Validity of 13C-phenylalanine breath test to evaluate functional capacity of hepatocyte in patients with liver cirrhosis and acute hepatitis.

abstract：:The effect of ephedrine, a non-selective adrenoreceptor agonist, and yohimbine, a selective alpha 2-adrenolytic drug, on gastric emptying of a radiolabelled solid meal was examined in groups of 8 (all women) and 15 (4 men and 11 women) obese patients, respectively. Patients were given orally, double-blind in random or...

journal_title：Alimentary pharmacology & therapeutics

authors： Jonderko K,Kucio C

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:CagA protein is encoded by the cagA gene, which is part of the cag pathogenicity island (PAI) in Helicobacter pylori. Insertion sequence (IS) elements are a diverse set of specialized DNA segments that can move to new sites in bacterial genomes. AIM:To determine the role of cagPAI and IS605 in the developme...

journal_title：Alimentary pharmacology & therapeutics

authors： Deguchi R,Igarashi M,Watanabe K,Takagi A

更新日期：2004-07-01 00:00:00

abstract：:The effects of treatment with the Chinese herbal medicine Liu-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms were investigated in 42 patients with chronic idiopathic dyspepsia. By random allocation, 22 patients received oral treatment with 2.5 g TJ-43 three times daily, and 20 patients received ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tatsuta M,Iishi H

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Regulatory requirements for claims of mucosal healing in ulcerative colitis (UC) will require demonstration of both endoscopic and histologic healing. Quantifying these rates is essential for future drug development. AIMS:To meta-analyse endoscopic and histologic placebo response and remission rates in UC r...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Guizzetti L,Panaccione R,Fedorak RN,Pai RK,Parker CE,Nguyen TM,Khanna R,Vande Casteele N,D'Haens G,Sandborn WJ,Feagan BG,Jairath V

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Benign epithelial gastric polyps have been reported to be more common in atrophic body gastritis. The role of Helicobacter pylori infection in the induction of gastric atrophy is well-known. The development of hyperplastic polyps may be in relation to H. pylori infection. AIM:To investigate occurrence of be...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Giulio E,Lahner E,Micheletti A,Milione M,D'Ambra G,Bordi C,Delle Fave G,Annibale B

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The efficacy of interferon-alpha plus ribavirin treatment for patients not responding to interferon monotherapy is not well established. AIM:To assess the efficacy and safety of combination therapy with interferon-alpha 2a/2b plus ribavirin by performing a meta-analysis of randomized clinical trials. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： San Miguel R,Guillén F,Cabasés JM,Buti M

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:In developed countries, hepatitis E is a porcine zoonosis caused by hepatitis E virus (HEV) genotype 3. In developing countries, hepatitis E is mainly caused by genotype 1, and causes increased mortality in patients with pre-existing chronic liver disease (CLD). AIM:To determine the role of HEV in patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： Blasco-Perrin H,Madden RG,Stanley A,Crossan C,Hunter JG,Vine L,Lane K,Devooght-Johnson N,Mclaughlin C,Petrik J,Stableforth B,Hussaini H,Phillips M,Mansuy JM,Forrest E,Izopet J,Blatchford O,Scobie L,Peron JM,Dalton H

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease generally has a benign course; however, patients with non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma. Currently, there is a lack of consensus about optimal NASH treatment. AIM:To assess the efficacy of insulin-sensitizing agents ...

journal_title：Alimentary pharmacology & therapeutics

authors： Rakoski MO,Singal AG,Rogers MA,Conjeevaram H

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:It is unclear whether adherence to prescribing standards has been achieved in inflammatory bowel disease (IBD). AIM:To determine how prescribing of 5-aminosalicylates (5-ASAs), steroids and thiopurines has changed in response to emerging evidence. METHODS:We examined trends in oral and topical therapies in...

journal_title：Alimentary pharmacology & therapeutics

authors： Chhaya V,Saxena S,Cecil E,Subramanian V,Curcin V,Majeed A,Pollok RC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Pancreatic enzyme replacement therapy (PERT) is necessary to prevent severe maldigestion and unwanted weight loss associated with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP) or pancreatic surgery (PS). AIM:To assess the long-term safety and efficacy of pancrelipase (pancreatin) ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gubergrits N,Malecka-Panas E,Lehman GA,Vasileva G,Shen Y,Sander-Struckmeier S,Caras S,Whitcomb DC

