD. METHODS:A re...

journal_title：Alimentary pharmacology & therapeutics

authors： Shelton E,Chaudrey K,Sauk J,Khalili H,Masia R,Nguyen DD,Yajnik V,Ananthakrishnan AN

更新日期：2015-05-01 00:00:00

abstract：:Hepatic diseases are common complications of haematopoietic cell transplant. The causes are multiple: myeloablative conditioning regimens may cause sinusoidal injury; acute and chronic graft-versus-host disease lead to damaged hepatocytes and small bile ducts; microcrystalline deposits in the gall bladder can cause bi...

journal_title：Alimentary pharmacology & therapeutics

authors： McDonald GB

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Ranitidine 75 mg (Zantac 75) has been shown to be effective for the treatment of pre-existing heartburn symptoms. AIM:To compare the efficacy of dosing ranitidine 75 mg or placebo 30 min prior to a proven heartburn-provoking meal in completely preventing or reducing subsequent heartburn symptoms. METHODS:A...

journal_title：Alimentary pharmacology & therapeutics

authors： Pappa KA,Williams BO,Payne JE,Buaron KS,Mussari KL,Ciociola AA

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Comparative long-term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) for prevention of disease progression to hepatocellular carcinoma (HCC) among high-risk patients with chronic hepatitis B (CHB)-related compensated cirrhosis is controversial. AIMS:To compare the long-term efficacy of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu TH,Yueh-Hsia Chiu S,Tseng PL,Chen CH,Lu SN,Wang JH,Hung CH,Kee KM,Lin MT,Chang KC,Lin MC,Chien RN

更新日期：2020-12-01 00:00:00

abstract：AIM:To study the effect of prokinetic treatment with cisapride in patients with constipation-predominant irritable bowel syndrome. PATIENTS AND METHODS:Ninety-six patients were randomly assigned to treatment with either cisapride 5 mg three times daily or placebo three times daily for a period of 12 weeks. The dosage ...

journal_title：Alimentary pharmacology & therapeutics

authors： Schütze K,Brandstätter G,Dragosics B,Judmaier G,Hentschel E

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Gastric cancer can be divided into cardia and noncardia gastric adenocarcinoma (NCGA). Non cardia gastric cancer is a disease that has declined in global incidence but has remained as an extremely lethal cancer. AIM:To review recent advances in epidemiology and strategies in prevention of non cardia gastric...

journal_title：Alimentary pharmacology & therapeutics

authors： Fock KM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:The effect of direct-acting anti-virals (DAAs) in children and adolescents with chronic hepatitis C virus (HCV) infection is difficult to determine, since few, aged between 3 and 18 years, have been enrolled in clinical trials, and some data come from observational studies. AIM:To summarise the evidence on ...

journal_title：Alimentary pharmacology & therapeutics

authors： Indolfi G,Giometto S,Serranti D,Bettiol A,Bigagli E,De Masi S,Lucenteforte E

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Bodybuilding supplements can cause a profound cholestatic syndrome. AIM:To describe the drug-Induced liver injury network's experience with liver injury due to bodybuilding supplements. METHODS:Liver injury pattern, severity and outcomes, potential genetic associations, and exposure to anabolic steroids by...

journal_title：Alimentary pharmacology & therapeutics

authors： Stolz A,Navarro V,Hayashi PH,Fontana RJ,Barnhart HX,Gu J,Chalasani NP,Vega MM,Bonkovsky HL,Seeff LB,Serrano J,Avula B,Khan IA,Cirulli ET,Kleiner DE,Hoofnagle JH,DILIN Investigators.

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:In behavioural economics, a 'nudge' describes configuration of a choice to encourage a certain action without taking away freedom of choice. AIM:To determine the impact of a 'nudge' strategy - prefilling either 3mL or 5mL syringes with midazolam - on endoscopic sedation practice. METHODS:Consecutive patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Harewood GC,Clancy K,Engela J,Abdulrahim M,Lohan K,O'Reilly C

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Unable to resolve a medical problem, gastroenterologists occasionally choose an ineffectual intervention instead. The elusive path to effectual management becomes substituted with an ineffectual but readily available medical ritual. The term 'ritual' refers to the utilization of an ineffectual intervention w...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2004-11-01 00:00:00

abstract：:The risk of colorectal cancer for any patient with ulcerative colitis is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. The relative risk of colorectal cancer in Crohn's colitis is approximately 5.6 and should raise the same concerns as in ulcerative colitis. Risk factors for c...

journal_title：Alimentary pharmacology & therapeutics

authors： Eaden J

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:A lack of reliable treatments for abdominal pain-related functional gastrointestinal disorders prompts interest in new therapies. AIM:To evaluate systematically the effect of Lactobacillus rhamnosus GG (LGG) for treating abdominal pain-related functional gastrointestinal disorders in children. METHODS:MEDL...

journal_title：Alimentary pharmacology & therapeutics

authors： Horvath A,Dziechciarz P,Szajewska H

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:While current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is often times attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Szeinbach SL,Baran RW,Dietz B,Gazzouola Rocca L,Littlefield D,Yawn BP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Fibroblast growth factors play an important role in (patho)physiological processes such as wound healing and tissue repair. We previously showed that basic fibroblast growth factor is actively involved in inflammatory bowel disease processes. In the present retrospective study, we assessed whether serum basi...

journal_title：Alimentary pharmacology & therapeutics

authors： Gao Q,Hogezand RA,Lamers CB,Verspaget HW

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed. AIM:To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS:We recorded t...

journal_title：Alimentary pharmacology & therapeutics

authors： Taha AS,Angerson WJ,Prasad R,McCloskey C,Gilmour D,Morran CG

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Functional dyspepsia is a problem that is difficult to treat in clinical practice. AIM:To evaluate the efficacy and safety of rebamipide (a cytoprotective drug) in functional dyspepsia. METHODS:Patients with functional dyspepsia (n=557) were divided a priori into two studies by Helicobacter pylori status, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Talley NJ,Riff DS,Schwartz H,Marcuard SP

更新日期：2001-10-01 00:00:00