Meta-analysis: adherence to colorectal cancer screening and the detection rate for advanced neoplasia, according to the type of screening test.

abstract：BACKGROUND:Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. AIM:To determine the use of proton pump inhibitors and H2 -re...

journal_title：Alimentary pharmacology & therapeutics

authors： Lødrup A,Pottegård A,Hallas J,Bytzer P

更新日期：2015-07-01 00:00:00

abstract：:Erythromycin is a prokinetic agent for the lower oesophageal sphincter, the stomach, the gallbladder and the small bowel, acting directly on motilin receptors. Its effect on pressure activity of the human colon has not been investigated. Eight healthy volunteers were studied on 2 occasions and given intravenous or ora...

journal_title：Alimentary pharmacology & therapeutics

authors： Jameson JS,Rogers J,Misiewicz JJ,Raimundo AH,Henry MM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Data on tenofovir alafenamide fumarate (TAF) for preventing mother-to-child transmission of hepatitis B virus (HBV) are lacking. AIMS:To investigate the efficacy and safety of TAF therapy for preventing hepatitis B mother-to-child transmission. METHODS:Mothers with chronic HBV infection, positive for hepat...

journal_title：Alimentary pharmacology & therapeutics

authors： Ding Y,Cao L,Zhu L,Huang Y,Lin C,Wang Y,Liu Y,Sheng Q,Wang S,Fan J,Chen R,Gan W,Chen B,Pan CQ

更新日期：2020-10-01 00:00:00

abstract：AIM:To define the characteristics of patients consulting with active dyspeptic symptoms in urban general practice, and to consider the implications of applying the British Society of Gastroenterology Dyspepsia management guidelines. DESIGN:Prospective observational study over a period of 12 months. SETTING:Two multip...

journal_title：Alimentary pharmacology & therapeutics

authors： Bodger K,Eastwood PG,Manning SI,Daly MJ,Heatley RV

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Epidemiological studies of microscopic colitis have shown varying but increasing incidence rates. AIM:To assess the incidence of microscopic colitis in Sweden. METHODS:Nationwide cohort study performed in 1995-2015 based on biopsy reports. Age-specific and age-standardised incidence rates were calculated. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Bergman D,Clements MS,Khalili H,Agréus L,Hultcrantz R,Ludvigsson JF

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Cyclo-oxygenase-2 expression has been reported to play an important role in the metaplasia-dysplasia-carcinoma sequence in Barrett's oesophagus. However, the existence of cyclo-oxygenase-2 expressing cells in Barrett's epithelium is still uncertain. AIM:To identify the cells that express cyclo-oxygenase-2 p...

journal_title：Alimentary pharmacology & therapeutics

authors： Amano Y,Ishihara S,Kushiyama Y,Yuki T,Takahashi Y,Chinuki D,Miyake T,Miyaoka Y,Rumi MA,Ishimura N,Adachi K,Kinoshita Y

更新日期：2004-10-01 00:00:00

abstract：:Bismuth preparations are commonly used to treat a variety of gastrointestinal disorders, including peptic ulcers and dyspepsia. The safety profile of currently approved bismuth preparations, such as tripotassium dicitrato bismuthate (De-Nol), bismuth subsalicylate (Pepto-Bismol) and ranitidine bismuth citrate (Pylorid...

journal_title：Alimentary pharmacology & therapeutics

authors： Tillman LA,Drake FM,Dixon JS,Wood JR

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond. AIMS:To determine whether in-vitro sensitivity to cyclosporin as measured ...

journal_title：Alimentary pharmacology & therapeutics

authors： McCormack G,O'Donoghue D,Baird A

更新日期：2001-05-01 00:00:00

abstract：:The knowledge of the natural history of patients with hepatocellular carcinoma is important to estimate the prognosis at diagnosis and indicate the best therapy. Prognosis is related to tumour stage at diagnosis, degree of liver function impairment induced either by the tumour itself or by the underlying cirrhosis, ge...

journal_title：Alimentary pharmacology & therapeutics

authors： Varela M,Sala M,Llovet JM,Bruix J

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Many patients are not symptom-free after eradication therapy for Helicobacter pylori and continue to use proton pump inhibitors or H2-receptor antagonists (H2-RAs). AIM:To ascertain whether a cohort of patients treated for H. pylori were still taking either proton pump inhibitors or H2-RAs more than 4 years...

