Prersonal view: going around in circles -- circuitous medical management plans.

abstract：BACKGROUND:Proton pump inhibitors including omeprazole and lansoprazole inhibit gastric acid secretion by selectively and non-competitively inactivating the H+, K+ ATPase molecules of the parietal cell, but possibly only those that are actively secreting acid. This might imply that stimulation of acid secretion by a me...

journal_title：Alimentary pharmacology & therapeutics

authors： Hatlebakk JG,Katz PO,Camacho-Lobato L,Castell DO

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Several studies have explored the effect of non-alcoholic fatty liver disease (NAFLD) on bone mineral density (BMD) and risk of osteoporotic fractures in adults. However, the extent to which NAFLD adversely affects bone health remains uncertain. AIM:To provide a quantitative estimation of the magnitude of t...

journal_title：Alimentary pharmacology & therapeutics

authors： Mantovani A,Dauriz M,Gatti D,Viapiana O,Zoppini G,Lippi G,Byrne CD,Bonnet F,Bonora E,Targher G

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The presence of antibodies towards infliximab (ATI) is associated with lower infliximab (IFX) trough concentrations and loss of response. IFX treatment intensification is effective for restoring response in most, but not all patients with Crohn's disease (CD). AIM:To compare outcome, pharmacokinetics and im...

journal_title：Alimentary pharmacology & therapeutics

authors： Dreesen E,Van Stappen T,Ballet V,Peeters M,Compernolle G,Tops S,Van Steen K,Van Assche G,Ferrante M,Vermeire S,Gils A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:No definitive method for quantitative evaluation of hepatic function has as yet been established. AIM:To investigate whether the (13)C-phenylalanine breath test would be useful for the evaluation of hepatic function in patients with liver cirrhosis and acute hepatitis. METHODS:L-[1-(13)C]-phenylalanine was...

journal_title：Alimentary pharmacology & therapeutics

authors： Koeda N,Iwai M,Kato A,Suzuki K

更新日期：2005-04-01 00:00:00

abstract：:Gastro-oesophageal reflux disease is a motor disorder principally caused by defective function of the lower oesophageal sphincter. Proton pump inhibitor (PPI) drugs alleviate symptoms, heal oesophagitis and improve quality of life but do not address the underlying motor disorder, and prolonged treatment is often neede...

journal_title：Alimentary pharmacology & therapeutics

authors： Palmer K

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Refractory sprue with malabsorption carries a risk of lymphoma. AIM:To examine whether a good clinical but poor histological response during a strict gluten-free diet predicts a poor outcome. METHODS:The study involved all coeliac patients who showed no histological recovery within 2 years on a strict glut...

journal_title：Alimentary pharmacology & therapeutics

authors： Kaukinen K,Peräaho M,Lindfors K,Partanen J,Woolley N,Pikkarainen P,Karvonen AL,Laasanen T,Sievänen H,Mäki M,Collin P

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5-hydroxytryptamine receptors on dermal sensory nerve-endings plays a role in the perception of pruritus. The 5-hydroxytryptamine(3) receptor antagonist, ondansetron, has been used in the tr...

journal_title：Alimentary pharmacology & therapeutics

authors： O'Donohue JW,Pereira SP,Ashdown AC,Haigh CG,Wilkinson JR,Williams R

更新日期：2005-04-15 00:00:00

abstract：BACKGROUND:Transjugular intrahepatic portosystemic stent-shunts (TIPSS) are becoming widely used in the management of oesophageal variceal haemorrhage (OVH). Their place in the treatment of gastric variceal haemorrhage (GVH), a condition with a traditionally poor prognosis, remains unclear. The aims of our study were t...

journal_title：Alimentary pharmacology & therapeutics

authors： Stanley AJ,Jalan R,Ireland HM,Redhead DN,Bouchier IA,Hayes PC

更新日期：1997-02-01 00:00:00

abstract：:At present, the concept of visceral hypersensitivity provides the leading hypothesis regarding the generation of symptoms in functional gastrointestinal disorders. This paper discusses the current clinical evidence for drugs that have been proposed to interfere with visceral sensitivity in functional gastrointestinal ...

