Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?

Abstract:

BACKGROUND:A direct role for neutrophils in the pathophysiology of indomethacin-induced gastric damage is controversial. Therefore, such damage was evaluated in hamsters. METHODS:Gastric antral damage was evaluated 4 h after the oro-gastric administration of indomethacin (30 mg/kg). Prior to indomethacin, hamsters were treated with various pharmacological agents: rebamipide, methotrexate or anti-neutrophil serum (ANS). The number of circulating neutrophils was determined from Wright-Giemsa stained blood smears. Myeloperoxidase (MPO) activity was measured as a marker of gastric antral neutrophil infiltration. RESULTS:Indomethacin caused primarily gastric antral damage. By histology, this damage did not penetrate the muscularis mucosa. A significant increase in gastric antral MPO activity was also found in indomethacin-treated hamsters. Rebamipide decreased macroscopic gastric antral damage in a dose-related fashion. Methotrexate treatment reduced the circulating blood neutrophil number by 38-44%, but did not affect gastric damage. ANS treatment resulted in near complete neutropenia, and also in a substantial reduction (84%) in gastric antral MPO activity. However, gastric antral damage was not significantly altered by ANS. CONCLUSIONS:Neutrophils are not directly involved in the pathophysiology of indomethacin-induced damage to the hamster gastric antrum.

journal_name

Aliment Pharmacol Ther

authors

Fitzpatrick LR,Sakurai K,Le T

doi

10.1046/j.1365-2036.1999.00444.x

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

195-202

issue

2

eissn

0269-2813

issn

1365-2036

journal_volume

13

pub_type

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