journal_title：Alimentary pharmacology & therapeutics

authors： Tan AC,Hartog GD,Mulder CJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Common risk factors exist in colorectal neoplasia (cancer or adenoma) and coronary artery disease. AIM:To investigate in a retrospective study if there is coexistence of the two events in patients > OR =50 years. METHODS:Computer data on colonoscopies performed on symptomatic patients, the corresponding me...

journal_title：Alimentary pharmacology & therapeutics

authors： Chan AO,Lam KF,Tong T,Siu DC,Jim MH,Hui WM,Lai KC,Yuen MF,Lam SK,Wong BC

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

journal_title：Alimentary pharmacology & therapeutics

authors： Mönkemüller KE,Hirschowitz BI

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. AIMS:To determine whether circulating microRNAs are reliable biomarkers for IBD monitoring. METHODS:Serum levels of 17 candidate microRNAs were measured by quantitative real-t...

journal_title：Alimentary pharmacology & therapeutics

authors： Chen P,Li Y,Li L,Yu Q,Chao K,Zhou G,Qiu Y,Feng R,Huang S,He Y,Chen B,Chen M,Zeng Z,Zhang S

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is associated with metabolic manifestations including insulin resistance and diabetes through various mechanisms. Whether HCV infection is associated with an increased risk of post-transplant diabetes in liver transplant recipients is unclear. AIM:To assess the association of HCV inf...

journal_title：Alimentary pharmacology & therapeutics

authors： Younossi Z,Stepanova M,Saab S,Trimble G,Mishra A,Henry L

更新日期：2015-01-01 00:00:00

abstract：:Six asymptomatic, non-smoking men with endoscopically proven duodenal ulcer disease received single nocturnal doses of placebo, 40 mg famotidine and 300 mg ranitidine each for 1 week prior to serial measurement of pH, peptic activity and serum gastrin concentrations over 24 h and of acid output. The intragastric pH fl...

journal_title：Alimentary pharmacology & therapeutics

authors： Thomson AB,Pinchbeck BR,Kirdeikis J,Zuk L,Marriage B,Prat A

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:The association between ulcerative colitis and cytomegalovirus (CMV) has been recognised for over 50 years; and the role of CMV in ulcerative colitis in general, and steroid resistance in particular, remains a topic of ongoing controversy. The outcome for patients with CMV reactivation appears worse than tha...

journal_title：Alimentary pharmacology & therapeutics

authors： Sager K,Alam S,Bond A,Chinnappan L,Probert CS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:It is controversial whether chronic hepatitis B (CHB) patients have more non-liver comorbidities than non-CHB subjects. AIM:To characterise the demographics, comorbidity and health utilisation of CHB patients in South Korea and compare them to matched controls. METHODS:Using the Health Insurance Review & A...

journal_title：Alimentary pharmacology & therapeutics

authors： Oh H,Jun DW,Lee IH,Ahn HJ,Kim BO,Jung S,Nguyen MH

更新日期：2020-07-01 00:00:00

abstract：:The decision regarding prophylactic treatment after surgery in Crohn's disease (CD) requires a good estimation of the risk of recurrence. It is also important to consider the consequences of recurrence for the patient, and the risks and benefits of treatment, bearing in mind that it will be given over a long period. S...

journal_title：Alimentary pharmacology & therapeutics

authors： Lémann M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional disorders without defined pathology. Mast cells and eosinophils interact with T lymphocytes and may alter enteric nerve and smooth muscle function. AIM:To examine mast cell, eosinophil and intraepithelial lymphocyte populatio...

journal_title：Alimentary pharmacology & therapeutics

authors： Walker MM,Talley NJ,Prabhakar M,Pennaneac'h CJ,Aro P,Ronkainen J,Storskrubb T,Harmsen WS,Zinsmeister AR,Agreus L

更新日期：2009-04-01 00:00:00

abstract：AIM:To assess the efficacy of a prokinetic agent in the long-term treatment of chronic intestinal dysmotility and the influence of extrinsic denervation. METHODS:We assessed symptoms, compliance and untoward effects in an open, 1-year trial of cisapride, 20 mg t.d.s., in 37 patients with neuropathic forms of chronic i...

