Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome.

abstract：BACKGROUND:The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. AIM:The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicilli...

journal_title：Alimentary pharmacology & therapeutics

authors： Ortiz RA,Calafatti SA,Corazzi A,Souza JM,Deguer M,De Souza CA,Marchioretto MA,Bernasconi G,Ferraz JG,Pedrazzoli J Jr

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Strong suppression of viral replication and normalization of alanine aminotransferase is feasible with nucleos(t)ide analogues. It is estimated viral replication and liver inflammation can be controlled in 90% of patients with chronic hepatitis B with the current available treatments. AIM:To review the stud...

journal_title：Alimentary pharmacology & therapeutics

authors： Leemans WF,Ter Borg MJ,de Man RA

更新日期：2007-12-01 00:00:00

abstract：:Functional dyspepsia is highly variable in its clinical presentation and multifactorial in its underlying causes. Since many of the symptoms included in the definition of dyspepsia are intuitively suggestive of different pathogenic mechanisms, it has been proposed that patients with functional dyspepsia be divided int...

journal_title：Alimentary pharmacology & therapeutics

authors： Stanghellini V

更新日期：2001-02-01 00:00:00

abstract：:Gastric acid suppression is the most effective medical therapy to control acidic gastro-oesophageal reflux: individuals in whom therapy fails usually have inadequate acid suppression. Twenty-four-hour intragastric pH-metry measures the percentage of time that gastric pH is above 4 or 3, the critical thresholds for tis...

journal_title：Alimentary pharmacology & therapeutics

authors： Hatlebakk JG

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Acute gastrointestinal symptoms affect 90% of patients during pelvic radiotherapy. Elemental diet is protective in animal models. A nonrandomized study suggested benefit from a partial elemental diet. A pilot study suggested that radiotherapy patients only tolerate oral elemental diet comprising one-third of...

journal_title：Alimentary pharmacology & therapeutics

authors： McGough C,Wedlake L,Baldwin C,Hackett C,Norman AR,Blake P,Harrington K,Tait D,Khoo V,Frost G,Andreyev HJ

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The presenting symptoms of coeliac disease are often subtle and the diagnosis is frequently delayed or overlooked. Therefore, especially elderly patients may be denied the benefits conferred by gluten free diet which can be dramatically life-changing. AIM:To review the occurrence, clinical features, diagnos...

journal_title：Alimentary pharmacology & therapeutics

authors： Collin P,Vilppula A,Luostarinen L,Holmes GKT,Kaukinen K

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM:To examine retrospectively the effect of azathioprine (AZA) and mercaptopurine...

journal_title：Alimentary pharmacology & therapeutics

authors： Münch A,Fernandez-Banares F,Munck LK

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Distal ulcerative colitis may prove to be resistant to steroids and aminosalicylates, but total colectomy is more difficult to justify than in severe extensive colitis. Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease. AIM:To dete...

journal_title：Alimentary pharmacology & therapeutics

authors： Falasco G,Zinicola R,Forbes A

更新日期：2002-02-01 00:00:00

abstract：:Bismuth preparations are commonly used to treat a variety of gastrointestinal disorders, including peptic ulcers and dyspepsia. The safety profile of currently approved bismuth preparations, such as tripotassium dicitrato bismuthate (De-Nol), bismuth subsalicylate (Pepto-Bismol) and ranitidine bismuth citrate (Pylorid...

journal_title：Alimentary pharmacology & therapeutics

authors： Tillman LA,Drake FM,Dixon JS,Wood JR

更新日期：1996-08-01 00:00:00

abstract：:Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twe...

journal_title：Alimentary pharmacology & therapeutics

authors： Prewett EJ,Luk YW,Fraser AG,Lam WM,Pounder RE

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Surgical resection of Crohn's disease is followed by early recurrence in a high percentage of patients. Mesalazine has been shown to be effective in the prevention of post-operative recurrence, but some 50% of patients under treatment recur at 3 years of follow-up. AIM:To establish whether the mucosal conce...

journal_title：Alimentary pharmacology & therapeutics

authors： Frieri G,Pimpo MT,Andreoli A,Annese V,Comberlato M,Corrao G,Palumbo G,Sturniolo GC,Tonelli F,Caprilli R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Validated non-invasive measures of fatty liver are needed that can be applied across populations and over time. A fatty liver index (FLI) including body mass index, waist circumference, triglycerides and gamma glutamyltransferase (GGT) activity was developed in an Italian municipality, but has not been valid...