更新日期：2011-05-01 00:00:00

abstract：:The knowledge of the natural history of patients with hepatocellular carcinoma is important to estimate the prognosis at diagnosis and indicate the best therapy. Prognosis is related to tumour stage at diagnosis, degree of liver function impairment induced either by the tumour itself or by the underlying cirrhosis, ge...

journal_title：Alimentary pharmacology & therapeutics

authors： Varela M,Sala M,Llovet JM,Bruix J

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Predicting factors for the outcome of conventional Helicobacter pylori triple therapy have been identified. Of these, the presence of the CagA gene is a strong predictor of successful treatment. Our preliminary data show that this factor becomes irrelevant when sequential therapy is used. AIM:To identify pr...

journal_title：Alimentary pharmacology & therapeutics

authors： De Francesco V,Zullo A,Margiotta M,Marangi S,Burattini O,Berloco P,Russo F,Barone M,Di Leo A,Minenna MF,Stoppino V,Morini S,Panella C,Francavilla A,Ierardi E

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:Intra-oesophageal impedance monitoring can be used to assess the clearance of a swallowed bolus (oesophageal transit) and to detect gastro-oesophageal reflux independent of its acidity. AIM:To discuss the clinical application of the impedance technique for the assessment of bolus transit and gastro-oesophag...

journal_title：Alimentary pharmacology & therapeutics

authors： Conchillo JM,Smout AJ

更新日期：2009-01-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GERD), manifesting with symptoms including heartburn and regurgitation, affects people during both daytime and nocturnal hours. Night-time GERD has been reported to have a greater impact on a patient's life than daytime GERD due to prolonged oesophageal acid exposure time per reflux ...

journal_title：Alimentary pharmacology & therapeutics

authors： Shaker R,Brunton S,Elfant A,Golopol L,Ruoff G,Stanghellini V

更新日期：2004-12-01 00:00:00

abstract：:Erythromycin is a prokinetic agent for the lower oesophageal sphincter, the stomach, the gallbladder and the small bowel, acting directly on motilin receptors. Its effect on pressure activity of the human colon has not been investigated. Eight healthy volunteers were studied on 2 occasions and given intravenous or ora...

journal_title：Alimentary pharmacology & therapeutics

authors： Jameson JS,Rogers J,Misiewicz JJ,Raimundo AH,Henry MM

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. AIM:To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tuleu C,Basit AW,Waddington WA,Ell PJ,Newton JM

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Low bone mineral density (BMD) has been reported in both paediatric and adult patients with non-alcoholic fatty liver disease (NAFLD). The mechanisms behind the reduced BMD in NAFLD are still not completely understood. AIM:To provide a critical overview of the pathophysiological pathways linking NAFLD, redu...

journal_title：Alimentary pharmacology & therapeutics

authors： Yilmaz Y

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors effectively suppress intragastric acid. Nocturnal acid breakthrough occurs on any dosing regimen of oral proton pump inhibitors. Histamine(2)-receptor antagonists (H(2)RA) suppress intragastric acidity independently of meals and help to control nocturnal acid breakthrough. Because prot...

journal_title：Alimentary pharmacology & therapeutics

authors： Tutuian R,Katz PO,Ahmed F,Korn S,Castell DO

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Diagnosis of inflammatory bowel disease (IBD) is based on clinical presentation, colonoscopy and histology. Differentiation of Crohn's disease (CD) and ulcerative colitis (UC) can be difficult in some patients. Endoscopic ultrasound (EUS) provides high resolution images of the gastrointestinal wall (GI) and ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ellrichmann M,Wietzke-Braun P,Dhar S,Nikolaus S,Arlt A,Bethge J,Kuehbacher T,Wintermeyer L,Balschun K,Klapper W,Schreiber S,Fritscher-Ravens A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The effect of anti-viral treatment on downstream costs for hepatitis C virus (HCV)-infected patients is unknown. AIM:To evaluate follow-up costs in patients with chronic HCV, stratified by liver disease severity. METHODS:Using a US private insurance database, mean all-cause per-patient-per-month (PPPM) US ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gordon SC,Hamzeh FM,Pockros PJ,Hoop RS,Buikema AR,Korner EJ,Terrault NA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Infection is the most common cause of mortality in end-stage liver disease (ESLD). The impact of obesity on infection risk in ESLD is not established. AIM:To characterise the impact of obesity on infection risk in ESLD. METHODS:We evaluated the association between infection and obesity in patients with ESL...

