A controlled trial of ondansetron in the pruritus of cholestasis.

abstract：BACKGROUND:There is expanding interest in the role that diet plays in ileoanal pouch function and in the pathogenesis of pouchitis. AIMS:To present a narrative review of published literature regarding the relationship of diet with pouch function and the pathogenesis of pouchitis, and to provide potentially beneficial ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ardalan ZS,Yao CK,Sparrow MP,Gibson PR

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Efficacy and safety of antiviral combination therapy in patients with Crohn's disease (CD) and chronic hepatitis C (CHC) is presently not established and consequently CHC is rarely treated in CD patients. AIM:To analyse the efficacy and tolerability of antiviral interferon/ribavirin therapy in patients with...

journal_title：Alimentary pharmacology & therapeutics

authors： Scherzer TM,Staufer K,Novacek G,Steindl-Munda P,Schumacher S,Hofer H,Ferenci P,Vogelsang H

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. AIM:To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantag...

journal_title：Alimentary pharmacology & therapeutics

authors： Caprilli R,Cottone M,Tonelli F,Sturniolo G,Castiglione F,Annese V,Papi C,Viscido A,Cammà C,Corrao G,Latella G

更新日期：2003-02-15 00:00:00

abstract：:Candidiasis of the oropharynx and oesophagus is one of the most common problems encountered in patients with HIV disease. Fluconazole is a bis-triazole antifungal agent with a long serum half-life. Sixteen anti-HIV positive patients (15 haemophiliacs and one blood transfusion recipient) with a clinical diagnosis of or...

journal_title：Alimentary pharmacology & therapeutics

authors： Lim SG,Lee CA,Hales M,O'Doherty M,Winter M,Kernoff PB

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

journal_title：Alimentary pharmacology & therapeutics

authors： Mönkemüller KE,Hirschowitz BI

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The mucosa-associated microbiota appears to be highly relevant to host-microbe interactions in the gastrointestinal (GI) tract. Thus, precise characterisation of the mucosa-associated microbiota may provide important insights for diagnostic and therapeutic development. However, for technical reasons, mucosal...

journal_title：Alimentary pharmacology & therapeutics

authors： Shanahan ER,Zhong L,Talley NJ,Morrison M,Holtmann G

更新日期：2016-06-01 00:00:00

abstract：:The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease is prevalent in affluent countries and is strongly associated with metabolic syndrome. AIM:To study the prevalence of undiagnosed diabetes and postchallenge hyperglycaemia in Chinese patients with non-alcoholic fatty liver disease. METHODS:73 consecutive patients with biop...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong VW,Hui AY,Tsang SW,Chan JL,Wong GL,Chan AW,So WY,Cheng AY,Tong PC,Chan FK,Sung JJ,Chan HL

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:The widespread use of eradication therapy for Helicobacter pylori in Japan has led to an increase in antibiotic-resistant strains and the problem of re-treatment in cases of eradication failure. AIM:To perform drug sensitivity testing for metronidazole in 92 H. pylori-positive patients who had failed eradic...

journal_title：Alimentary pharmacology & therapeutics

authors： Murakami K,Sato R,Okimoto T,Nasu M,Fujioka T,Kodama M,Kagawa J

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Population-based data on gastro-oesophageal reflux in Latin America are lacking. AIM:To assess gastro-oesophageal reflux symptom prevalence, clinical spectrum and association with the atypical symptoms in our country. METHODS:Gastro-oesophageal reflux self-report questionnaires validated at Mayo Clinic, US...

journal_title：Alimentary pharmacology & therapeutics

authors： Chiocca JC,Olmos JA,Salis GB,Soifer LO,Higa R,Marcolongo M,ARGENTINEAN GASTRO-OESOPHAGEAL REFLUX STUDY GROUP.

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:The association between myocardial infarction (MI) and co-administration of proton pump inhibitors (PPIs) and clopidogrel remains controversial. AIM:To quantify the association between concomitant use of PPIs and clopidogrel and occurrence of recurrent MI. METHODS:We conducted a case-control study within a...

journal_title：Alimentary pharmacology & therapeutics

authors： Valkhoff VE,'t Jong GW,Van Soest EM,Kuipers EJ,Sturkenboom MC

更新日期：2011-01-01 00:00:00

abstract：:Suppositories containing 300 mg 5-aminosalicylic acid (1.96 mmol) or 425 mg acetyl-5-aminosalicylic acid (1.96 mmol) were used in 40 patients with idiopathic proctitis to determine the efficacy of acetyl-5-aminosalicylic acid in treating this bowel inflammation. Each patient was treated with 5-aminosalicylic acid or a...

journal_title：Alimentary pharmacology & therapeutics

authors： van Hogezand RA,van Hees PA,van Gorp JP,van Lier HJ,Bakker JH,Wesseling P,van Haelst UJ,van Tongeren JH

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Guidelines recommend withholding sofosbuvir (SOF) in patients with an estimated glomerular filtration rate (eGFR) of less than 30 mL/min. AIM:To assess the risk of acute kidney injury (AKI) in patients with no renal contraindications for SOF-based treatment. METHODS:This multicenter retrospective observati...

journal_title：Alimentary pharmacology & therapeutics

authors： Maan R,Al Marzooqi SH,Klair JS,Karkada J,Cerocchi O,Kowgier M,Harrell SM,Rhodes KD,Janssen HLA,Feld JJ,Duarte-Rojo A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism (VTE). AIM:To provide a quantitative assessment of the association of IBD with venous thromboembo...