journal_title：Alimentary pharmacology & therapeutics

authors： Kuiken SD,Tytgat GN,Boeckxstaens GE

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function. AIM:To examine mast cell, eosinophil and intraepithelial lymphocyte populatio...

journal_title：Alimentary pharmacology & therapeutics

authors： Walker MM,Talley NJ,Prabhakar M,Pennaneac'h CJ,Aro P,Ronkainen J,Storskrubb T,Harmsen WS,Zinsmeister AR,Agreus L

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and are associated with poor outcomes. AIM:To provide an overview of data on the importance, assessment and management of malnutrition/sarcopenia and frailty in cirrhosis. METHODS:A literature search was conducted in PubMed and other...

journal_title：Alimentary pharmacology & therapeutics

authors： Bunchorntavakul C,Reddy KR

更新日期：2020-01-01 00:00:00

abstract：:Epidemiological, experimental, and clinical studies have demonstrated that colon carcinogenesis may be prevented by nonsteroidal anti-inflammatory drugs (NSAIDs). Although controversy remains, recent studies, including ours, have revealed that NSAIDs suppress colon carcinogenesis at the adenoma stage where cyclooxygen...

journal_title：Alimentary pharmacology & therapeutics

authors： Ota S,Bamba H,Kato A,Kawamoto C,Yoshida Y,Fujiwara K

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:HS-10234 is a novel prodrug of tenofovir developed to increase anti-viral potency and to reduce systemic toxicities. AIMS:To evaluate the tolerability, pharmacokinetics and anti-viral efficacy of HS-10234 in patients with chronic hepatitis B (CHB) infection METHODS: Treatment-naïve subjects with non-cirrhot...

journal_title：Alimentary pharmacology & therapeutics

authors： Zhang H,Hu Y,Wu M,Liu J,Zhu X,Li X,Chen H,Li C,Liu C,Niu J,Ding Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:There are patients with chronic hepatitis C who are not eligible for the current interferon-based therapies or refuse to be treated due to secondary effects. AIM:To provide information on alternative treatments for the management of these patients. METHODS:A PubMed search was performed to identify relevant...

journal_title：Alimentary pharmacology & therapeutics

authors： Carreño V

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The prevalence of coeliac disease (CD) may be increased in individuals with dyspepsia, but evidence is conflicting. AIMS:To conduct a systematic review and meta-analysis of studies reporting prevalence of CD in dyspepsia. METHODS:MEDLINE, EMBASE, and CINAHL were searched up to February 2009. Case series an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ford AC,Ching E,Moayyedi P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. AIM:To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantag...

journal_title：Alimentary pharmacology & therapeutics

authors： Caprilli R,Cottone M,Tonelli F,Sturniolo G,Castiglione F,Annese V,Papi C,Viscido A,Cammà C,Corrao G,Latella G

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan. AIM:To estimate the preventive effect by normal dose, not high-dose histamine-H2 receptor antagonists (H2RA) for NSAID-induced ulce...

journal_title：Alimentary pharmacology & therapeutics

authors： Miyake K,Ueki N,Suzuki K,Shinji Y,Kusunoki M,Hiratsuka T,Nishigaki H,Tatsuguchi A,Futagami S,Wada K,Tsukui T,Nakajima A,Yoshino S,Sakamoto C

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Distal ulcerative colitis may prove to be resistant to steroids and aminosalicylates, but total colectomy is more difficult to justify than in severe extensive colitis. Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease. AIM:To dete...

journal_title：Alimentary pharmacology & therapeutics

authors： Falasco G,Zinicola R,Forbes A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Two studies were carried out in order to investigate the issue of meal-provoked nocturnal gastrooesophageal reflux. METHODS:In Experiment 1, 20 symptomatic reflux patients underwent both pH and polysomnographic monitoring on two nights. On one night, patients ate a non-provocative meal prior to 19.00 hours,...

journal_title：Alimentary pharmacology & therapeutics

authors： Orr WC,Harnish MJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Comparative long-term efficacy of entecavir (ETV) and tenofovir disoproxil fumarate (TDF) for prevention of disease progression to hepatocellular carcinoma (HCC) among high-risk patients with chronic hepatitis B (CHB)-related compensated cirrhosis is controversial. AIMS:To compare the long-term efficacy of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu TH,Yueh-Hsia Chiu S,Tseng PL,Chen CH,Lu SN,Wang JH,Hung CH,Kee KM,Lin MT,Chang KC,Lin MC,Chien RN