journal_title：Alimentary pharmacology & therapeutics

authors： Camilleri M,Balm RK,Zinsmeister AR

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:A direct role for neutrophils in the pathophysiology of indomethacin-induced gastric damage is controversial. Therefore, such damage was evaluated in hamsters. METHODS:Gastric antral damage was evaluated 4 h after the oro-gastric administration of indomethacin (30 mg/kg). Prior to indomethacin, hamsters wer...

journal_title：Alimentary pharmacology & therapeutics

authors： Fitzpatrick LR,Sakurai K,Le T

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel diseases (IBD) have an increased risk of clostridium difficile infection (CDI). Cathelicidins are anti-microbial peptides that attenuate colitis and inhibit the effect of clostridial toxins. Plasma calcifediol [25(OH)D] stimulates production of cathelicidins. AIM:To examine ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Cagan A,Gainer VS,Cheng SC,Cai T,Szolovits P,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Patients on maintenance dialysis typically show a suboptimal immune response to hepatitis B virus vaccine compared with the non-uraemic population. Some authors have claimed that dialysis mode has an impact on the immune response to hepatitis B virus vaccine but consistent information is lacking on this issu...

journal_title：Alimentary pharmacology & therapeutics

authors： Fabrizi F,Dixit V,Bunnapradist S,Martin P

更新日期：2006-04-15 00:00:00

abstract：BACKGROUND:Adalimumab is effective in inducing remission in patients with active Crohn's disease who had secondary failure to infliximab therapy. AIM:To evaluate the efficacy and safety of adalimumab maintenance therapy in Crohn's disease patients who previously responded to infliximab and then lost response or became...

journal_title：Alimentary pharmacology & therapeutics

authors： Peyrin-Biroulet L,Laclotte C,Bigard MA

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:Abnormal gall-bladder motility has been reported in diabetics. The objective was to evaluate the effect of chronic D2-dopamine receptor inhibition on gall-bladder emptying in diabetic patients. METHODS:Under double-blind placebo-controlled conditions and according to a crossover design, patients were random...

journal_title：Alimentary pharmacology & therapeutics

authors： Mansi C,Savarino V,Vigneri S,Sciabà L,Perilli D,Mele MR,Celle G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

journal_title：Alimentary pharmacology & therapeutics

authors： Houlihan DD,Holt A,Elliot C,Ferguson JW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although highly prevalent, little is known about the economic impact of functional dyspepsia (FD). AIMS:To quantify FD patients' health care utilisation patterns and to estimate direct and indirect costs of FD to patients. METHODS:ICD-9 codes identified adult patients with dyspepsia. A validated questionna...

journal_title：Alimentary pharmacology & therapeutics

authors： Lacy BE,Weiser KT,Kennedy AT,Crowell MD,Talley NJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Patient-reported outcome (PRO) measures historically used in inflammatory bowel disease have been considered inadequate to support future drug labelling claims by regulatory agencies. AIMS:To develop PRO tools for use in Crohn's disease (CD) and ulcerative colitis (UC) following guidance issued by the US FD...

journal_title：Alimentary pharmacology & therapeutics

authors： Dulai PS,Jairath V,Khanna R,Ma C,McCarrier KP,Martin ML,Parker CE,Morris J,Feagan BG,Sandborn WJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is the second commonest cause of cancer mortality. Some countries are implementing colorectal cancer screening to detect lesions at an early stage using non-invasive tools like the faecal immunochemical test. Despite affordability, this test shows a low sensitivity for precancerous lesions ...

journal_title：Alimentary pharmacology & therapeutics

authors： Malagón M,Ramió-Pujol S,Serrano M,Serra-Pagès M,Amoedo J,Oliver L,Bahí A,Mas-de-Xaxars T,Torrealba L,Gilabert P,Miquel-Cusachs JO,García-Nimo L,Saló J,Guardiola J,Piñol V,Cubiella J,Castells A,Aldeguer X,Garcia-Gil J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown that pH is an important determinant of mucus structure and function, but the relationship in vivo is unclear. Omeprazole increases intragastric pH and also allows bacterial overgrowth. In this study we have assessed the effect of omeprazole on gastric juice viscosity and examined ...

journal_title：Alimentary pharmacology & therapeutics

authors： Goddard AF,Spiller RC

更新日期：1996-02-01 00:00:00