journal_title：Alimentary pharmacology & therapeutics

authors： Ruhl CE,Everhart JE

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:CagA protein is encoded by the cagA gene, which is part of the cag pathogenicity island (PAI) in Helicobacter pylori. Insertion sequence (IS) elements are a diverse set of specialized DNA segments that can move to new sites in bacterial genomes. AIM:To determine the role of cagPAI and IS605 in the developme...

journal_title：Alimentary pharmacology & therapeutics

authors： Deguchi R,Igarashi M,Watanabe K,Takagi A

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:The therapeutic effect of enteral nutrition in Crohn's disease (CD) and the epidemiological associations between diet and inflammatory bowel disease (IBD) implicate diet in IBD causation. There is little evidence, however, to support specific dietary changes and patients often receive contradictory advice. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Richman E,Rhodes JM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Guaiac-based faecal occult blood tests (g-FOBTs) are most commonly used in colorectal cancer (CRC) screening programmes. Faecal immunochemical tests (FITs) are thought to be superior. AIM:To compare performance of a g-FOBT and a quantitative FIT for detection of CRCs and advanced adenomas in a colonoscopy-c...

journal_title：Alimentary pharmacology & therapeutics

authors： Oort FA,Terhaar Sive Droste JS,Van Der Hulst RW,Van Heukelem HA,Loffeld RJ,Wesdorp IC,Van Wanrooij RL,De Baaij L,Mutsaers ER,van der Reijt S,Coupe VM,Berkhof J,Bouman AA,Meijer GA,Mulder CJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo-terminal ileum. AIM:To identify predictors of early post-operative endoscopic recurrence. METHODS:From September 2010 to September 2017, the REMIND group conducted a prospective n...

journal_title：Alimentary pharmacology & therapeutics

authors： Auzolle C,Nancey S,Tran-Minh ML,Buisson A,Pariente B,Stefanescu C,Fumery M,Marteau P,Treton X,Hammoudi N,REMIND Study Group Investigators.,Jouven X,Seksik P,Allez M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:In developed countries, hepatitis E is a porcine zoonosis caused by hepatitis E virus (HEV) genotype 3. In developing countries, hepatitis E is mainly caused by genotype 1, and causes increased mortality in patients with pre-existing chronic liver disease (CLD). AIM:To determine the role of HEV in patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： Blasco-Perrin H,Madden RG,Stanley A,Crossan C,Hunter JG,Vine L,Lane K,Devooght-Johnson N,Mclaughlin C,Petrik J,Stableforth B,Hussaini H,Phillips M,Mansuy JM,Forrest E,Izopet J,Blatchford O,Scobie L,Peron JM,Dalton H

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Attachment of Giardia lamblia trophozoites to enterocytes is essential for colonization of the small intestine and is considered a prerequisite for Giardia-induced enterocyte damage. Inhibition of attachment may therefore have therapeutic potential. METHODS:Enterocyte-like differentiated Caco-2 cells were u...

journal_title：Alimentary pharmacology & therapeutics

authors： Katelaris PH,Naeem A,Farthing MJ

更新日期：1994-04-01 00:00:00

abstract：:We compared the effects of fasting and feeding on the antisecretory actions of ranitidine in 19 patients whose duodenal ulcers remained unhealed or relapsed despite treatment with the drug. Nine of the patients received, and continued with, 150 mg ranitidine b.d. and 10 took 300 mg ranitidine b.d. In all patients, gas...

journal_title：Alimentary pharmacology & therapeutics

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies. AIM:To systematically evaluate whether adding probiotics to anti-H. pylori regimens could improve eradication rates and reduce side effects during anti-H. pylori treatment. METHODS:Eligib...

journal_title：Alimentary pharmacology & therapeutics

authors： Tong JL,Ran ZH,Shen J,Zhang CX,Xiao SD

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Oesophagitis is usually a chronic condition. Healing with omeprazole is often followed by early relapse. Combination treatment and subsequent maintenance treatment with the prokinetic cisapride may be of benefit in relapse prevention. METHODS:Patients with endoscopically proven oesophagitis, grade I (n = 12...