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Controversy exists on how to measure patient-reported outcomes in irritable bowel syndrome (IBS) clinical trials effectively. Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS. AIM:To test the psychometrics of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spiegel B,Bolus R,Harris LA,Lucak S,Naliboff B,Esrailian E,Chey WD,Lembo A,Karsan H,Tillisch K,Talley J,Mayer E,Chang L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

更新日期：2007-05-01 00:00:00

abstract：:The effect of ephedrine, a non-selective adrenoreceptor agonist, and yohimbine, a selective alpha 2-adrenolytic drug, on gastric emptying of a radiolabelled solid meal was examined in groups of 8 (all women) and 15 (4 men and 11 women) obese patients, respectively. Patients were given orally, double-blind in random or...

journal_title：Alimentary pharmacology & therapeutics

authors： Jonderko K,Kucio C

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. AIM:To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy...

journal_title：Alimentary pharmacology & therapeutics

authors： Katzka DA,Castell DO

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Mycophenolate mofetil has been claimed to be effective and well tolerated in refractory inflammatory bowel disease although there is little information regarding its use in clinical practice. AIM:To review our experience in achieving and maintaining remission in refractory inflammatory bowel disease and to ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ford AC,Towler RJ,Moayyedi P,Chalmers DM,Axon AT

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The effect of anti-viral treatment on downstream costs for hepatitis C virus (HCV)-infected patients is unknown. AIM:To evaluate follow-up costs in patients with chronic HCV, stratified by liver disease severity. METHODS:Using a US private insurance database, mean all-cause per-patient-per-month (PPPM) US ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gordon SC,Hamzeh FM,Pockros PJ,Hoop RS,Buikema AR,Korner EJ,Terrault NA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Little is known about the distinctive characteristics of subjects with frequent (at least weekly) and occasional gastro-oesophageal reflux symptoms. AIM:To compare the characteristics and disease management of subjects complaining of at least weekly and less frequent gastro-oesophageal reflux symptoms. MET...

journal_title：Alimentary pharmacology & therapeutics

authors： Bretagne JF,Honnorat C,Richard-Molard B,Caekaert A,Barthélemy P

更新日期：2006-03-01 00:00:00

abstract：AIM:To compare the efficacy of ranitidine bismuth citrate plus clarithromycin (RBC-C) vs. omeprazole plus amoxycillin (OME-AMO) in the cure of Helicobacter pylori infection. METHODS:In this double-blind, multicentre, parallel-group study 122 H. pylori-positive patients with active duodenal ulcer or gastritis, with con...

journal_title：Alimentary pharmacology & therapeutics

authors： Kolkman JJ,Tan TG,Oudkerk Pool M,Van Kleef WA,Geraedts AA,Timmerman RJ,Crobach LF,Nicolai JJ,Wolff AA,Van Der Laan J

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:In 1997-1998, 6127 asymptomatic children aged 2-4 years were screened for coeliac disease (CD) by anti-endomysium (EmA) testing in the Netherlands. After 6 (+/-2) months, biopsies were performed in 57 seropositive children; 31(54%) had villous atrophy, but 26 (46%), all HLA-DQ2/DQ8 positive, had normal histo...

journal_title：Alimentary pharmacology & therapeutics

authors： Hogen Esch CE,Csizmadia GD,van Hoogstraten IM,Schreurs MW,Mearin ML,von Blomberg BM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:For patients with UC, flexible maintenance dosing therapy may confer advantages for safety, efficacy, costs and patient preference. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of UC. AIM:To assess the efficacy and safety of tofacitinib dose de-escalation and escalation in patients...

journal_title：Alimentary pharmacology & therapeutics

authors： Sands BE,Armuzzi A,Marshall JK,Lindsay JO,Sandborn WJ,Danese S,Panés J,Bressler B,Colombel JF,Lawendy N,Maller E,Zhang H,Chan G,Salese L,Tsilkos K,Marren A,Su C

更新日期：2020-01-01 00:00:00