journal_title：Alimentary pharmacology & therapeutics

authors： Sundaram V,Kaung A,Rajaram A,Lu SC,Tran TT,Nissen NN,Klein AS,Jalan R,Charlton MR,Jeon CY

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Occult biliary stones escape detection on conventional investigations, and clinico-biochemical systems proposed for predicting biliary pancreatitis has low predictive values. AIM:To evaluate the accuracy of clinico-biochemical parameters for prediction of biliary pancreatitis in patients undergoing endoscop...

journal_title：Alimentary pharmacology & therapeutics

authors： Liu CL,Fan ST,Lo CM,Tso WK,Wong Y,Poon RT,Lam CM,Wong BC,Wong J

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Epidemiological studies of microscopic colitis have shown varying but increasing incidence rates. AIM:To assess the incidence of microscopic colitis in Sweden. METHODS:Nationwide cohort study performed in 1995-2015 based on biopsy reports. Age-specific and age-standardised incidence rates were calculated. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Bergman D,Clements MS,Khalili H,Agréus L,Hultcrantz R,Ludvigsson JF

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:While current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is often times attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Szeinbach SL,Baran RW,Dietz B,Gazzouola Rocca L,Littlefield D,Yawn BP

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Oral nonsteroidal anti-inflammatory drugs (NSAIDs) cause acute gastric mucosal injury but the relative importance of systemic and topical effect of NSAIDs to overall gastric damage remains uncertain. METHODS:Twenty-four healthy volunteers were allocated either oral or rectal naproxen 500 mg b.d. and gastr...

journal_title：Alimentary pharmacology & therapeutics

authors： Lipscomb GR,Rees WD

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Treatment options for non-alcoholic steatohepatitis (NASH) are limited. Weight loss remains the most recommended therapy. Orlistat is an effective adjunct to dietary weight loss therapy. AIM:To evaluate the efficacy of orlistat, given for 6 months to patients with obesity and biopsy confirmed NASH. METHODS...

journal_title：Alimentary pharmacology & therapeutics

authors： Harrison SA,Fincke C,Helinski D,Torgerson S,Hayashi P

更新日期：2004-09-15 00:00:00

abstract：BACKGROUND:The low Fermentable Oligo-, Di- Monosaccharides, and Polyoles (FODMAP) diet is a new treatment option for irritable bowel syndrome (IBS). Experts refer to the diet as supported by high level of evidence, but an evaluation of the quality of trials is lacking. AIM:To provide a systematic review of the quality...

journal_title：Alimentary pharmacology & therapeutics

authors： Krogsgaard LR,Lyngesen M,Bytzer P

更新日期：2017-06-01 00:00:00

abstract：:Although up to 50% of patients diagnosed with nonulcer dyspepsia (NUD) have Helicobacter pylori infection and underlying chronic gastritis, it remains controversial whether any causal relationship exists. The results of worldwide epidemiological studies have been unconvincing. No clear-cut link has been documented bet...

journal_title：Alimentary pharmacology & therapeutics

authors： Talley NJ,Quan C

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM:To investigate trends ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lophaven SN,Lynge E,Burisch J

更新日期：2017-04-01 00:00:00

abstract：AIM:To appraise the tolerance and efficacy of an induction of tolerance protocol to infliximab permitting the re-administration of the drug to patients with Crohn's disease having had infusion reactions requiring suspension of treatment. METHODS:Fourteen patients were included in the induction of tolerance protocol. E...

journal_title：Alimentary pharmacology & therapeutics

authors： Duburque C,Lelong J,Iacob R,Seddik M,Desreumaux P,Fournier C,Wallaert B,Cortot A,Colombel JF

更新日期：2006-09-01 00:00:00