journal_title：Alimentary pharmacology & therapeutics

authors： Kimmig JM

更新日期：1995-06-01 00:00:00

abstract：:The bioavailability of three pure 5-aminosalicylic (5-ASA) preparations (Asacol, Claversal, and Pentasa) was studied in 8 ileostomy patients and 12 normal subjects after 6 days of treatment with 2000 mg 5-ASA. The local bioavailability, reflected by the 5-ASA concentration was thereby measured at two clinically releva...

journal_title：Alimentary pharmacology & therapeutics

authors： Christensen LA,Fallingborg J,Abildgaard K,Jacobsen BA,Sanchez G,Hansen SH,Bondesen S,Hvidberg EF,Rasmussen SN

更新日期：1990-10-01 00:00:00

abstract：AIM:To develop general rules on how to pursue a therapeutic goal of interventional endoscopy without getting lost in abundant details. METHODS:The influences of various medical interventions on the survival of a patient with gastrointestinal haemorrhage are modelled by an influence diagram. Survival is the focal point...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A,Gavin MW

更新日期：2002-05-01 00:00:00

abstract：:Physicians occasionally embark on a work-up that, after a lengthy path, leads them to a clinical situation similar to that from which they started their original pursuit. This article aims to describe the characteristics of circular medical management and means for its avoidance. The underlying medical problem often p...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Pancreatic enzyme replacement therapy (PERT) is necessary to prevent severe maldigestion and unwanted weight loss associated with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP) or pancreatic surgery (PS). AIM:To assess the long-term safety and efficacy of pancrelipase (pancreatin) ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gubergrits N,Malecka-Panas E,Lehman GA,Vasileva G,Shen Y,Sander-Struckmeier S,Caras S,Whitcomb DC

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Gastroprotective strategies are recommended for nonsteroidal anti-inflammatory drug (NSAID) users at risk of upper gastrointestinal (UGI) complications. AIM:To compare the use of gastroprotective strategies in NSAID users in three countries, and the subsequent impact of rofecoxib withdrawal. METHODS:We con...

journal_title：Alimentary pharmacology & therapeutics

authors： Valkhoff VE,van Soest EM,Masclee GM,de Bie S,Mazzaglia G,Molokhia M,Kuipers EJ,Sturkenboom MC

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Adverse events leading to discontinuation or dose reduction of thiopurine therapy occur in 9-28% of patients with inflammatory bowel disease. AIMS:To evaluate the influence of thiopurine methyltransferase status and thiopurine metabolites in a large patient population for the risk of developing adverse even...

journal_title：Alimentary pharmacology & therapeutics

authors： Hindorf U,Lindqvist M,Hildebrand H,Fagerberg U,Almer S

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Re-bleeding of Helicobacter pylori-associated peptic ulcer disease is reduced by H. pylori eradication. AIM:To validate a non-invasive test, the Premium Platinum HpSA stool test, in patients with upper gastrointestinal bleeding. METHODS:Stool samples of consecutive patients with relevant bleeding from gast...

journal_title：Alimentary pharmacology & therapeutics

authors： Peitz U,Leodolter A,Kahl S,Agha-Amiri K,Wex T,Wolle K,Günther T,Steinbrink B,Malfertheiner P

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Gastro-oesophageal reflux disease (GERD) is one of the commonest diseases of Western populations, affecting 20 to 30% of adults. GERD is multifaceted and the classical oesophageal symptoms such as heartburn and regurgitation often overlap with atypical symptoms that impact upon the respiratory system and air...

journal_title：Alimentary pharmacology & therapeutics

authors： Pearson JP,Parikh S,Orlando RC,Johnston N,Allen J,Tinling SP,Johnston N,Belafsky P,Arevalo LF,Sharma N,Castell DO,Fox M,Harding SM,Morice AH,Watson MG,Shields MD,Bateman N,McCallion WA,van Wijk MP,Wenzl TG,Karkos

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Therapeutic options for achalasia include pharmacological therapy, surgical myotomy, pneumatic dilatation and intrasphincteric botulinum toxin injection. AIM:To compare botulinum toxin injection with pneumatic dilatation in a randomized trial. PATIENTS/METHODS:Forty adults with newly diagnosed achalasia we...

journal_title：Alimentary pharmacology & therapeutics

authors： Mikaeli J,Fazel A,Montazeri G,Yaghoobi M,Malekzadeh R

更新日期：2001-09-01 00:00:00