journal_title：Alimentary pharmacology & therapeutics

authors： Yuhara H,Steinmaus C,Corley D,Koike J,Igarashi M,Suzuki T,Mine T

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel diseases (IBD) have an increased risk of clostridium difficile infection (CDI). Cathelicidins are anti-microbial peptides that attenuate colitis and inhibit the effect of clostridial toxins. Plasma calcifediol [25(OH)D] stimulates production of cathelicidins. AIM:To examine ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Cagan A,Gainer VS,Cheng SC,Cai T,Szolovits P,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma is the leading cause of death in cirrhosis. A majority of patients present at an advanced stage with poor prognosis. AIM:To review the current screening, diagnosis and management strategies involved in hepatocellular carcinoma. METHODS:A literature search was performed using PubMed...

journal_title：Alimentary pharmacology & therapeutics

authors： Cabrera R,Nelson DR

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:A variety of tests have been proposed for colorectal cancer (CRC), giving rise to uncertainty regarding the optimal approach. The efficacy and effectiveness of different tests are related to both screened participation and the detection rate. AIM:To perform a meta-analysis on adherence and detection rates o...

journal_title：Alimentary pharmacology & therapeutics

authors： Hassan C,Giorgi Rossi P,Camilloni L,Rex DK,Jimenez-Cendales B,Ferroni E,Borgia P,Zullo A,Guasticchi G,HTA Group.

更新日期：2012-11-01 00:00:00

abstract：:The treatment of severe and active Crohn's disease is currently based on immunosuppression, but also involves the management of nutrition, appropriate selection of patients for surgery, and maintenance of remission in the long term. Corticosteroids remain the drug of the first choice, particularly in the acute setting...

journal_title：Alimentary pharmacology & therapeutics

authors： Parkes M,Jewell DP

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Direct-acting antiviral (DAA) regimens have shown high efficacy and tolerability for patients with HCV genotype 1/1b (GT1/1b) in clinical trials. However, robust real-world evidence of interferon (IFN)-free DAA treatment for HCV GT1-infected patients in Asia is still lacking. AIM:To systematically review an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ji F,Wei B,Yeo YH,Ogawa E,Zou B,Stave CD,Li Z,Dang S,Furusyo N,Cheung RC,Nguyen MH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor α (anti-TNF) agents have been implicated in drug-induced liver injury. There is minimal data on this occurrence in inflammatory bowel disease (IBD) patients. AIM:To identify the characteristics of liver enzyme elevations following anti-TNF therapy initiation in IBD. METHODS:A re...

journal_title：Alimentary pharmacology & therapeutics

authors： Shelton E,Chaudrey K,Sauk J,Khalili H,Masia R,Nguyen DD,Yajnik V,Ananthakrishnan AN

更新日期：2015-05-01 00:00:00

abstract：:The risk of colorectal cancer for any patient with ulcerative colitis is estimated to be 2% after 10 years, 8% after 20 years and 18% after 30 years of disease. The relative risk of colorectal cancer in Crohn's colitis is approximately 5.6 and should raise the same concerns as in ulcerative colitis. Risk factors for c...

journal_title：Alimentary pharmacology & therapeutics

authors： Eaden J

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Data on whether long-acting somatostatin analogue octreotide causes or prevents pancreatic injury following endoscopic retrograde cholangiopancreatography (ERCP) are controversial. AIM:This multicentre, prospective trial studied the effect of octreotide on pancreatic injury in a large unselected group of pa...

journal_title：Alimentary pharmacology & therapeutics

authors： Tulassay Z,Döbrönte Z,Prónai L,Zágoni T,Juhász L

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:In the absence of prior gastrointestinal infection, the risk factors for irritable bowel syndrome (IBS) are not well established. AIM:To identify the incidence and risk factors for IBS in general population samples METHODS: Narrative review of population-based studies. Electronic databases were searched usi...

journal_title：Alimentary pharmacology & therapeutics

authors： Creed F

更新日期：2019-09-01 00:00:00

abstract：:The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than...

journal_title：Alimentary pharmacology & therapeutics

authors： McLauchlan G,Crean GP,McColl KE

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) risk after resolving chronic hepatitis B virus (HBV) infection is unclear. AIM:To compare HCC risk between Alaska Native (AN) patients with and without hepatitis B surface antigen (HBsAg) seroclearance. METHODS:We selected persons with (case-patients) and without (control-pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Gounder PP,Bulkow LR,Snowball M,Negus S,Spradling PR,Simons BC,McMahon BJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel diseases (IBD) commonly affect young patients in the reproductive phase of their lives. The chronic and relapsing nature of IBD and the potential need for medical or surgical interventions raise concerns about family planning issues. AIM:To review the current knowledge on IBD management i...

journal_title：Alimentary pharmacology & therapeutics

authors： Schulze H,Esters P,Dignass A

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. AIM:To determine the use of proton pump inhibitors and H2 -re...

journal_title：Alimentary pharmacology & therapeutics

authors： Lødrup A,Pottegård A,Hallas J,Bytzer P

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Hispanic-Americans are a rapidly growing population in the United States, yet gastro-oesophageal reflux disease (GERD) is not well studied in this population. AIM:To compare the efficacy of esomeprazole, lansoprazole and pantoprazole in suppressing gastric acid, including the area of the 'acid pocket,' in H...

journal_title：Alimentary pharmacology & therapeutics

authors： Morgan D,Pandolfino J,Katz PO,Goldstein JL,Barker PN,Illueca M

更新日期：2010-07-01 00:00:00

abstract：:The knowledge of the natural history of patients with hepatocellular carcinoma is important to estimate the prognosis at diagnosis and indicate the best therapy. Prognosis is related to tumour stage at diagnosis, degree of liver function impairment induced either by the tumour itself or by the underlying cirrhosis, ge...

journal_title：Alimentary pharmacology & therapeutics

authors： Varela M,Sala M,Llovet JM,Bruix J

更新日期：2003-06-01 00:00:00